| treatment |
|
comparator |
All cause death | Major bleeding | Deep vein thrombosis | Venous thromboembolism | pulmonary embolism (symptomatic and asymptomatic) |
|
|
| UFH | thrombosis prevention, in all type of patients | vs control | - | - | NS | - | - | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
|---|
| All cause death | no data | | Major bleeding | no data | | Deep vein thrombosis | 0.40 [0.03 4.58] | p=1.00 | 0 | 90 | 1 | Killewich, | | Venous thromboembolism | no data | | pulmonary embolism (symptomatic and asymptomatic) | no data |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients | Trial | Studied treatment | Control | Patients |
|---|
| Killewich, 1997 | low-dose heparin sodium therapy (5000 U every 12 hours) and calf-length intermittent mechanical compression devices | no prophylaxis | patients undergoing aortic reconstruction for aneurysmal or occlusive disease |
|
| UFH | thrombosis prevention, in all type of patients | vs UFH | - | - | by 47% | - | by 58% | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
|---|
| All cause death | no data | | Major bleeding | no data | | Deep vein thrombosis | 0.53 [0.33 0.84] | p=0.04 | 0 | 766 | 5 | Wille-Jorgensen, Wille-Jorgensen, *Rasmussen (adj), Siragusa (H), Torngren, | | Venous thromboembolism | no data | | pulmonary embolism (symptomatic and asymptomatic) | 0.42 [0.25 0.70] | p=0.04 | 0 | 2699 | 3 | Wille-Jorgensen, Siragusa (H), Ramos, |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients | Trial | Studied treatment | Control | Patients |
|---|
| Wille-Jorgensen, 1991 | low dose heparin and graded compression stockings | low dose heparin | patients undergoing Abdominal surgery | | Wille-Jorgensen, 1985 | low-dose heparin treatment with graded compression stockings | low-dose heparin treatment (5000 units twice daily subcutaneously) | patients undergoing Abdominal surgery | | *Rasmussen (adj), 1988 | subcutaneous heparin and graduated compression stockings to the knee (TED stockings), | subcutaneous heparin | patients (age more than 40 yrs) admitted for major abdominal surgery | | Siragusa (H), 1994 | | | | | Ramos, 1996 | prophylactic regimen of Pneumatic compression stocking and subcutaneous heparin | with 5,000 U of subcutaneous heparin every 12 h | cardiac surgery | | Torngren, 1980 | | | |
|
| UFH | thrombosis prevention, in general non orthopaedic surgery | vs UFH | - | - | NS | - | NS | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
|---|
| All cause death | no data | | Major bleeding | no data | | Deep vein thrombosis | 0.57 [0.32 1.00] | p=1.00 | 0 | 516 | 3 | Wille-Jorgensen, Wille-Jorgensen, *Rasmussen (adj), | | Venous thromboembolism | no data | | pulmonary embolism (symptomatic and asymptomatic) | 0.30 [0.01 7.41] | p=1.00 | 0 | 178 | 1 | Wille-Jorgensen, |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients | Trial | Studied treatment | Control | Patients |
|---|
| Wille-Jorgensen, 1991 | low dose heparin and graded compression stockings | low dose heparin | patients undergoing Abdominal surgery | | Wille-Jorgensen, 1985 | low-dose heparin treatment with graded compression stockings | low-dose heparin treatment (5000 units twice daily subcutaneously) | patients undergoing Abdominal surgery | | *Rasmussen (adj), 1988 | subcutaneous heparin and graduated compression stockings to the knee (TED stockings), | subcutaneous heparin | patients (age more than 40 yrs) admitted for major abdominal surgery |
|
| Aspirin | thrombosis prevention, in all type of patients | vs aspirin | - | - | NS | - | - | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
|---|
| All cause death | no data | | Major bleeding | no data | | Deep vein thrombosis | 0.68 [0.27 1.74] | p=1.00 | 0 | 258 | 2 | Lieberman (A), Hull (+asp), | | Venous thromboembolism | no data | | pulmonary embolism (symptomatic and asymptomatic) | no data |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients | Trial | Studied treatment | Control | Patients |
|---|
| Lieberman (A), 1994 | hypotensive epidural anesthesia, external pneumatic-compression boots, and aspirin | hypotensive epidural anesthesia and aspirin | primary unilateral or bilateral total hip arthroplasty with use of hypotensive epidural anesthesia | | Hull (+asp), 1979 | | | patients undergoing elective knee surgery | | Hull 2 (+asp), 1979 | | | patients undergoing elective knee surgery |
|
| Aspirin | thrombosis prevention, in all type of patients | vs LMWH | - | - | - | - | - | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
|---|
| All cause death | no data | | Major bleeding | no data | | Deep vein thrombosis | no data | | Venous thromboembolism | no data | | pulmonary embolism (symptomatic and asymptomatic) | no data |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients | Trial | Studied treatment | Control | Patients |
|---|
| Gelfer, 2006 | continuous enhanced circulation therapy (CECT) combined with low-dose aspirin | enoxaparin 40 mg daily | patients who underwent total hip or knee arthroplasty |
|
