phosphodiesterase III inhibitors

systematic review meta-analysis network meta-analysis

Select heart failure All type of patient       Phosphodiesterase III inhibitors amrinoneEnoximoneFlosequinanibopamineMilrinonevesnarinone vs placebo or control      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	All cause death (23)Sudden death (12)Worsening heart failure (11)Arrhythmia (10)cardiac death (9)myocardial infarction (fatal and non fatal) (8)Vertigo (7)Transplantation (4)Death from any cause or hospitalization for heart failure (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	All cause death	Sudden death
heart failure
amrinone
AMTG, 1985	Amrinone	placebo			Low risk of bias	negative
Enoximone
WESG, 1991	Enoximone	placebo			Low risk of bias	negative
EMTG, 1990	Enoximone	placebo			Low risk of bias	negative
ESG, 2000	Enoximone	placebo			Low risk of bias	negative
Lardoux, 1987	Enoximone	placebo			Low risk of bias	negative
ESSENTIAL (I and II), 2009    NCT	enoximone	placebo			Low risk of bias	negative
Cowley, 1994	Enoximone	placebo			Low risk of bias	negative
EMOTE, 2007	enoximone	placebo			Low risk of bias	-
Flosequinan
Cowley, 1993	Flosequinan	placebo			Low risk of bias	negative
FACET, 1993	Flosequinan	placebo			Low risk of bias	negative
REFLECT, 1993	Flosequinan	placebo			Low risk of bias	negative
REFLECT II, 1991	Flosequinan	placebo			Low risk of bias	negative
ibopamine
PRIME II, 1997	ibopamine	placebo			Low risk of bias	negative
Milrinone
PROMISE, 1991	Milrinone	placebo			Low risk of bias	negative
MMTG, 1989	Milrinone	placebo			Low risk of bias	negative
vesnarinone
OPC-8212 MRG, 1990	Vesnarinone	placebo			Low risk of bias	negative
VEST, 1998	Vesnarinone	placebo			Low risk of bias	negative
VSG, 1993	Vesnarinone	placebo			Low risk of bias	suggesting