Vildagliptin | diabetes type 2, in all types of patients | vs | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
NCT00101673, | vildagliptin | | |
| |
Vildagliptin | | vs placebo (add on SU) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Garber, 2008 | vildagliptin (50 mg given once or twice daily) | placebo | patients with type 2 diabetes inadequately controlled with a sulphonylurea |
| |
Vildagliptin | | vs acarbose | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Pan, 2008 | vildagliptin (100 mg daily, given as 50 mg twice daily | acarbose (up to 300 mg daily, given as three equally divided doses | drug-naive patients with Type 2 diabetes |
| |
Vildagliptin | | vs voglibose | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
NCT00368134, | Vildagliptin 50 mg Bid | Voglibose 0.2 mg Tid | patients with type 2 diabetes | Iwamoto, 2010 | vildagliptin (50 mg bid, | voglibose (0.2 mg tid | Japanese patients with T2D who were inadequately controlled with diet and exercise |
| |
Vildagliptin | | vs MET | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
CLAF237A 23104, | | | |
| |
Vildagliptin | | vs metformin | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 0.58 [0.29 1.14] | p=1.00 | 0 | 771 | 1 | Schweizer, |
Trial | Studied treatment | Control | Patients |
---|
Schweizer, 2007 | vildagliptin 100mg | metformin up to 2000 mg daily | drug-naïve patients with Type 2 diabetes | Goke, 2008 | vildagliptin (100 mg daily) | metformin (2 000 mg daily). | drug-naïve patients with type 2 diabetes | Schweizer, 2009 | vildagliptin (100 mg daily | metformin (titrated to 1500 mg daily | drug-naïve patients with type 2 diabetes aged>or=65 years |
| |
Vildagliptin | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 1.81 [0.99 3.29] | p=1.00 | 0 | 1017 | 5 | Dejager [1], Pi-Sunyer, Pratley, Ristic, Scherbaum [2], |
Trial | Studied treatment | Control | Patients |
---|
Dejager [1], 2007 | vildagliptin 50 mg or 100 mg daily | placebo | drug-naïve patients with type 2 diabetes | Mimori, 2006 | vildagliptin 20 mg or 50 mg or 100 mg daily | placebo | | Pi-Sunyer, 2007 | vildagliptin 50 mg or 100 mg daily, imag | placebo | drug-naïve patients with type 2 diabetes | Pratley, 2006 | vildagliptin 25mg bid | placebo | | Ristic, 2005 | vildagliptin 25mg or 50mg or 100mg daily | placebo | | Scherbaum [2], 2008 | vildagliptin 50 mg qd | placebo | drug-naïve patients with type 2 diabetes and mild hyperglycaemia | Rosenstock, 2008 | vildagliptin (50 mg q.d.) | placebo | subjects with impaired glucose tolerance | Foley, 2011 | vildagliptin 100 mg | placebo | drug-naive patients with type 2 diabetes and mild hyperglycaemia | Kikuchi, 2009 | vildagliptin 50mg bid | placebo | Japanese patients with type 2 diabetes mellitus | NCT00351832, | vildagliptin 50mg qd, 50mg bid or 100mg qd | placebo | Patients With Type 2 Diabetes | Ahren, 2009 | vildagliptin (100 mg/d) | placebo | drug-naive patients with type 2 diabetes |
| |
Vildagliptin | | vs placebo (add on current therapy) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Lukashevich , 2011 | vildagliptin (50 mg qd) | placebo | patients with type 2 diabetes mellitus (T2DM) and moderate or severe renal impairment |
| |
Vildagliptin | | vs placebo (add on glimepiride) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Kikuchi, 2010 | vildagliptin 50mg twice-daily | placebo | Japanese patients with Type 2 diabetes mellitus |
| |
Vildagliptin | | vs placebo (add on insulin) | Adverse events leading to treatment discontinuation by 850% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 9.50 [1.19 75.97] | p=0.04 | 0 | 296 | 1 | Fonseca, |
Trial | Studied treatment | Control | Patients |
---|
Fonseca, 2007 | vildagliptin 100 mg daily (add-on to insulin therapy)y) | placebo (add-on to insulin therapy)y)mag | type 2 diabetes that was inadequately controlled by insulin | Fonseca , 2008 | vildagliptin added to insulin | | |
| |
Vildagliptin | | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 1.63 [0.50 5.36] | p=1.00 | 0 | 471 | 2 | Ahren, Bosi, |
Trial | Studied treatment | Control | Patients |
---|
