Albiglutide | diabetes type 2, in patients inadequately controlled on metformin | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | 1.65 [0.03 85.07] | p=1.00 | 0 | 82 | 1 | Rosenstock (30 mg weekly), |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock (30 mg weekly), 2009 | albiglutide
30mg weekly | placebo | patients with type 2 diabetes inadequately controlled with diet and exercise or
metformin monotherapy |
| |
Albiglutide | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | 1.65 [0.03 85.07] | p=1.00 | 0 | 82 | 1 | Rosenstock (30 mg weekly), |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock (30 mg weekly), 2009 | albiglutide
30mg weekly | placebo | patients with type 2 diabetes inadequately controlled with diet and exercise or
metformin monotherapy |
| |
Dapagliflozin | diabetes type 2, in patients inadequately controlled on metformin | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Bailey (MB102014), 2010 | dapagliflozin (2¡¤5 mg, n=137; 5 mg, n=137; or 10 mg, n=135) | placebo | adults with type 2 diabetes who were receiving daily metformin (¡Ý1500 mg per day) and had inadequate glycaemic control |
| |
Dapagliflozin | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Bailey (MB102014), 2010 | dapagliflozin (2¡¤5 mg, n=137; 5 mg, n=137; or 10 mg, n=135) | placebo | adults with type 2 diabetes who were receiving daily metformin (¡Ý1500 mg per day) and had inadequate glycaemic control |
| |
Pioglitazone | diabetes type 2, in patients inadequately controlled with insulin | vs placebo (add on insulin) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
all cause death, MI, stroke | 0.71 [0.07 6.86] | p=1.00 | 0 | 788 | 2 | PNFP-014, OPI-502, | cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | 0.71 [0.07 6.86] | p=1.00 | 0 | 788 | 2 | PNFP-014, OPI-502, | stroke (fatal and non fatal) | 0.71 [0.04 11.38] | p=1.00 | 0 | 788 | 2 | PNFP-014, OPI-502, | Heart failure | 2.22 [0.21 23.67] | p=1.00 | 0 | 788 | 2 | PNFP-014, OPI-502, | All cause death | 0.71 [0.04 11.38] | p=1.00 | 0 | 788 | 2 | PNFP-014, OPI-502, |
Trial | Studied treatment | Control | Patients |
---|
PNFP-014, | Pioglitazone insulin | Placebo + insulin | patients with type 2 diabetes | OPI-502, | Pioglitazone + insulin | Placebo + insulin | Insulin-dependent DM-2 |
| |
Alogliptin | diabetes type 2, in patients inadequately controlled on metformin | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Nauck, 2009 | alogliptin 12.5 and 25 mg once daily | placebo | patients whose HbA(1c) levels were inadequately controlled on metformin alone |
| |
Alogliptin | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Nauck, 2009 | alogliptin 12.5 and 25 mg once daily | placebo | patients whose HbA(1c) levels were inadequately controlled on metformin alone |
| |
Linagliptin | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on SU) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Lewin, 2010 | linagliptin 5 mg
| placebo (add-on to sulphonylurea)
| patients with type 2 diabetes and insufficient glycaemic control
|
| |
Linagliptin | | vs glimepiride (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
Gallwitz, 2012 | linagliptin (5 mg once daily) add-on therapy to preferably > 1500 mg metformin | glimepiride (1—4 mg) orally once daily add-on therapy to preferably > 1500 mg metformin | type 2 diabetes mellitus with insufficient glycaemic control with metformin |
| |
Linagliptin | diabetes type 2, in patients insufficiently controlled on SU | vs placebo (add on SU) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Lewin, 2010 | linagliptin 5 mg
| placebo (add-on to sulphonylurea)
| patients with type 2 diabetes and insufficient glycaemic control
|
| |
Linagliptin | diabetes type 2, in Patients inadequately controlled on MET+SU therapy | vs Metformin + sulfonylurea | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Owens, 0 | linagliptin
| combination of metformin and an SU
| type 2 diabetes mellitus with insufficient glycaemic control with metformin in combination with a sulphonylurea
|
| |
Linagliptin | diabetes type 2, in patients with insufficient glycaemic control with bitherapy | vs Metformin + sulfonylurea | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Owens, 0 | linagliptin
| combination of metformin and an SU
| type 2 diabetes mellitus with insufficient glycaemic control with metformin in combination with a sulphonylurea
|
| |
Linagliptin | diabetes type 2, in drug naïve patients | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Del Prato, 0 | Linagliptin monotherapy
| placebo
| Type 2 Diabetic Patients With Insufficient Glycemic Control
|
| |
Linagliptin | diabetes type 2, in patients inadequately controlled on metformin | vs glimepiride (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
Gallwitz, 2012 | linagliptin (5 mg once daily) add-on therapy to preferably > 1500 mg metformin | glimepiride (1—4 mg) orally once daily add-on therapy to preferably > 1500 mg metformin | type 2 diabetes mellitus with insufficient glycaemic control with metformin |
| |
Saxagliptin | diabetes type 2, in patients inadequately controlled on metformin | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
DeFronzo, 2009 | saxagliptin (2.5, 5, or 10 mg once daily) | placebo | Patients With Inadequately Controlled
Type 2 Diabetes With Metformin Alone | CV181-080, | 2.5 mg Saxagliptin, Twice Daily | placebo | Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin IR Alone |
| |
Saxagliptin | | vs sitagliptin (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
saxagliptin vs sitagliptin, | saxagliptin 5 mg once daily add on metformin | sitagliptin 100 mg onece daily add on metformin | adults with type 2 diabetes who did not attain adequate glycemic control on metformin therapy alone |
| |
Saxagliptin | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
DeFronzo, 2009 | saxagliptin (2.5, 5, or 10 mg once daily) | placebo | Patients With Inadequately Controlled
Type 2 Diabetes With Metformin Alone | Jadzinsky, 2009 | saxagliptin | placebo | treatment-naïve patients with type 2 diabetes (T2D) and inadequate glycaemic control | CV181-066, | Saxagliptin | placebo | Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control With Diet And Exercise And A Stable Dose Of Metformin ¡Ý1500 mg/Day | CV181-080, | 2.5 mg Saxagliptin, Twice Daily | placebo | Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin IR Alone |
| |
Saxagliptin | | vs placebo (add on TZD) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Hollander, | saxagliptin (2.5 or 5 mg) | placebo | patients with type 2 diabetes and inadequate control on thiazolidinedione alone |
| |
Saxagliptin | | vs sitagliptin (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
saxagliptin vs sitagliptin, | saxagliptin 5 mg once daily add on metformin | sitagliptin 100 mg onece daily add on metformin | adults with type 2 diabetes who did not attain adequate glycemic control on metformin therapy alone |
| |
Saxagliptin | diabetes type 2, in in patients inadequately controlled on standard therapy | vs placebo (add on current treatment) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
saxgliptin, renal study, | saxagliptin | placebo added to patients’ current diabetes treatment | patients with moderate to severe renal impairment or end-stage renal disease |
| |
Saxagliptin | diabetes type 2, in drug naïve patients | vs placebo (monotherapy) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock, 2008 | saxagliptin 2.5, 5, 10, 20 or 40 mg once daily | placebo | drug-naive patients with T2DM and inadequate glycaemic control | CV181-011, | oral saxagliptin 2.5, 5, or 10 mg once daily | placebo | | CV181-038, | Saxagliptin monotherapy | placebo | type 2 diabetic subjects who are not controlled with diet and exercise | CV181-041, | Saxagliptin | placebo | Subjects With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise |
| |
Saxagliptin | diabetes type 2, in patients inadequately controlled with insulin | vs placebo (add on insulin) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
CV181-057, | Saxagliptin, 5 mg | placebo (on top insulin) | Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control on Insulin Alone or on Insulin in Combination With Metformin |
| |
Saxagliptin | diabetes type 2, in patients inadequately controlled on TZD | vs placebo (add on TZD) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Hollander, | saxagliptin (2.5 or 5 mg) | placebo | patients with type 2 diabetes and inadequate control on thiazolidinedione alone |
| |
Sitagliptin | diabetes type 2, in patients inadequately controlled on metformin | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 1.02 [0.61 1.68] | p=1.00 | 0 | 2058 | 3 | Charbonnel, Nauck, Scott** (sit vs pbo on top met), |
Trial | Studied treatment | Control | Patients |
