| Carotid artery stenting | carotid stenosis, in all type of stenosis | vs surgery | Stroke within 30 days by 55% suggested Cranial neuropathy within 30 days by 91% suggested Death or neurological complication within 30 days by 37% suggested Death or stroke or myocardial infarction by 35% suggested Stroke during follow up by 61% suggested long term restenosis by 182% suggested | | Endpoint | TE [95% CI] | p val | I2 | n | k | |
|---|
| Death or any stroke within 30 days | 1.29 [0.97 1.71] | p=1.00 | 0 | 3132 | 10 | Leicester (Naylor), WALLSTENT (Alberts), CAVATAS-CEA, Kentucky A (Brooks), SPACE, EVA-3S (Mas), BACASS (Hoffman), Kentucky B (Brooks), SAPPHIRE (yadav), TESCAS-C (Ling), | | Death or disabling stroke within 30 days | 1.16 [0.79 1.71] | p=1.00 | 0 | 2774 | 8 | Leicester (Naylor), CAVATAS-CEA, Kentucky A (Brooks), SPACE, EVA-3S (Mas), BACASS (Hoffman), Kentucky B (Brooks), SAPPHIRE (yadav), | | Death within 30 days | 0.85 [0.43 1.66] | p=1.00 | 0 | 2839 | 7 | CAVATAS-CEA, Kentucky A (Brooks), SPACE, EVA-3S (Mas), BACASS (Hoffman), SAPPHIRE (yadav), TESCAS-C (Ling), | | Stroke within 30 days | 1.55 [1.24 1.94] | p=0.04 | 0 | 6784 | 7 | CAVATAS-CEA, SPACE, EVA-3S (Mas), BACASS (Hoffman), SAPPHIRE (yadav), CREST, ICSS, | | Cranial neuropathy within 30 days | 0.09 [0.04 0.20] | p=0.04 | 0 | 3888 | 5 | CAVATAS-CEA, EVA-3S (Mas), BACASS (Hoffman), SAPPHIRE (yadav), CREST, | | Death or neurological complication within 30 days | 0.63 [0.45 0.89] | p=0.04 | 0 | 1386 | 4 | CAVATAS-CEA, EVA-3S (Mas), BACASS (Hoffman), SAPPHIRE (yadav), | | Death or stroke or myocardial infarction | 1.35 [1.02 1.77] | p=0.04 | 0 | 3099 | 5 | CAVATAS-CEA, EVA-3S (Mas), BACASS (Hoffman), SAPPHIRE (yadav), ICSS, | | Death or any stroke (during follow up) | 1.15 [0.86 1.54] | p=1.00 | 0 | 3483 | 7 | WALLSTENT (Alberts), CAVATAS-CEA, EVA-3S (Mas), BACASS (Hoffman), SAPPHIRE (yadav), TESCAS-C (Ling), ICSS, | | Death during follow up | 1.05 [0.62 1.79] | p=1.00 | 0 | 2593 | 4 | EVA-3S (Mas), BACASS (Hoffman), SAPPHIRE (yadav), ICSS, | | Stroke during follow up | 1.61 [1.11 2.33] | p=0.04 | 0 | 2593 | 4 | EVA-3S (Mas), BACASS (Hoffman), SAPPHIRE (yadav), ICSS, | | long term restenosis | 2.82 [1.62 4.93] | p=0.04 | 0 | 413 | 1 | CAVATAS-CEA, | | long term stroke | 1.23 [0.72 2.12] | p=1.00 | 0 | 504 | 1 | CAVATAS-CEA, | | long term fatal stroke | 2.52 [0.96 6.60] | p=1.00 | 0 | 504 | 1 | CAVATAS-CEA, | | non-perioperative ipsilateral stroke | 1.07 [0.72 1.60] | p=1.00 | 0 | 4604 | 4 | CAVATAS-CEA, SPACE, EVA-3S (Mas), CREST, |
| Trial | Studied treatment | Control | Patients |
|---|
| Leicester (Naylor), 1998 | Self-expanding Wallstent | surgery | patients with focal carotid territory symptoms and severe ICA stenosis (> 70%) | | WALLSTENT (Alberts), 2001 | Wallstent | | | | CAVATAS-CEA, 2001 | Pre-1994: PTA only after 1994: Wallstent, Streker, Palmaz | carotid endarterectomy | patients of any age with symptomatic or asymptomatic carotid artery stenosis suitable for surgery | | Kentucky A (Brooks), 2001 | Wallstent | surgery | patients presenting with cerebrovascular ischemia ipsilateral to carotid stenosis | | SPACE, 2000 | carotid-artery stenting (Carotid Wallstent; Precise; Acculink) | Carotid endarterectomy | patients with symptomatic carotid-artery stenosis within 180 days of transient ischaemic attack or moderate stroke (modified Rankin scale score of < or =3) | | EVA-3S (Mas), 2000 | various stent | endarterectomy | patients with a symptomatic carotid stenosis of at least 60% | | BACASS (Hoffman), 2006 | stent | CEA | patients with symptomatic carotid stenosis > 70% | | Kentucky B (Brooks), 2004 | Wallstent, Dynalink | carotid endarterectomy | patients with asymptomatic carotid stenosis of more than 80% were selected | | SAPPHIRE (yadav), 2004 | Smart or Precise (self-expanding nitinol stent)age/pj | surgery | patients with coexisting conditions that potentially increased the risk posed by endarterectomy and who had either a symptomatic carotid-artery stenosis of at least 50 percent of the luminal diameter or an asymptomatic stenosis of at least 80 percent | | TESCAS-C (Ling), 2006 | | | | | CREST, 2010 | carotid artery stenting (with distal-protection) | carotid endarterectomy | patients with both asymptomatic and symptomatic extracranial carotid stenosis | | ICSS, 2010 | carotid artery stenting | endarterectomy | patients with symptomatic carotid stenosis of greater than 50% within last six months |
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