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vasopeptidase inhibitor

treatment

comparator

All cause death

hospitalisation for heart failure

cardiovascular events

Death from any cause or hospitalization for heart failure

Omapatrilat

heart failure, in all type of patients

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Endpoint	TE [95% CI]	p val	I2	n	k	trials
All cause death	no data
hospitalisation for heart failure	no data
cardiovascular events	no data
Death from any cause or hospitalization for heart failure	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Trial	Studied treatment	Control	Patients
OVERTURE, 2002	omapatrilat 40 mg once dailyitm	enalapril 10 mg twice daily	patients with NYHA II-IV heart failure

Omapatrilat

heart failure, in all type of patients

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Endpoint	TE [95% CI]	p val	I2	n	k	trials
All cause death	0.69 [0.26 1.83]	p=1.00	0	573	1	IMPRESS,
hospitalisation for heart failure	0.44 [0.19 1.02]	p=1.00	0	573	1	IMPRESS,
cardiovascular events	no data
Death from any cause or hospitalization for heart failure	0.52 [0.27 1.00]	p=0.04	0	573	1	IMPRESS,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Trial	Studied treatment	Control	Patients
IMPRESS, 2000	omapatrilat target dose 40 mg daily	lisinopril target dose 20mg daily	patients with NTHA II-IV congestive heart failure, LEVF <=40%, and receiving ACE inhibitor

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