---|
Charbonnel, 2006 | sitagliptin 100 mg daily (add-on to metformin therapy)j | placebo (add-on tometformin therapy); | | Nauck, 2007 | sitagliptin 100 mg daily (add-on to metformin therapy)j | placebo (add-on to metformin therapy); | | Scott** (sit vs pbo on top met), 2007 | sitagliptin 100 mg daily (add-on to metformin therapy)j | placebo (add-on to metformin therapy). | patients with type 2 diabetes who were inadequately on mET monotherapy |
| |
Sitagliptin | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 1.02 [0.61 1.68] | p=1.00 | 0 | 2058 | 3 | Charbonnel, Nauck, Scott** (sit vs pbo on top met), |
Trial | Studied treatment | Control | Patients |
---|
Charbonnel, 2006 | sitagliptin 100 mg daily (add-on to metformin therapy)j | placebo (add-on tometformin therapy); | | Nauck, 2007 | sitagliptin 100 mg daily (add-on to metformin therapy)j | placebo (add-on to metformin therapy); | | Scott** (sit vs pbo on top met), 2007 | sitagliptin 100 mg daily (add-on to metformin therapy)j | placebo (add-on to metformin therapy). | patients with type 2 diabetes who were inadequately on mET monotherapy |
| |
Sitagliptin | | vs placebo (on top PIO) | Adverse events leading to treatment discontinuation by 459% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 5.59 [1.22 25.62] | p=0.04 | 0 | 353 | 1 | Rosenstock (sit on top pio vs pbo), |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock (sit on top pio vs pbo), 2006 | sitagliptin 100 mg daily (add-on to pioglitazone therapy)sl˜ðõØ | placebo (add-on to pioglitazone therapy); | |
| |
Sitagliptin | diabetes type 2, in patients with insufficient glycaemic control with bitherapy | vs placebo (on-top glimepiride+/- metformine) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 2.74 [0.28 26.77] | p=1.00 | 0 | 222 | 1 | Hermansen, |
Trial | Studied treatment | Control | Patients |
---|
Hermansen, 2007 | sitagliptin 100 mg daily (add-on to ongoing stable doses of glimepiride, alone or in combination with metformin)ocumen | placebo (add-on to ongoing stable doses of glimepiride, alone or in combination with metformin); | |
| |
Vildagliptin | diabetes type 2, in patients inadequately controlled on metformin | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 1.63 [0.50 5.36] | p=1.00 | 0 | 471 | 2 | Ahren, Bosi, |
Trial | Studied treatment | Control | Patients |
---|
Ahren, 2004 | vildagliptin 50 mg daily (add-on to metformin therapy)j | placebo (add-on to metformin therapy)mag | patients with type 2 diabetes | Bosi, 2007 | vildagliptin (50 or) 100 mg daily (add-on to metformin therapy)m | placebo (add-on to metformin therapy)mag | patients with type 2 diabetes inadequately controlled with metformin | Goodman, 2009 | ildagliptin 100 mg given in the morning, vildagliptin 100 mg given in the evening | placebo | patients inadequately controlled with metformin |
| |
Vildagliptin | | vs Sulfonylurea (add on to MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Ferrannini, 2009 | vildagliptin 50 mg twice daily | glimepiride titrated up to 6 mg/day | Patients inadequately controlled on metformin monotherapy (HbA(1c) 6.5-8.5%) |
| |
Vildagliptin | | vs pioglitazone (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 0.95 [0.37 2.44] | p=1.00 | 0 | 576 | 1 | Bolli, |
Trial | Studied treatment | Control | Patients |
---|
Bolli, 2008 | vildagliptin 100 mg daily (add-on to metformin therapy) | pioglitazone 30 mg daily (add-on to metformin therapy)j | patients with type 2 diabetes inadequately controlled with metformin monotherapy |
| |
Vildagliptin | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on insulin) | Adverse events leading to treatment discontinuation by 850% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 9.50 [1.19 75.97] | p=0.04 | 0 | 296 | 1 | Fonseca, |
Trial | Studied treatment | Control | Patients |
---|
Fonseca, 2007 | vildagliptin 100 mg daily (add-on to insulin therapy)y) | placebo (add-on to insulin therapy)y)mag | type 2 diabetes that was inadequately controlled by insulin |
| |
Vildagliptin | | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 1.63 [0.50 5.36] | p=1.00 | 0 | 471 | 2 | Ahren, Bosi, |
Trial | Studied treatment | Control | Patients |
---|
Ahren, 2004 | vildagliptin 50 mg daily (add-on to metformin therapy)j | placebo (add-on to metformin therapy)mag | patients with type 2 diabetes | Bosi, 2007 | vildagliptin (50 or) 100 mg daily (add-on to metformin therapy)m | placebo (add-on to metformin therapy)mag | patients with type 2 diabetes inadequately controlled with metformin | Goodman, 2009 | ildagliptin 100 mg given in the morning, vildagliptin 100 mg given in the evening | placebo | patients inadequately controlled with metformin |
| |
Vildagliptin | | vs placebo (on top pioglitazone) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 1.25 [0.33 4.74] | p=1.00 | 0 | 316 | 1 | Garber, |
Trial | Studied treatment | Control | Patients |
---|
Garber, 2007 | vildagliptin 50 or 100 mg daily (add-on to pioglitazone therapy) | placebo (add-on to pioglitazone therapy) | |
| |
Vildagliptin | | vs Sulfonylurea (add on to MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Ferrannini, 2009 | vildagliptin 50 mg twice daily | glimepiride titrated up to 6 mg/day | Patients inadequately controlled on metformin monotherapy (HbA(1c) 6.5-8.5%) |
| |
Vildagliptin | | vs pioglitazone (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 0.95 [0.37 2.44] | p=1.00 | 0 | 576 | 1 | Bolli, |
Trial | Studied treatment | Control | Patients |
---|
Bolli, 2008 | vildagliptin 100 mg daily (add-on to metformin therapy) | pioglitazone 30 mg daily (add-on to metformin therapy)j | patients with type 2 diabetes inadequately controlled with metformin monotherapy |
| |
Vildagliptin | | vs placebo (add on TZD) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 0.47 [0.14 1.55] | p=1.00 | 0 | 314 | 1 | Rosenstock** (vilda + pio vs pio), |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock** (vilda + pio vs pio), 2007 | vildagliptin 50 mg or 100 mg daily plus 15 mg or 30 mg pioglitazone dailyi | pioglitazone 30 mg daily | drug-naive patients with type 2 diabetes |
| |
Vildagliptin | diabetes type 2, in patients inadequately controlled with insulin | vs placebo (add on insulin) | Adverse events leading to treatment discontinuation by 850% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 9.50 [1.19 75.97] | p=0.04 | 0 | 296 | 1 | Fonseca, |
Trial | Studied treatment | Control | Patients |
---|
Fonseca, 2007 | vildagliptin 100 mg daily (add-on to insulin therapy)y) | placebo (add-on to insulin therapy)y)mag | type 2 diabetes that was inadequately controlled by insulin |
| |
Vildagliptin | diabetes type 2, in patients inadequately controlled on TZD | vs placebo (on top pioglitazone) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 1.25 [0.33 4.74] | p=1.00 | 0 | 316 | 1 | Garber, |
Trial | Studied treatment | Control | Patients |
---|
Garber, 2007 | vildagliptin 50 or 100 mg daily (add-on to pioglitazone therapy) | placebo (add-on to pioglitazone therapy) | |
| |
Vildagliptin | | vs placebo (add on TZD) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 0.47 [0.14 1.55] | p=1.00 | 0 | 314 | 1 | Rosenstock** (vilda + pio vs pio), |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock** (vilda + pio vs pio), 2007 | vildagliptin 50 mg or 100 mg daily plus 15 mg or 30 mg pioglitazone dailyi | pioglitazone 30 mg daily | drug-naive patients with type 2 diabetes |
| |
Exenatide | diabetes type 2, in patients with insufficient glycaemic control with bitherapy | vs weekly exenatide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
phase 2 exenatide once monthly, | exenatide once monthly at a low, medium or high dose, each administered once every four weeks, for a total of 20 weeks | exenatide 2mg once weekly | adults with type 2 diabetes who were not achieving adequate glucose control using diet and exercise alone or with a stable regimen of metformin, pioglitazone, or both |
| |
Exenatide | | vs placebo (add on MER+/-SU) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Fineman, 2003 | exenatide 3 regimen (0.08 micro g/kg) for 28 days | placebo | patients with tyep 2 diabetes treated with diet and a sulfonylurea and/or metformin |
| |
Exenatide | | vs placebo (add on MET+/-SU) | all hypoglycemia by 292% adverse event treatment-emergent adverse events (TEAEs) by 58% adverse event A CHANGER by 2825% adverse event vomiting by 7336% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.99 [0.02 50.18] | p=1.00 | 0 | 466 | 1 | Gao, | all hypoglycemia | 3.92 [2.32 6.61] | p=0.04 | 0 | 466 | 1 | Gao, | severe hypoglycemia | 1.98 [0.18 22.02] | p=1.00 | 0 | 466 | 1 | Gao, | treatment-emergent adverse events (TEAEs) | 1.58 [1.09 2.30] | p=0.04 | 0 | 466 | 1 | Gao, | serious adverse events | no data | severe adverse events | no data | A CHANGER | 29.25 [7.05 121.35] | p=0.04 | 0 | 466 | 1 | Gao, | vomiting | 74.36 [4.54 1218.83] | p=0.04 | 0 | 466 | 1 | Gao, | diarrhoea | 1.49 [0.52 4.25] | p=1.00 | 0 | 466 | 1 | Gao, | All cause death | 0.99 [0.02 50.18] | p=1.00 | 0 | 466 | 1 | Gao, | cardiovascular events | 0.20 [0.01 4.15] | p=1.00 | 0 | 466 | 1 | Gao, |