Ahren, 2004 | vildagliptin 50 mg daily (add-on to metformin therapy)j | placebo (add-on to metformin therapy)mag | patients with type 2 diabetes | Bosi, 2007 | vildagliptin (50 or) 100 mg daily (add-on to metformin therapy)m | placebo (add-on to metformin therapy)mag | patients with type 2 diabetes inadequately controlled with metformin | Goodman, 2009 | ildagliptin 100 mg given in the morning, vildagliptin 100 mg given in the evening | placebo | patients inadequately controlled with metformin | Bosi, 2009 | vildagliptin plus high-dose metformin combination therapy (50 mg + 1000 mg twice daily), | high-dose metformin monotherapy (1000 mg twice daily). | treatment-naive patients with type 2 diabetes mellitus | NCT00728351, | Vildagliptin and Metformin (25/1000 mg Bid) | Metformin Monotherapy (1000 mg Bid) | Patients With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy | NCT00822211, | Vildagliptin 50 mg Bid or qd | placebo | Chinese Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy | NCT00494884 (Wollmer), | Vildagliptin 100 mg o.d. | placebo | Patients With Type 2 Diabetes Inadequately Controlled With Metformin | NCT00396071, | vildagliptin | placebo | Patients With Type 2 Diabetes Treated With Metformin |
| |
Vildagliptin | | vs placebo (on top pioglitazone) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 1.25 [0.33 4.74] | p=1.00 | 0 | 316 | 1 | Garber, |
Trial | Studied treatment | Control | Patients |
---|
Garber, 2007 | vildagliptin 50 or 100 mg daily (add-on to pioglitazone therapy) | placebo (add-on to pioglitazone therapy) | |
| |
Vildagliptin | | vs gliclazide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Foley, 2009 | monotherapy with vildagliptin 50 mg bid | gliclazide up to 320 mg/day | drug-naïve patients with type 2 diabetes |
| |
Vildagliptin | | vs gliclazide (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Filozof, 2009 | vildagliptin (50 mg twice daily | gliclazide (up to 320 mg/day | patients with Type 2 diabetes inadequately controlled with metformin |
| |
Vildagliptin | | vs glimepiride (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Matthews , 2010 | vildagliptin | glimepiride | patients with type 2 diabetes mellitus inadequately controlled (HbA1c 6.5-8.5%) by metformin monotherapy |
| |
Vildagliptin | | vs Sulfonylurea (add on to MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Ferrannini, 2009 | vildagliptin 50 mg twice daily | glimepiride titrated up to 6 mg/day | Patients inadequately controlled on metformin monotherapy (HbA(1c) 6.5-8.5%) |
| |
Vildagliptin | | vs TZD (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
GALIANT (Blonde), 2009 | vildagliptin 100 mg | TZD (agent and dose at the investigators discretion | patients inadequately controlled [haemoglobin A(1C) (HbA(1c)): 7-10%] on a stable dose of metformin (> or =1000 mg/day). |
| |
Vildagliptin | | vs pioglitazone | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock** (vilda vs pio), 2007 | vildagliptin 100 mg daily daily | pioglitazone 30 mg dailyaily | drug-naive patients with type 2 diabetes |
| |
Vildagliptin | | vs pioglitazone (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 0.95 [0.37 2.44] | p=1.00 | 0 | 576 | 1 | Bolli, |
Trial | Studied treatment | Control | Patients |
---|
Bolli, 2008 | vildagliptin 100 mg daily (add-on to metformin therapy) | pioglitazone 30 mg daily (add-on to metformin therapy)j | patients with type 2 diabetes inadequately controlled with metformin monotherapy |
| |
Vildagliptin | | vs placebo (add on TZD) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 0.47 [0.14 1.55] | p=1.00 | 0 | 314 | 1 | Rosenstock** (vilda + pio vs pio), |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock** (vilda + pio vs pio), 2007 | vildagliptin 50 mg or 100 mg daily plus 15 mg or 30 mg pioglitazone dailyi | pioglitazone 30 mg daily | drug-naive patients with type 2 diabetes |
| |
Vildagliptin | | vs rosiglitazone | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock* (vilda vs rosi), 2007 | vildagliptin 100 mg daily daily | rosiglitazone 8 mg once daily | drug-naïve patients with type 2 diabetes | Rosenstock, 2009 | vildagliptin (50 mg b.i.d | rosiglitazone (8 mg q.d., | drug-naïve type 2 diabetes mellitus patients |
| |
Alogliptin | diabetes type 2, in all types of patients | vs | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Seino, 2011 | | | | Seino, 2011 | | | | Bosi , 2011 | | | | Kaku, 2011 | | | | Rosenstock, 2010 | | | | Rosenstock, 2009 | | | | Pratley, 2009 | | | | Pratley, 2009 | | | | DeFronzo , 2008 | | | |
| |
Alogliptin | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 0.96 [0.81 1.13] | p=1.00 | 0 | 5380 | 1 | EXAMINE, | Cardiovascular death | 0.80 [0.60 1.06] | p=1.00 | 0 | 5380 | 1 | EXAMINE, | myocardial infarction (fatal and non fatal) | 1.07 [0.87 1.33] | p=1.00 | 0 | 5380 | 1 | EXAMINE, | stroke (fatal and non fatal) | 0.90 [0.54 1.49] | p=1.00 | 0 | 5380 | 1 | EXAMINE, | All cause death | 0.88 [0.70 1.10] | p=1.00 | 0 | 5380 | 1 | EXAMINE, | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
