Carfilzomib | multiple myeloma, in all type of patients | vs bortezomib | death (overall survival) by 21% suggested progression or death (progression free survival PFS) by 47% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
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death (overall survival) | 0.79 [0.65 0.96] | p=0.04 | 0 | 929 | 1 | ENDEAVOR, | progression or death (progression free survival PFS) | 0.53 [0.44 0.64] | p=0.04 | 0 | 929 | 1 | ENDEAVOR, |
Trial | Studied treatment | Control | Patients |
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ENDEAVOR, 2016 | carfilzomib with dexamethasone | bortezomib with dexamethasone | patients with relapsed or refractory multiplemyeloma who had one to three previous treatments |
| |
Carfilzomib | | vs bortezomid | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
death (overall survival) | no data | progression or death (progression free survival PFS) | no data |
Trial | Studied treatment | Control | Patients |
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ECOG-ACRIN, | | | | CLARION, | | | |
| |
Carfilzomib | | vs lenalidomide and dexamethasone alone | death (overall survival) by 21% suggested progression or death (progression free survival PFS) by 31% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
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death (overall survival) | 0.79 [0.63 0.99] | p=0.04 | 0 | -18 | 1 | ASPIRE, | progression or death (progression free survival PFS) | 0.69 [0.57 0.83] | p=0.04 | 0 | -18 | 1 | ASPIRE, |
Trial | Studied treatment | Control | Patients |
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ASPIRE, 2014 | carfilzomib with lenalidomide and dexamethasone | lenalidomide and dexamethasone alone | patients with relapsed multiple myeloma |
| |
Carfilzomib | | vs low-dose corticosteroids | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
death (overall survival) | 0.98 [0.76 1.25] | p=1.00 | 0 | 315 | 1 | FOCUS, | progression or death (progression free survival PFS) | no data |
Trial | Studied treatment | Control | Patients |
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FOCUS, 2017 | carfilzomib monotherapy | low-dose corticosteroids and optional cyclophosphamide | relapsed and refractory multiple myeloma (RRMM) |
| |