Trial | Studied treatment | Control | Patients |
---|
Gao, 2009 | exenatide 5 mg then 10 mg twice-daily for 4 and 12 weeks | placebo
| Asian desccent with type 2 diabetes and inadequate glycemic control taking
metformin alone or Met and sulfonylureas
|
| |
Exenatide | | vs placebo (add on SU+/-MET/TZD) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.35 [0.01 17.82] | p=1.00 | 0 | 155 | 1 | Kadowaki (trial 8683), | all hypoglycemia | no data | severe hypoglycemia | 0.36 [0.01 18.47] | p=1.00 | 0 | 151 | 1 | Kadowaki (trial 8683), | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 14.77 [0.87 250.43] | p=1.00 | 0 | 151 | 1 | Kadowaki (trial 8683), | vomiting | no data | diarrhoea | no data | All cause death | 0.36 [0.01 18.47] | p=1.00 | 0 | 151 | 1 | Kadowaki (trial 8683), | cardiovascular events | 0.36 [0.01 18.47] | p=1.00 | 0 | 151 | 1 | Kadowaki (trial 8683), |
Trial | Studied treatment | Control | Patients |
---|
Kadowaki (trial 8683), 2009 | Exenatide 10µg daily for 12 weeks | Placebo on-top of sulphonylureas +/-metformin/thiazolidinediones | Japanese patients with type 2 diabetes suboptimally controlled despite therapeutic dose of sulfonylurea, SU+biguanide or SU+thiazolidinedione |
| |
Exenatide | | vs placebo (add on SU+MET) | all hypoglycemia by 277% adverse event A CHANGER by 111% adverse event vomiting by 219% adverse event diarrhoea by 110% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | 3.77 [2.39 5.93] | p=0.04 | 0 | 488 | 1 | Kendall 20µg/d, | severe hypoglycemia | 3.07 [0.12 75.85] | p=1.00 | 0 | 488 | 1 | Kendall 20µg/d, | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 2.11 [1.59 2.80] | p=0.04 | 0 | 980 | 2 | Kendall 20µg/d, Kendall 10µg/d, | vomiting | 3.19 [1.94 5.24] | p=0.04 | 0 | 980 | 2 | Kendall 20µg/d, Kendall 10µg/d, | diarrhoea | 2.10 [1.35 3.28] | p=0.04 | 0 | 980 | 2 | Kendall 20µg/d, Kendall 10µg/d, | All cause death | 0.34 [0.01 8.43] | p=1.00 | 0 | 488 | 1 | Kendall 20µg/d, | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Kendall 20µg/d, 2005 | Exenatide 10 µg bid | Placebo on-top of sulphonylureas+metformin | patients with type 2 diabetes unable to achieve glycemic control with metformin-sulfonylurea combination therapy | Kendall 10µg/d, 2005 | Exenatide 5 µg bid
| Placebo on-top of sulphonylureas+metformin
| patients with type 2 diabetes unable to achieve glycemic control with metformin-sulfonylurea combination therapy
|
| |
Exenatide | | vs placebo (add on TZD+/-MET) | A CHANGER by 161% adverse event vomiting by 1381% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.93 [0.02 47.05] | p=1.00 | 0 | 233 | 1 | Zinman 20µg/j, | all hypoglycemia | 1.50 [0.60 3.78] | p=1.00 | 0 | 233 | 1 | Zinman 20µg/j, | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 2.61 [1.39 4.92] | p=0.04 | 0 | 233 | 1 | Zinman 20µg/j, | vomiting | 14.81 [1.93 113.65] | p=0.04 | 0 | 233 | 1 | Zinman 20µg/j, | diarrhoea | 2.16 [0.54 8.57] | p=1.00 | 0 | 233 | 1 | Zinman 20µg/j, | All cause death | 0.93 [0.02 47.05] | p=1.00 | 0 | 233 | 1 | Zinman 20µg/j, | cardiovascular events | 0.93 [0.02 47.05] | p=1.00 | 0 | 233 | 1 | Zinman 20µg/j, |
Trial | Studied treatment | Control | Patients |
---|
Zinman 20µg/j, 2007 | Exenatide 20 µg daily
| Placebo on-top of thiazolidinediones+/-metformin
| patients with type 2 diabetes that was suboptimally controlled with TZD treatment (with or without metformin)
| Zinman 20µg/j A MODIFIER, 2007 | exenatide Subcutaneous abdominal injections of 10 microg twice daily | placebo | patients with type 2 diabetes that was suboptimally controlled with TZD treatment (with or without metformin) |
| |
Exenatide | | vs insulin (add on SU+MET) | A CHANGER by 563% adverse event vomiting by 364% adverse event diarrhoea by 184% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.95 [0.02 47.89] | p=1.00 | 0 | 549 | 1 | Heine, | all hypoglycemia | no data | severe hypoglycemia | 0.95 [0.23 3.82] | p=1.00 | 0 | 549 | 1 | Heine, | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 6.63 [4.07 10.80] | p=0.04 | 0 | 549 | 1 | Heine, | vomiting | 4.64 [2.30 9.37] | p=0.04 | 0 | 549 | 1 | Heine, | diarrhoea | 2.84 [1.25 6.44] | p=0.04 | 0 | 549 | 1 | Heine, | All cause death | 0.95 [0.02 47.89] | p=1.00 | 0 | 549 | 1 | Heine, | cardiovascular events | 1.58 [0.37 6.67] | p=1.00 | 0 | 549 | 1 | Heine, |
Trial | Studied treatment | Control | Patients |
---|
Heine, 2005 | Exenatide 20 µg daily | Insulin on-top of sulphonylureas+metformin | |
| |
Exenatide | | vs insulin (add on SU/MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | 1.05 [0.31 3.59] | p=1.00 | 0 | 49 | 1 | Davis, | severe hypoglycemia | 1.45 [0.06 37.81] | p=1.00 | 0 | 49 | 1 | Davis, | treatment-emergent adverse events (TEAEs) | 1.40 [0.38 5.10] | p=1.00 | 0 | 49 | 1 | Davis, | serious adverse events | no data | severe adverse events | no data | A CHANGER | 3.88 [0.76 19.82] | p=1.00 | 0 | 49 | 1 | Davis, | vomiting | 3.88 [0.44 34.15] | p=1.00 | 0 | 49 | 1 | Davis, | diarrhoea | 8.24 [0.44 153.18] | p=1.00 | 0 | 49 | 1 | Davis, | All cause death | 0.48 [0.01 25.60] | p=1.00 | 0 | 49 | 1 | Davis, | cardiovascular events | 1.45 [0.06 37.81] | p=1.00 | 0 | 49 | 1 | Davis, |
Trial | Studied treatment | Control | Patients |
---|
Davis, 2007 | Exenatide 20 µg daily | Insulin on-top of sulphonylureas/metformin | patients with type 2 diabetes using insulin in combination with oral antidiabetes agents |
| |
Exenatide | | vs insulin BIAsp twice daily add on SU+MET | A CHANGER by 8134% adverse event vomiting by 366% adverse event diarrhoea by 371% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.98 [0.06 15.76] | p=1.00 | 0 | 501 | 1 | Nauck, | all hypoglycemia | no data | severe hypoglycemia | 0.98 [0.02 49.60] | p=1.00 | 0 | 501 | 1 | Nauck, | treatment-emergent adverse events (TEAEs) | 1.43 [0.99 2.06] | p=1.00 | 0 | 501 | 1 | Nauck, | serious adverse events | 1.69 [0.79 3.64] | p=1.00 | 0 | 501 | 1 | Nauck, | severe adverse events | no data | A CHANGER | 82.34 [11.35 597.15] | p=0.04 | 0 | 501 | 1 | Nauck, | vomiting | 4.66 [2.13 10.20] | p=0.04 | 0 | 501 | 1 | Nauck, | diarrhoea | 4.71 [1.77 12.54] | p=0.04 | 0 | 501 | 1 | Nauck, | All cause death | 1.96 [0.18 21.76] | p=1.00 | 0 | 501 | 1 | Nauck, | cardiovascular events | 1.96 [0.66 5.82] | p=1.00 | 0 | 501 | 1 | Nauck, |
Trial | Studied treatment | Control | Patients |
---|
Nauck, 2007 | Exenatide 20 µg daily | Insulin on-top of sulphonylureas+metformin | patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin |
| |
Exenatide | diabetes type 2, in patients inadequately controlled with insulin | vs placebo (add on insulin) | A CHANGER by 399% adverse event vomiting by 345% adverse event diarrhoea by 123% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | 0.30 [0.01 7.36] | p=1.00 | 0 | 259 | 1 | Buse, | treatment-emergent adverse events (TEAEs) | 1.13 [0.64 1.99] | p=1.00 | 0 | 259 | 1 | Buse, | serious adverse events | no data | severe adverse events | 0.65 [0.25 1.67] | p=1.00 | 0 | 259 | 1 | Buse, | A CHANGER | 4.99 [2.40 10.36] | p=0.04 | 0 | 259 | 1 | Buse, | vomiting | 4.45 [1.65 12.04] | p=0.04 | 0 | 259 | 1 | Buse, | diarrhoea | 2.23 [1.02 4.85] | p=0.04 | 0 | 259 | 1 | Buse, | All cause death | 0.30 [0.01 7.36] | p=1.00 | 0 | 259 | 1 | Buse, | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Buse, 2011 | twice-daily 10 µg exenatide injections | placebo (on top insulin glargine) | Adults with type 2 diabetes and an HbA1c level of 7.1% to 10.5% who were receiving insulin glargine alone or in combination with metformin or pioglitazone (or both agents) |
| |
Exenatide | | vs insulin (add on SU+MET) | A CHANGER by 563% adverse event vomiting by 364% adverse event diarrhoea by 184% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.95 [0.02 47.89] | p=1.00 | 0 | 549 | 1 | Heine, | all hypoglycemia | no data | severe hypoglycemia | 0.95 [0.23 3.82] | p=1.00 | 0 | 549 | 1 | Heine, | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 6.63 [4.07 10.80] | p=0.04 | 0 | 549 | 1 | Heine, | vomiting | 4.64 [2.30 9.37] | p=0.04 | 0 | 549 | 1 | Heine, | diarrhoea | 2.84 [1.25 6.44] | p=0.04 | 0 | 549 | 1 | Heine, | All cause death | 0.95 [0.02 47.89] | p=1.00 | 0 | 549 | 1 | Heine, | cardiovascular events | 1.58 [0.37 6.67] | p=1.00 | 0 | 549 | 1 | Heine, |
Trial | Studied treatment | Control | Patients |
---|
Heine, 2005 | Exenatide 20 µg daily | Insulin on-top of sulphonylureas+metformin | |
| |
