insulin therapy

systematic review meta-analysis network meta-analysis

Select diabetes type 2 uncoded clinical condition ***       aAAAbasal + bolusbasal insulininsulin therapylixisenatideonce daily premixed insulin analoguethrice daily premixed insulin analoguetwice-daily premixed insulin analogue glarginelixisenatide vs basal insulinvs placebo or control      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	HbA1c <7% (4)HbA1c < 6.5% (2)noctural hypoglycemia (2)All cause death (2)Cardiovascular death (2)myocardial infarction (fatal and non fatal) (2)Sudden death (2)vision loss (2)Amputations (2)change in HbA1c (%) (1)severe hypoglycemia (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	HbA1c <7%	HbA1c < 6.5%
diabetes type 2
glargine
Rosenstock	glargine					suggesting
Eliaschewitz	glargine					suggesting
Massi	glargine					suggesting
Yki-Yarvinen	glargine					negative
Fonseca	glargine					negative
Pan	glargine					-
Philis-Tsimikas	glargine					suggesting
Wang	glargine					suggesting
Yki-Yarvinen	glargine					suggesting
Yokoyama	glargine					negative
Fritche	morning insulin glargine	bedtime insulin glargine				suggesting
Herman, 2005	lispro +glargine	continuous infusion				-
Owens, 2011	insulin glulisine + glargine	glargine once daily			Risk of bias	negative
OPAL, 2008	glulisine + glargine	glulisine + glargine				-
Riddle POC 4002 Glargine, 2003	glargine	NPH			Risk of bias	-
HOE 901/3002, 2000	glargine	NPH				-
Riddle	glargine	NPH + SU				negative
lixisenatide
GETGOAL-L    NCT	lixisenatide	glargine once daily			Low risk of bias	-