HR-slowing agents

systematic review meta-analysis network meta-analysis

Select heart failurestable angina All type of patientuncoded clinical condition ***patients with left ventricular dysfunction       ivabradineivabradine + beta-blockersivabradine + calcium blocker diltiazemverapamilatenololivabradinemetoprolol vs placebo or controlvs beta-blockersvs calcium blockers      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (1)Cardiovascular death or hospital admission for CHF (1)heart failure death (1)hospitalisation for heart failure (1)Cardiovascular death (1)hospitalisation for cardiovascular causes (1)CV death, MI hospitalization for HF (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	Cardiovascular death or hospital admission for CHF
heart failure
ivabradine
SHIFT, 2010	ivabradine	placebo			Low risk of bias	suggesting
BEAUTIFUL, 2008    NCT	ivabradine 15mg	placebo			Low risk of bias	negative
stable angina
ivabradine
Borer (CL2-009) 10mg, 2003	ivabradine 10mg	placebo			Low risk of bias	-
BEAUTIFUL, 2008    NCT	ivabradine 15mg	placebo			Low risk of bias	negative
Borer (CL2-009) 20mg, 2003	ivabradine 20mg	placebo			Low risk of bias	-
SIGNIFY, 2014	ivabradine 20mg	placebo			Low risk of bias	negative
Borer (CL2-009) 5mg, 2003	ivabradine 5mg	placebo			Low risk of bias	-
BEAUTIFUL (angina subgroup)	ivabradine 15mg	placebo (on top standard treatment)			Low risk of bias	suggesting
CL3-018 10mg	ivabradine 10mg	placebo on top of amlodipine				-
CL3-018 15mg	ivabradine 15mg	placebo on top of amlodipine				-
ASSOCIATE (Tardif), 2009    NCT	ivabradine 15mg	placebo on top of atenolol			Low risk of bias	-
CL3-023 (15mg)	ivabradine	amlodipine			Low risk of bias	-
CL3-023 (20mg)	ivabradine	amlodipine			Low risk of bias	-
Ruzyllo (CL3-023) 15mg, 2007	ivabradine 15mg	amlodipine			Low risk of bias	-
Ruzyllo (CL3-023) 20mg, 2007	ivabradine 20mg	amlodipine			Low risk of bias	-
INITIATIVE (CL3-017, Tardif) 15mg, 2005	ivabradine 15mg	atenolol			Low risk of bias	-
INITIATIVE (CL3-017, Tardif) 20mg, 2005	ivabradine 20mg	atenolol			Low risk of bias	-