Exenatide | | vs insulin (add on SU/MET) | A CHANGER by 838% adverse event vomiting by 220% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | 0.66 [0.38 1.14] | p=1.00 | 0 | 312 | 2 | Davis, Barnett, | severe hypoglycemia | 0.40 [0.04 3.55] | p=1.00 | 0 | 312 | 2 | Davis, Barnett, | treatment-emergent adverse events (TEAEs) | 1.40 [0.38 5.10] | p=1.00 | 0 | 49 | 1 | Davis, | serious adverse events | no data | severe adverse events | no data | A CHANGER | 9.38 [3.87 22.71] | p=0.04 | 0 | 312 | 2 | Davis, Barnett, | vomiting | 3.20 [1.16 8.84] | p=0.04 | 0 | 312 | 2 | Davis, Barnett, | diarrhoea | 1.86 [0.48 7.15] | p=1.00 | 0 | 312 | 2 | Davis, Barnett, | All cause death | 0.68 [0.04 11.00] | p=1.00 | 0 | 312 | 2 | Davis, Barnett, | cardiovascular events | 1.21 [0.10 14.90] | p=1.00 | 0 | 312 | 2 | Davis, Barnett, |
Trial | Studied treatment | Control | Patients |
---|
Davis, 2007 | Exenatide 20 µg daily | Insulin on-top of sulphonylureas/metformin | patients with type 2 diabetes using insulin in combination with oral antidiabetes agents | Barnett, 2007 | Exenatide 20 µg daily | Insulin | patients with type 2 diabetes |
| |
Exenatide | | vs insulin BIAsp twice daily add on SU+MET | A CHANGER by 8134% adverse event vomiting by 366% adverse event diarrhoea by 371% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.98 [0.06 15.76] | p=1.00 | 0 | 501 | 1 | Nauck, | all hypoglycemia | no data | severe hypoglycemia | 0.98 [0.02 49.60] | p=1.00 | 0 | 501 | 1 | Nauck, | treatment-emergent adverse events (TEAEs) | 1.43 [0.99 2.06] | p=1.00 | 0 | 501 | 1 | Nauck, | serious adverse events | 1.69 [0.79 3.64] | p=1.00 | 0 | 501 | 1 | Nauck, | severe adverse events | no data | A CHANGER | 82.34 [11.35 597.15] | p=0.04 | 0 | 501 | 1 | Nauck, | vomiting | 4.66 [2.13 10.20] | p=0.04 | 0 | 501 | 1 | Nauck, | diarrhoea | 4.71 [1.77 12.54] | p=0.04 | 0 | 501 | 1 | Nauck, | All cause death | 1.96 [0.18 21.76] | p=1.00 | 0 | 501 | 1 | Nauck, | cardiovascular events | 1.96 [0.66 5.82] | p=1.00 | 0 | 501 | 1 | Nauck, |
Trial | Studied treatment | Control | Patients |
---|
Nauck, 2007 | Exenatide 20 µg daily | Insulin on-top of sulphonylureas+metformin | patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin |
| |
Exenatide | | vs insulin glargine | A CHANGER by 857% adverse event diarrhoea by 139% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.96 [0.02 48.45] | p=1.00 | 0 | 456 | 1 | DURATION-3 (Diamant), | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | 1.14 [0.77 1.68] | p=1.00 | 0 | 456 | 1 | DURATION-3 (Diamant), | serious adverse events | 1.05 [0.44 2.53] | p=1.00 | 0 | 456 | 1 | DURATION-3 (Diamant), | severe adverse events | no data | A CHANGER | 9.57 [2.88 31.84] | p=0.04 | 0 | 456 | 1 | DURATION-3 (Diamant), | vomiting | 3.19 [0.87 11.75] | p=1.00 | 0 | 456 | 1 | DURATION-3 (Diamant), | diarrhoea | 2.39 [1.03 5.55] | p=0.04 | 0 | 456 | 1 | DURATION-3 (Diamant), | All cause death | 0.96 [0.02 48.45] | p=1.00 | 0 | 456 | 1 | DURATION-3 (Diamant), | cardiovascular events | 2.87 [0.12 70.86] | p=1.00 | 0 | 456 | 1 | DURATION-3 (Diamant), |
Trial | Studied treatment | Control | Patients |
---|
DURATION-3 (Diamant), 2010 | exenatide (2 mg, once-a-week injection) | insulin glargine once-daily injection | adults with type 2 diabetes who had suboptimum glycaemic control despite use of maximum tolerated doses of blood-glucose-lowering drugs for 3 months or longer |
| |
Exenatide | | vs insulin glargine (add on MET/SU) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Trial 8078, | exenatide | Insulin Glargine | Patients with Type 2 Diabetes Using Metformin or Sulfonylurea for Whom Insulin Is the Next Appropriate Therapy |
| |
Exenatide | diabetes type 2, in Patients inadequately controlled on MET+SU therapy | vs placebo (add on SU+MET) | all hypoglycemia by 277% adverse event A CHANGER by 111% adverse event vomiting by 219% adverse event diarrhoea by 110% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | 3.77 [2.39 5.93] | p=0.04 | 0 | 488 | 1 | Kendall 20µg/d, | severe hypoglycemia | 3.07 [0.12 75.85] | p=1.00 | 0 | 488 | 1 | Kendall 20µg/d, | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 2.11 [1.59 2.80] | p=0.04 | 0 | 980 | 2 | Kendall 20µg/d, Kendall 10µg/d, | vomiting | 3.19 [1.94 5.24] | p=0.04 | 0 | 980 | 2 | Kendall 20µg/d, Kendall 10µg/d, | diarrhoea | 2.10 [1.35 3.28] | p=0.04 | 0 | 980 | 2 | Kendall 20µg/d, Kendall 10µg/d, | All cause death | 0.34 [0.01 8.43] | p=1.00 | 0 | 488 | 1 | Kendall 20µg/d, | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Kendall 20µg/d, 2005 | Exenatide 10 µg bid | Placebo on-top of sulphonylureas+metformin | patients with type 2 diabetes unable to achieve glycemic control with metformin-sulfonylurea combination therapy | Kendall 10µg/d, 2005 | Exenatide 5 µg bid
| Placebo on-top of sulphonylureas+metformin
| patients with type 2 diabetes unable to achieve glycemic control with metformin-sulfonylurea combination therapy
|
| |
Exenatide | | vs insulin (add on SU+MET) | A CHANGER by 563% adverse event vomiting by 364% adverse event diarrhoea by 184% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.95 [0.02 47.89] | p=1.00 | 0 | 549 | 1 | Heine, | all hypoglycemia | no data | severe hypoglycemia | 0.95 [0.23 3.82] | p=1.00 | 0 | 549 | 1 | Heine, | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 6.63 [4.07 10.80] | p=0.04 | 0 | 549 | 1 | Heine, | vomiting | 4.64 [2.30 9.37] | p=0.04 | 0 | 549 | 1 | Heine, | diarrhoea | 2.84 [1.25 6.44] | p=0.04 | 0 | 549 | 1 | Heine, | All cause death | 0.95 [0.02 47.89] | p=1.00 | 0 | 549 | 1 | Heine, | cardiovascular events | 1.58 [0.37 6.67] | p=1.00 | 0 | 549 | 1 | Heine, |
Trial | Studied treatment | Control | Patients |
---|
Heine, 2005 | Exenatide 20 µg daily | Insulin on-top of sulphonylureas+metformin | |
| |
Exenatide | | vs insulin BIAsp twice daily add on SU+MET | A CHANGER by 8134% adverse event vomiting by 366% adverse event diarrhoea by 371% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.98 [0.06 15.76] | p=1.00 | 0 | 501 | 1 | Nauck, | all hypoglycemia | no data | severe hypoglycemia | 0.98 [0.02 49.60] | p=1.00 | 0 | 501 | 1 | Nauck, | treatment-emergent adverse events (TEAEs) | 1.43 [0.99 2.06] | p=1.00 | 0 | 501 | 1 | Nauck, | serious adverse events | 1.69 [0.79 3.64] | p=1.00 | 0 | 501 | 1 | Nauck, | severe adverse events | no data | A CHANGER | 82.34 [11.35 597.15] | p=0.04 | 0 | 501 | 1 | Nauck, | vomiting | 4.66 [2.13 10.20] | p=0.04 | 0 | 501 | 1 | Nauck, | diarrhoea | 4.71 [1.77 12.54] | p=0.04 | 0 | 501 | 1 | Nauck, | All cause death | 1.96 [0.18 21.76] | p=1.00 | 0 | 501 | 1 | Nauck, | cardiovascular events | 1.96 [0.66 5.82] | p=1.00 | 0 | 501 | 1 | Nauck, |
Trial | Studied treatment | Control | Patients |
---|
Nauck, 2007 | Exenatide 20 µg daily | Insulin on-top of sulphonylureas+metformin | patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin |
| |
Exenatide | diabetes type 2, in patients inadequately controlled on metformin | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | 4.50 [0.23 89.67] | p=1.00 | 0 | 45 | 1 | Kim, | severe hypoglycemia | 0.72 [0.04 11.74] | p=1.00 | 0 | 268 | 2 | DeFronzo 10µg/d, Kim, | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 1.67 [0.95 2.93] | p=1.00 | 0 | 268 | 2 | DeFronzo 10µg/d, Kim, | vomiting | 2.67 [0.87 8.15] | p=1.00 | 0 | 268 | 2 | DeFronzo 10µg/d, Kim, | diarrhoea | 1.48 [0.61 3.63] | p=1.00 | 0 | 223 | 1 | DeFronzo 10µg/d, | All cause death | 0.72 [0.04 11.74] | p=1.00 | 0 | 268 | 2 | DeFronzo 10µg/d, Kim, | cardiovascular events | 0.50 [0.01 26.49] | p=1.00 | 0 | 45 | 1 | Kim, |
Trial | Studied treatment | Control | Patients |
---|
DeFronzo 10µg/d, 2005 | Exenatide 10–20 µg daily | Placebo on-top of Metformin | patients with type 2 diabetes failing to achieve glycemic control with maximally effective metformin doses | Kim, 2007 | exenatide LAR 0.8 or 2 µg daily | Placebo on-top of metformin | subjects with type 2 diabetes suboptimally controlled with metformin and/or diet and exercise | DeFronzo 20µg/d, 2005 | Exenatide 10–20 µg daily | Placebo on-top of Metformin | patients with type 2 diabetes failing to achieve glycemic control with maximally effective metformin doses |
| |
Exenatide | | vs placebo (add on MET+/-SU) | all hypoglycemia by 292% adverse event treatment-emergent adverse events (TEAEs) by 58% adverse event A CHANGER by 2825% adverse event vomiting by 7336% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.99 [0.02 50.18] | p=1.00 | 0 | 466 | 1 | Gao, | all hypoglycemia | 3.92 [2.32 6.61] | p=0.04 | 0 | 466 | 1 | Gao, | severe hypoglycemia | 1.98 [0.18 22.02] | p=1.00 | 0 | 466 | 1 | Gao, | treatment-emergent adverse events (TEAEs) | 1.58 [1.09 2.30] | p=0.04 | 0 | 466 | 1 | Gao, | serious adverse events | no data | severe adverse events | no data | A CHANGER | 29.25 [7.05 121.35] | p=0.04 | 0 | 466 | 1 | Gao, | vomiting | 74.36 [4.54 1218.83] | p=0.04 | 0 | 466 | 1 | Gao, | diarrhoea | 1.49 [0.52 4.25] | p=1.00 | 0 | 466 | 1 | Gao, | All cause death | 0.99 [0.02 50.18] | p=1.00 | 0 | 466 | 1 | Gao, | cardiovascular events | 0.20 [0.01 4.15] | p=1.00 | 0 | 466 | 1 | Gao, |
Trial | Studied treatment | Control | Patients |
---|
Gao, 2009 | exenatide 5 mg then 10 mg twice-daily for 4 and 12 weeks | placebo
| Asian desccent with type 2 diabetes and inadequate glycemic control taking
metformin alone or Met and sulfonylureas
|
| |
Exenatide | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on MER+/-SU) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Fineman, 2003 | exenatide 3 regimen (0.08 micro g/kg) for 28 days | placebo | patients with tyep 2 diabetes treated with diet and a sulfonylurea and/or metformin |
| |
Exenatide | | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | 4.50 [0.23 89.67] | p=1.00 | 0 | 45 | 1 | Kim, | severe hypoglycemia | 0.72 [0.04 11.74] | p=1.00 | 0 | 268 | 2 | DeFronzo 10µg/d, Kim, | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 1.67 [0.95 2.93] | p=1.00 | 0 | 268 | 2 | DeFronzo 10µg/d, Kim, | vomiting | 2.67 [0.87 8.15] | p=1.00 | 0 | 268 | 2 | DeFronzo 10µg/d, Kim, | diarrhoea | 1.48 [0.61 3.63] | p=1.00 | 0 | 223 | 1 | DeFronzo 10µg/d, | All cause death | 0.72 [0.04 11.74] | p=1.00 | 0 | 268 | 2 | DeFronzo 10µg/d, Kim, | cardiovascular events | 0.50 [0.01 26.49] | p=1.00 | 0 | 45 | 1 | Kim, |
Trial | Studied treatment | Control | Patients |
---|
DeFronzo 10µg/d, 2005 | Exenatide 10–20 µg daily | Placebo on-top of Metformin | patients with type 2 diabetes failing to achieve glycemic control with maximally effective metformin doses | Kim, 2007 | exenatide LAR 0.8 or 2 µg daily | Placebo on-top of metformin | subjects with type 2 diabetes suboptimally controlled with metformin and/or diet and exercise | DeFronzo 20µg/d, 2005 | Exenatide 10–20 µg daily | Placebo on-top of Metformin | patients with type 2 diabetes failing to achieve glycemic control with maximally effective metformin doses |
| |
Exenatide | | vs placebo (add on MET+/-SU) | all hypoglycemia by 292% adverse event treatment-emergent adverse events (TEAEs) by 58% adverse event A CHANGER by 2825% adverse event vomiting by 7336% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | 0.99 [0.02 50.18] | p=1.00 | 0 | 466 | 1 | Gao, | all hypoglycemia | 3.92 [2.32 6.61] | p=0.04 | 0 | 466 | 1 | Gao, | severe hypoglycemia | 1.98 [0.18 22.02] | p=1.00 | 0 | 466 | 1 | Gao, | treatment-emergent adverse events (TEAEs) | 1.58 [1.09 2.30] | p=0.04 | 0 | 466 | 1 | Gao, | serious adverse events | no data | severe adverse events | no data | A CHANGER | 29.25 [7.05 121.35] | p=0.04 | 0 | 466 | 1 | Gao, | vomiting | 74.36 [4.54 1218.83] | p=0.04 | 0 | 466 | 1 | Gao, | diarrhoea | 1.49 [0.52 4.25] | p=1.00 | 0 | 466 | 1 | Gao, | All cause death | 0.99 [0.02 50.18] | p=1.00 | 0 | 466 | 1 | Gao, | cardiovascular events | 0.20 [0.01 4.15] | p=1.00 | 0 | 466 | 1 | Gao, |
Trial | Studied treatment | Control | Patients |
---|
Gao, 2009 | exenatide 5 mg then 10 mg twice-daily for 4 and 12 weeks | placebo
| Asian desccent with type 2 diabetes and inadequate glycemic control taking
metformin alone or Met and sulfonylureas
|
| |
Exenatide | | vs placebo (add on SU) | A CHANGER by 436% adverse event vomiting by 294% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | 0.98 [0.02 49.99] | p=1.00 | 0 | 248 | 1 | Buse 10µg/d, | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 5.36 [2.49 11.54] | p=0.04 | 0 | 248 | 1 | Buse 10µg/d, | vomiting | 3.94 [1.08 14.31] | p=0.04 | 0 | 248 | 1 | Buse 10µg/d, | diarrhoea | 2.76 [0.96 7.90] | p=1.00 | 0 | 248 | 1 | Buse 10µg/d, | All cause death | 0.98 [0.02 49.99] | p=1.00 | 0 | 248 | 1 | Buse 10µg/d, | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Buse 10µg/d, 2004 | Exenatide 5µg twice daily | Placebo on-top of SU | patients with type 2 diabetes failing maximally effective doses of a sulfonylurea as monotherapy | Buse 20µg/d, 2004 | Exenatide 10µg twice daily
| Placebo on-top of SU
| patients with type 2 diabetes failing maximally effective doses of a sulfonylurea as monotherapy
|
| |
Exenatide | | vs exenatide before breakfast and dinner | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Exenatide Trial 10749, | exenatide (10 ìg twice daily)
administered subcutaneously before lunch and dinner | exenatide (10 ìg twice daily)
administered subcutaneously before breakfast and dinner | patients with type 2 Diabetes using oral antidiabetic therapy |
| |
Exenatide | | vs insulin glargine (add on MET/SU) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Trial 8078, | exenatide | Insulin Glargine | Patients with Type 2 Diabetes Using Metformin or Sulfonylurea for Whom Insulin Is the Next Appropriate Therapy |
| |
Liraglutide | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
LEAD-2 (Nauck) (1.8mg vs placebo), 2009 | Liraglutide 1.8 mg daily
| Placebo on-top of Metformin
| subjects previously treated with oral antidiabetes therapy
|
| |
Liraglutide | | vs placebo (add on SU) | A CHANGER by 330% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | 0.50 [0.02 12.26] | p=1.00 | 0 | 810 | 1 | LEAD-1 SU (1.2 mg vs placebo), | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 4.30 [1.03 17.91] | p=0.04 | 0 | 810 | 1 | LEAD-1 SU (1.2 mg vs placebo), | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
LEAD-1 SU (1.2 mg vs placebo), 2009 | Liraglutide 1.2 mg daily
| Placebo on-top of sulphonylureas
| subjects with
Type 2 diabetes
| LEAD-1 SU (1.8 mg vs placebo), 2009 | Liraglutide 1.8 mg daily
| Placebo on-top of sulphonylureas
| patients with type 2 diabetes
|
| |
Liraglutide | | vs placebo (add on SU+MET) | A CHANGER by 297% adverse event diarrhoea by 280% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 3.97 [1.37 11.51] | p=0.04 | 0 | 344 | 1 | LEAD-5 (vs placebo), | vomiting | 1.86 [0.60 5.73] | p=1.00 | 0 | 344 | 1 | LEAD-5 (vs placebo), | diarrhoea | 3.80 [1.12 12.94] | p=0.04 | 0 | 344 | 1 | LEAD-5 (vs placebo), | All cause death | no data | cardiovascular events | 2.48 [0.29 21.47] | p=1.00 | 0 | 347 | 1 | LEAD-5 (vs placebo), |
Trial | Studied treatment | Control | Patients |
---|
LEAD-5 (vs placebo), 2009 | Liraglutide 1.8 mg daily
| Placebo on-top of sulphonylureas+metformin
| adult patients with type 2 diabetes
|
| |
Liraglutide | | vs glimepiride (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
LEAD-2 (Nauck) (1.8 mg vs glimepiride), 2009 | Liraglutide 1.8 mg daily for 26 weeks
| Glimepiride on-top of Metformin
| patients with type 3 diabetes previously treated with oral antidiabetes (OAD) therap
|
| |
Liraglutide | | vs insulin glargine (add on SU+MET) | A CHANGER by 976% adverse event vomiting by 1413% adverse event diarrhoea by 673% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 10.76 [3.25 35.67] | p=0.04 | 0 | 462 | 1 | LEAD-5 (vs Glargine), | vomiting | 15.13 [1.98 115.53] | p=0.04 | 0 | 462 | 1 | LEAD-5 (vs Glargine), | diarrhoea | 7.73 [2.29 26.14] | p=0.04 | 0 | 462 | 1 | LEAD-5 (vs Glargine), | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
LEAD-5 (vs Glargine), 2009 | Liraglutide 1.8 mg daily | Glargine on-top of sulphonylureas+metformin | adult patients with type 2 diabetes |
| |
Liraglutide | | vs rosiglitazone (add on SU) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
LEAD-1 SU (1.8 vs rosiglitazone), 2009 | Liraglutide 0.6, 1.2 or 1.8 mg daily
| rosiglitazone on-top of sulphonylureas
|
|
| |
Liraglutide | | vs glibenclamide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | 0.49 [0.01 24.96] | p=1.00 | 0 | 400 | 1 | Seino, | treatment-emergent adverse events (TEAEs) | 0.99 [0.61 1.58] | p=1.00 | 0 | 400 | 1 | Seino, | serious adverse events | 0.80 [0.32 1.98] | p=1.00 | 0 | 400 | 1 | Seino, | severe adverse events | 1.48 [0.29 7.42] | p=1.00 | 0 | 400 | 1 | Seino, | A CHANGER | no data | vomiting | no data | diarrhoea | 1.67 [0.60 4.64] | p=1.00 | 0 | 400 | 1 | Seino, | All cause death | 1.48 [0.06 36.52] | p=1.00 | 0 | 400 | 1 | Seino, | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Seino, 2010 | liraglutide 0.9 mg once daily | glibenclamide once or twice daily at a planned maximum dose of 2.5 mg/day, before or after meals | Japanese subjects with type 2 diabetes, inadequately controlled with diet therapy or oral antidiabetic drug monotherapy |
| |
Liraglutide | | vs sitagliptin | A CHANGER by 421% adverse event vomiting by 110% adverse event diarrhoea by 103% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | 1.50 [0.61 3.70] | p=1.00 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | severe adverse events | 0.87 [0.42 1.81] | p=1.00 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | A CHANGER | 5.21 [3.16 8.59] | p=0.04 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | vomiting | 2.10 [1.18 3.75] | p=0.04 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | diarrhoea | 2.03 [1.16 3.53] | p=0.04 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | All cause death | 0.62 [0.08 5.09] | p=1.00 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | cardiovascular events | 0.97 [0.14 6.94] | p=1.00 | 0 | 888 | 2 | Pratley 1.2mg, Pratley 1.8mg, |
Trial | Studied treatment | Control | Patients |
---|
Pratley 1.2mg, 2010 | liraglutide 1.2mg subcutaneously once daily | oral sitagliptin 100mg once daily | patients with type 2 diabetes who did not have adequate glycemic control with metformin | Pratley 1.8mg, 2010 | liraglutide 1.8mg subcutaneously once daily
| oral sitagliptin 100mg once daily
| patients with type 2 diabetes who did not have adequate glycemic control with metformin
|
| |
Liraglutide | diabetes type 2, in patients with insufficient glycaemic control with bitherapy | vs placebo (add on TZD+MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | 0.99 [0.02 50.40] | p=1.00 | 0 | 355 | 1 | LEAD-4 (1.2mg), | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | 0.99 [0.37 2.70] | p=1.00 | 0 | 710 | 2 | LEAD-4 (1.2mg), LEAD-4 (1.8mg), |
Trial | Studied treatment | Control | Patients |
---|
LEAD-4 (1.2mg), 2009 | Liraglutide 1.2 daily | Placebo on-top of thiazolidinediones + metformin | patients with type 2 diabetes, A1C 7–11% (previous OAD
monotherapy >=3 months) or 7–10% (previous OAD combination therapy >=3 months),
and BMI 45 kg/m2 | LEAD-4 (1.8mg), 2009 | Liraglutide 1.8 daily
| Placebo on-top of thiazolidinediones + metformin
| patients with type 2 diabetes, A1C 7–11% (previous OAD
monotherapy >=3 months) or 7–10% (previous OAD combination therapy >=3 months),
and BMI 45 kg/m2
|
| |
Liraglutide | | vs exenatide on top MET/SU/MET+SU | severe adverse events by 180% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | 0.20 [0.01 4.15] | p=1.00 | 0 | 464 | 1 | LEAD-6, | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | 1.97 [0.73 5.35] | p=1.00 | 0 | 467 | 1 | LEAD-6, | severe adverse events | 2.80 [1.08 7.23] | p=0.04 | 0 | 467 | 1 | LEAD-6, | A CHANGER | 0.91 [0.60 1.37] | p=1.00 | 0 | 467 | 1 | LEAD-6, | vomiting | 0.60 [0.30 1.20] | p=1.00 | 0 | 467 | 1 | LEAD-6, | diarrhoea | 1.02 [0.59 1.78] | p=1.00 | 0 | 467 | 1 | LEAD-6, | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
LEAD-6, 2009 | liraglutide 1.8 mg once a day | exenatide 10 microg twice a day | Adults with inadequately controlled type 2 diabetes on maximally tolerated doses of metformin, sulphonylurea, or both |
| |
Liraglutide | diabetes type 2, in Patients inadequately controlled on MET+SU therapy | vs placebo (add on SU+MET) | A CHANGER by 297% adverse event diarrhoea by 280% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 3.97 [1.37 11.51] | p=0.04 | 0 | 344 | 1 | LEAD-5 (vs placebo), | vomiting | 1.86 [0.60 5.73] | p=1.00 | 0 | 344 | 1 | LEAD-5 (vs placebo), | diarrhoea | 3.80 [1.12 12.94] | p=0.04 | 0 | 344 | 1 | LEAD-5 (vs placebo), | All cause death | no data | cardiovascular events | 2.48 [0.29 21.47] | p=1.00 | 0 | 347 | 1 | LEAD-5 (vs placebo), |
Trial | Studied treatment | Control | Patients |
---|
LEAD-5 (vs placebo), 2009 | Liraglutide 1.8 mg daily
| Placebo on-top of sulphonylureas+metformin
| adult patients with type 2 diabetes
|
| |
Liraglutide | | vs insulin glargine (add on SU+MET) | A CHANGER by 976% adverse event vomiting by 1413% adverse event diarrhoea by 673% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | 10.76 [3.25 35.67] | p=0.04 | 0 | 462 | 1 | LEAD-5 (vs Glargine), | vomiting | 15.13 [1.98 115.53] | p=0.04 | 0 | 462 | 1 | LEAD-5 (vs Glargine), | diarrhoea | 7.73 [2.29 26.14] | p=0.04 | 0 | 462 | 1 | LEAD-5 (vs Glargine), | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
LEAD-5 (vs Glargine), 2009 | Liraglutide 1.8 mg daily | Glargine on-top of sulphonylureas+metformin | adult patients with type 2 diabetes |
| |
Liraglutide | | vs exenatide on top MET/SU/MET+SU | severe adverse events by 180% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | 0.20 [0.01 4.15] | p=1.00 | 0 | 464 | 1 | LEAD-6, | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | 1.97 [0.73 5.35] | p=1.00 | 0 | 467 | 1 | LEAD-6, | severe adverse events | 2.80 [1.08 7.23] | p=0.04 | 0 | 467 | 1 | LEAD-6, | A CHANGER | 0.91 [0.60 1.37] | p=1.00 | 0 | 467 | 1 | LEAD-6, | vomiting | 0.60 [0.30 1.20] | p=1.00 | 0 | 467 | 1 | LEAD-6, | diarrhoea | 1.02 [0.59 1.78] | p=1.00 | 0 | 467 | 1 | LEAD-6, | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
LEAD-6, 2009 | liraglutide 1.8 mg once a day | exenatide 10 microg twice a day | Adults with inadequately controlled type 2 diabetes on maximally tolerated doses of metformin, sulphonylurea, or both |
| |
Liraglutide | diabetes type 2, in patients inadequately controlled on metformin | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
LEAD-2 (Nauck) (1.8mg vs placebo), 2009 | Liraglutide 1.8 mg daily
| Placebo on-top of Metformin
| subjects previously treated with oral antidiabetes therapy
|
| |
Liraglutide | | vs glimepiride (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
LEAD-2 (Nauck) (1.8 mg vs glimepiride), 2009 | Liraglutide 1.8 mg daily for 26 weeks
| Glimepiride on-top of Metformin
| patients with type 3 diabetes previously treated with oral antidiabetes (OAD) therap
|
| |
Liraglutide | | vs sitagliptin | A CHANGER by 421% adverse event vomiting by 110% adverse event diarrhoea by 103% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | 1.50 [0.61 3.70] | p=1.00 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | severe adverse events | 0.87 [0.42 1.81] | p=1.00 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | A CHANGER | 5.21 [3.16 8.59] | p=0.04 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | vomiting | 2.10 [1.18 3.75] | p=0.04 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | diarrhoea | 2.03 [1.16 3.53] | p=0.04 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | All cause death | 0.62 [0.08 5.09] | p=1.00 | 0 | 877 | 2 | Pratley 1.2mg, Pratley 1.8mg, | cardiovascular events | 0.97 [0.14 6.94] | p=1.00 | 0 | 888 | 2 | Pratley 1.2mg, Pratley 1.8mg, |
Trial | Studied treatment | Control | Patients |
---|
Pratley 1.2mg, 2010 | liraglutide 1.2mg subcutaneously once daily | oral sitagliptin 100mg once daily | patients with type 2 diabetes who did not have adequate glycemic control with metformin | Pratley 1.8mg, 2010 | liraglutide 1.8mg subcutaneously once daily
| oral sitagliptin 100mg once daily
| patients with type 2 diabetes who did not have adequate glycemic control with metformin
|
| |
Taspoglutide | diabetes type 2, in patients inadequately controlled on metformin | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Ratner (20mg once weekly), 2010 | taspoglutide s.c. 20mg once weekly for 8 weeks | placebo s.c. once
weekly on top metformin | subjects with Type 2 diabetes inadequately controlled on metformin alone |
| |
Taspoglutide | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Nauck 10 once weekly vs PBO, 2009 | taspoglutide, either 5, 10, or 20 mg once weekly or 10 or 20 mg once every 2 weeks for 8 weeks | placebo | patients with type 2 diabetes inadequately controlled with metformin |
| |
Taspoglutide | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Ratner (20mg once weekly), 2010 | taspoglutide s.c. 20mg once weekly for 8 weeks | placebo s.c. once
weekly on top metformin | subjects with Type 2 diabetes inadequately controlled on metformin alone |
| |
Taspoglutide | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Nauck 10 once weekly vs PBO, 2009 | taspoglutide, either 5, 10, or 20 mg once weekly or 10 or 20 mg once every 2 weeks for 8 weeks | placebo | patients with type 2 diabetes inadequately controlled with metformin |
| |
Lixisenatide | diabetes type 2, in patients inadequately controlled on metformin | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Ratner DRI6012, 2010 | subcutaneous lixisenatide doses of 5, 10, 20 or 30 microg once daily or twice daily | placebo | patients with Type 2 diabetes inadequately controlled with metformin (>= 1000 mg/day) |
| |
Lixisenatide | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | all hypoglycemia | no data | severe hypoglycemia | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | A CHANGER | no data | vomiting | no data | diarrhoea | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
Ratner DRI6012, 2010 | subcutaneous lixisenatide doses of 5, 10, 20 or 30 microg once daily or twice daily | placebo | patients with Type 2 diabetes inadequately controlled with metformin (>= 1000 mg/day) |
| |
Lixisenatide | diabetes type 2, in patients inadequately controlled with insulin | vs placebo (add on basal insulin) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Cardiovascular death | no data | treatment-emergent adverse events (TEAEs) | no data | serious adverse events | no data | severe adverse events | no data | severe hypoglycemia | no data | all hypoglycemia | no data | diarrhoea | no data | vomiting | no data | A CHANGER | no data | All cause death | no data | cardiovascular events | no data |
Trial | Studied treatment | Control | Patients |
---|
GETGOAL-L, 0 | AVE0010 (10,15 and 20 µg) in association with basal insulin, with or without metformin | placebo on top basal insulin | Type 2 diabetes mellitus insufficiently controlled with basal insulin with or without metformin |
| |
Mitiglinide | diabetes type 2, in all types of patients | vs nateglinide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Gao, 0 | mitiglinide 10 - 20 mg three times daily | nateglinide 120 mg three times daily | Chinese type 2 diabetes mellitus patients |
| |
Mitiglinide | | vs on top insulin glargine | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Kumashiro, 2007 | mitiglinide | on top of once daily insulin glargine | |
| |
Mitiglinide | | vs placebo (on top pioglitazone) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Kaku, 2009 | additional mitiglinide 5 or 10 mg tid | placebo on top pioglitazone | Japanese type 2 diabetic patients who are insufficiently controlled by pioglitazone monotherapy |
| |
Mitiglinide | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (on top pioglitazone) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Kaku, 2009 | additional mitiglinide 5 or 10 mg tid | placebo on top pioglitazone | Japanese type 2 diabetic patients who are insufficiently controlled by pioglitazone monotherapy |
| |
Nateglinide | diabetes type 2, in all types of patients | vs repaglinide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Li, 2009 | Nateglinide | repaglinide | | Li, 2007 | nateglinide 90 mg three times daily | repaglinide 1.0 mg three times daily | Chinese patients with type 2 diabetes |
| |
Nateglinide | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Marre, 2002 | nateglinide 60 mg, 120 mg before three meals | placebo | metformin-treated patients with HbA1c between 6.8% and 11% | Horton, 2000 | 120 mg nateglinide before meals | placebo | patients with an HbA1c level between 6.8 and 11.0% during a 4-week placebo run-in | Hanefeld, 1990 | nateglinide at doses of 30 mg, 60 mg, 120 mg, or 180 mg | placebo | | Saloranta, 2002 | nateglinide (30, 60, or 120 mg, with meals). | placebo | patients with type 2 diabetes but only moderately elevated fasting plasma glucose (FPG = 7.0-8.3 mmol/liter) | Mari, 2005 | 30, 60, or 120 mg nateglinide | placebo | mild type 2 diabetic men and women (fasting glucose 7.0-8.3 mmol/l) on diet treatment | Goldberg, 1998 | repaglinide | placebo | type 2 diabetes | Jovanovic, 2000 | repaglinide 1 mg or repaglinide 4 mg | placebo | | Bech, 2003 | repaglinide initiated at 0.5 mg per meal, increased to 1 mg after 4 weeks if fasting plasma glucose exceeded 7.8 mmol/l. | placebo | pharmacotherapy-naive patients with Type 2 diabetes | Moses, 2001 | 0.5 mg repaglinide at mealtimes (increased to 1 mg after 4 weeks depending on blood glucose response) | placebo | patients with type 2 diabetes considered poorly controlled by diet, but without a history of previous antidiabetic medication |
| |
Nateglinide | | vs gliclazide (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Ristic, 2006 | nateglinide plus metformin | gliclazide plus metformin | Patients with inadequate glucose control on maximal doses of metformin |
| |
Nateglinide | diabetes type 2, in patients inadequately controlled on metformin | vs gliclazide (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Ristic, 2006 | nateglinide plus metformin | gliclazide plus metformin | Patients with inadequate glucose control on maximal doses of metformin |
| |
Nateglinide | diabetes type 2, in patients inadequately controlled on monotherapy | vs gliclazide (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Ristic, 2006 | nateglinide plus metformin | gliclazide plus metformin | Patients with inadequate glucose control on maximal doses of metformin |
| |
Repaglinide | diabetes type 2, in all types of patients | vs glibenclamide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Landgraf, 1999 | repaglinide, administered preprandially three times daily | glibenclamide, given preprandially once or twice daily | | Marbury, 1999 | | | | Wolffenbuttel, 1999 | repaglinide (0.5-4 mg t.i.d.) | glyburide (1.75-10.5 mg daily) | |
| |
Repaglinide | | vs glipizide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Madsbad, 2001 | repaglinide, 1-4 mg at mealtimes | glipizide, 5-15 mg daily | |
| |
Repaglinide | | vs metformin | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Lund, 2007 | repaglinide 2 mg thrice daily | metformin 1 g twice daily | non-obese patients with type 2 diabetes |
| |
Repaglinide | | vs on top pioglitazone | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Raskin, 2001 | | | |
| |
Repaglinide | | vs on top rosiglitazone | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Raskin, 2001 | | | |
| |
Repaglinide | | vs on top troglitazone | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Raskin, 2000 | repaglinide (0.5–4.0 mg at meals), | combination of repaglinide (1–4 mg at meals) and troglitazone (200–600 mg once
daily) | Patients with type 2 diabetes who
had inadequate glycemic control (HbA1c 7.0%) during previous monotherapy |
| |
Repaglinide | | vs placebo (on top bedtime NPH-insulin) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Landin-Olsson, 1999 | | | |
| |
Repaglinide | | vs control (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Moses, 1999 | prestudy dose of metformin with the addition of repaglinide | prestudy dose of metformin | patients with type 2 diabetes who had inadequate glycemic control (HbA1c > 7.1%) when receiving the antidiabetic agent metformin |
| |
Repaglinide | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Chuang, 1999 | | | | Goldberg, 1998 | repaglinide | placebo | patients with type 2 diabetes | Jovanovic, 2000 | repaglinide 1 mg (n = 140), or repaglinide 4 mg (n = 146) | placebo | |
| |
Repaglinide | diabetes type 2, in patients inadequately controlled on metformin | vs control (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Moses, 1999 | prestudy dose of metformin with the addition of repaglinide | prestudy dose of metformin | patients with type 2 diabetes who had inadequate glycemic control (HbA1c > 7.1%) when receiving the antidiabetic agent metformin |
| |
Repaglinide | diabetes type 2, in patients inadequately controlled on monotherapy | vs control (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Moses, 1999 | prestudy dose of metformin with the addition of repaglinide | prestudy dose of metformin | patients with type 2 diabetes who had inadequate glycemic control (HbA1c > 7.1%) when receiving the antidiabetic agent metformin |
| |
Glipizide | diabetes type 2, in all types of patients | vs control (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Goldstein, | glipizide/metformin 5/500 mg tablets | metformin 500-mg | patients with type 2 DM that is uncontrolled by at least half the maximum labeled daily dose of a sulfonylurea |
| |
Glipizide | | vs glyburide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Rosenstock, 1993 | glipizide, 2.5 or 5 mg/day | glyburide, 1.25 or 2.5 mg/day | elderly patients with NIDDM that was controlled for at least 3 months with oral sulfonylurea therapy | Birkeland, 1994 | glipizide | glyburide | NIDDM patients | Birkeland, 1994 | glipizide | glyburide | NIDDM patients |
| |
Glipizide | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Simonson, 1997 | once-daily doses of 5, 20, 40, or 60 mg glipizide GITS | placebo | NIDDM patients | Testa, 1998 | 5 to 20 mg of glipizide gastrointestinal therapeutic system (GITS) | placebo | patients with type 2 diabetes mellitus |
| |
Glipizide | diabetes type 2, in patients inadequately controlled on monotherapy | vs control (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Goldstein, | glipizide/metformin 5/500 mg tablets | metformin 500-mg | patients with type 2 DM that is uncontrolled by at least half the maximum labeled daily dose of a sulfonylurea |
| |
Glipizide | | vs glyburide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Rosenstock, 1993 | glipizide, 2.5 or 5 mg/day | glyburide, 1.25 or 2.5 mg/day | elderly patients with NIDDM that was controlled for at least 3 months with oral sulfonylurea therapy |
| |
Glipizide | diabetes type 2, in patients insufficiently controlled on SU | vs glyburide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Rosenstock, 1993 | glipizide, 2.5 or 5 mg/day | glyburide, 1.25 or 2.5 mg/day | elderly patients with NIDDM that was controlled for at least 3 months with oral sulfonylurea therapy |
| |
Glyburide | diabetes type 2, in all types of patients | vs c (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Hermann, 1991 | metformin + glibenclamide | metformin | patients with non-insulin-dependent diabetes mellitus | DeFronzo, 1995 | metformin and glyburide | metformin | patients with non-insulin-dependent diabetes mellitus | Erle, 1999 | low-dose glyburide plus metformin | high-dose glyburide alone | |
| |
Glyburide | | vs control (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Marre (ass), 2002 | metformin-glibenclamide 500 mg/2.5 mg or metformin-glibenclamide 500 mg/5 mg, titrated with the intention to achieve fasting plasma glucose (FPG) < or = 7 mmol/l | metformin 500 mg, | patients with Type 2 diabetes mellitus inadequately controlled by metformin monotherapy | Blonde, 2002 | glyburide/metformin 2.5 mg/500 mg (n = 160); or glyburide/metformin 5 mg/500 mg (n = 162) | metformin 500 mg | patients with inadequate glycaemic control on at least half-maximal dose of sulphonylurea | Tosi, 2003 | metformin 400 to 2,400 mg/d + glibenclamide 2.5 to 15 mg/d | metformin (500 to 3,000 mg/d), | | Garber, 2003 | glyburide/metformin | metformin | patients with type 2 diabetes who had inadequate glycemic control [glycosylated hemoglobin A(1C) (A1C), >7% and <12%) with diet and exercise alone |
| |
Glyburide | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Garber, 2002 | glyburide 2.5 mg | placebo | patients with type 2 diabetes who had failed diet and exercise | Vray, 1995 | glibenclamide (2.5 mg X 3/d) | placebo | type 2 diabetic outpatients, 40-70 years of age, treated by diet alone or oral anti-diabetic drugs |
| |
Glyburide | diabetes type 2, in patients inadequately controlled on monotherapy | vs control (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Marre (ass), 2002 | metformin-glibenclamide 500 mg/2.5 mg or metformin-glibenclamide 500 mg/5 mg, titrated with the intention to achieve fasting plasma glucose (FPG) < or = 7 mmol/l | metformin 500 mg, | patients with Type 2 diabetes mellitus inadequately controlled by metformin monotherapy | Blonde, 2002 | glyburide/metformin 2.5 mg/500 mg (n = 160); or glyburide/metformin 5 mg/500 mg (n = 162) | metformin 500 mg | patients with inadequate glycaemic control on at least half-maximal dose of sulphonylurea |
| |
Glyburide | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Vray, 1995 | glibenclamide (2.5 mg X 3/d) | placebo | type 2 diabetic outpatients, 40-70 years of age, treated by diet alone or oral anti-diabetic drugs |
| |
Glimeripide | diabetes type 2, in all types of patients | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Study 201 (Goldberg), 1996 | glimepiride, 1, 4, or 8 mg once daily | placebo | patients with NIDDM | Schade, 1998 | glimepiride at individually determined optimal dose (1-8 mg of glimepiride) for 10+12 weeks | placebo | patients with type 2 diabetes mellitus for whom diet therapy is unsuccessful | Rosenstock, 1996 | glimepiride 8 mg q.d., 4 mg b.i.d., 16 mg q.d., or 8 mg b.i.d | placebo | previously treated NIDDM patients | Luis Bautista, 2003 | glimepiride with titration to 2 mg and 4 mg for FPG levels >120 mg/dL | placebo | Mexican American Patients with type 2 diabetes mellitus | Kaneko, 1993 | glimepiride 0.25mg od, 0.5mg od | placebo | | Study 202, | glimepiride 1-8mg od | placebo | |
| |
Glimeripide | | vs placebo (add on insulin) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Riddle, 1994 | Glimepiride (16 mg/day) plus insulin | insulin
plus placebo | obese
patients with type 2 diabetes insufficiently controlled
by full dosages of sulphonylureas (glimepiride titrated up to 8mg twice daily and with laboratory-monitored FPG of 10 to 16
mmol/L (180 to 300 mg/dl)) |
| |
Glimeripide | | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Any diabetes-related outcomes | no data | Diabetes-related death | no data | Peripheral vascular events | no data | macrovascular or microvascular events | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | microvascular events | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
Charpentier, 2001 | metformin and glimepiride | metformin | Type 2 diabetic patients aged 35-70 years inadequately controlled by metformin monotherapy 2550 mg daily |
| |
Glimeripide | | vs gliclazide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Charpentier (301F), | glimepiride 1-4mg od | gliclazide 80-320 mg/day (od or bid) | |
| |
Glimeripide | | vs glibenclamide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Draeger, 1996 | glimepiride 1 mg daily | 2.5 mg glibenclamide | type 2 diabetic patients stabilised on glibenclamide | Protocol 311, | glimepiride 1-8mg od | glibenclamide 1.75-14 mg/day
(od or bid) | |
| |
Glimeripide | | vs gliclazide or glibenclamide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Inukai, 2005 | glimepiride | gliclazide or glibenclamide | Japanese type 2 diabetic patients (HbA1C > or = 7.0%), maintained on a conventional SU |
| |
Glimeripide | | vs glimepiride bid | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Sonnenberg, 1997 | glimepirid e6mg od | glimepiride 3mg bid | |
| |
Glimeripide | | vs glipizide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Clark (301), 1997 | glimepiride 1-16 mg/day (od or bid) | glipizide 2.5-40 mg/day (od or bid) | |
| |
Glimeripide | | vs glyburide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Dills, 1996 | glimepiride 1-16mg od | non-micronized glyburide 1.25-20mg od | patients with non-insulin dependent diabetes |
| |
Glimeripide | diabetes type 2, in patients inadequately controlled on monotherapy | vs placebo (add on insulin) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Riddle, 1994 | Glimepiride (16 mg/day) plus insulin | insulin
plus placebo | obese
patients with type 2 diabetes insufficiently controlled
by full dosages of sulphonylureas (glimepiride titrated up to 8mg twice daily and with laboratory-monitored FPG of 10 to 16
mmol/L (180 to 300 mg/dl)) |
| |
Glimeripide | | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Any diabetes-related outcomes | no data | Diabetes-related death | no data | Peripheral vascular events | no data | macrovascular or microvascular events | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | microvascular events | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
Charpentier, 2001 | metformin and glimepiride | metformin | Type 2 diabetic patients aged 35-70 years inadequately controlled by metformin monotherapy 2550 mg daily |
| |
Glimeripide | | vs gliclazide or glibenclamide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Trial | Studied treatment | Control | Patients |
---|
Inukai, 2005 | glimepiride | gliclazide or glibenclamide | Japanese type 2 diabetic patients (HbA1C > or = 7.0%), maintained on a conventional SU |
| |
Glimeripide | diabetes type 2, in patients inadequately controlled on metformin | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Any diabetes-related outcomes | no data | Diabetes-related death | no data | Peripheral vascular events | no data | macrovascular or microvascular events | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | microvascular events | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
Charpentier, 2001 | metformin and glimepiride | metformin | Type 2 diabetic patients aged 35-70 years inadequately controlled by metformin monotherapy 2550 mg daily |
| |
Rosiglitazone | diabetes type 2, in patients inadequately controlled with insulin | vs | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
all cause death, MI, stroke | no data | cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | Heart failure | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
SB-712753/009 , | Rosiglitazone, metformin, and insulin | Insulin | patients with type 2 diabetes with insulin |
| |
Rosiglitazone | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
all cause death, MI, stroke | no data | cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | Heart failure | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
49653/136 , | Rosiglitazone | Placebo | patients with type 2 diabetes and chronic renal failure on Su, insulin, or both |
| |
Rosiglitazone | | vs placebo (add on insulin) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
all cause death, MI, stroke | no data | cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | Heart failure | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
BRL 49653/347 , | Rosiglitazone and insulin | Insulin | patients with type 2 diabetes poorly controlled on insulin | 49653/085 , | Rosiglitazone and insulin | Insulin | patients with type 2 diabetes | 49653/095 , | Rosiglitazone and insulin | Insulin | patients with type 2 diabetes poorly controlled on insulin |
| |