EXAMINE, 2011 | | | |
| |
Alogliptin | | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Nauck, 2009 | alogliptin 12.5 and 25 mg once daily | placebo | patients whose HbA(1c) levels were inadequately controlled on metformin alone |
| |
Linagliptin | diabetes type 2, in all types of patients | vs | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Forst, 2010 | Linagliptin (1, 5, or 10 mg taken once daily)
| placebo (on top Metformin )
| patients with type 2 diabetes mellitus who are not at goal with their HbA1c levels
|
| |
Linagliptin | | vs Metformin + sulfonylurea | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Owens, 0 | linagliptin
| combination of metformin and an SU
| type 2 diabetes mellitus with insufficient glycaemic control with metformin in combination with a sulphonylurea
|
| |
Linagliptin | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Del Prato, 0 | Linagliptin monotherapy
| placebo
| Type 2 Diabetic Patients With Insufficient Glycemic Control
|
| |
Linagliptin | | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Taskinen, 0 | linagliptin 5 mg once daily | placebo add on MET | patients with inadequately controlled type 2 diabetes for whom metformin therapy is inappropriate due to intolerability or contraindication |
| |
Linagliptin | | vs placebo (add on pioglitazone) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Gomis, 2011 | initial combination of 30 mg pioglitazone plus 5 mg linagliptin | pioglitazone plus placebo | patients with inadequately controlled type 2 diabetes |
| |
Linagliptin | | vs placebo (add on SU) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Lewin, 2010 | linagliptin 5 mg
| placebo (add-on to sulphonylurea)
| patients with type 2 diabetes and insufficient glycaemic control
|
| |
Linagliptin | | vs glimepiride | cardiovascular events by 54% suggested | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
Amputations | no data | nephropathy | no data | cardiovascular events | 0.46 [0.23 0.91] | p=0.04 | 0 | 1551 | 1 | CAROLINA, | Cardiovascular death | 1.00 [0.14 7.14] | p=1.00 | 0 | 1551 | 1 | CAROLINA, | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | retinopathy | no data | microvascular events | no data | hospitalisation for heart failure | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
CAROLINA, 2012 | linagliptin | glimepiride 1-4 mg QD | patients with type 2 diabetes at elevated cardiovascular risk receiving usual care |
| |
Linagliptin | | vs glimepiride (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data |
Trial | Studied treatment | Control | Patients |
---|
Gallwitz, 2012 | linagliptin (5 mg once daily) add-on therapy to preferably > 1500 mg metformin | glimepiride (1—4 mg) orally once daily add-on therapy to preferably > 1500 mg metformin | type 2 diabetes mellitus with insufficient glycaemic control with metformin |
| |
Saxagliptin | diabetes type 2, in all types of patients | vs | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Kawamori, 2012 | | | | Forst, 2011 | | | | Fonseca, 2012 | | | | Nowicki, 2011 | | | | Yang, 2011 | | | | Nowicki, 2011 | | | | Göke, 2010 | | | | Scheen , 2010 | | | | Stenlöf , 2010 | | | |
| |
Saxagliptin | | vs glyburide uptitration | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
CV181-040, | saxagliptin added to a submaximal sulphonylurea dose | uptitration of sulphonylurea monotherapy | patients with type 2 diabetes and inadequate glycaemic control with sulphonylurea monotherapy |
| |
Saxagliptin | | vs metformin up to 2000mg | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
CV181-085, | Saxagliptin in Combination With Metformin XR 1500 mg | Up-titrated Metformin XR to 2000 mg | Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control With Diet and Exercise and a Stable Dose of Metformin XR 1500 mg |
| |
Saxagliptin | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | 1.00 [0.89 1.12] | p=1.00 | 0 | 16492 | 1 | SAVOR-TIMI 53, | Cardiovascular death | 1.03 [0.86 1.22] | p=1.00 | 0 | 16492 | 1 | SAVOR-TIMI 53, | myocardial infarction (fatal and non fatal) | 0.95 [0.80 1.12] | p=1.00 | 0 | 16492 | 1 | SAVOR-TIMI 53, | stroke (fatal and non fatal) | 1.10 [0.88 1.39] | p=1.00 | 0 | 16492 | 1 | SAVOR-TIMI 53, | All cause death | 1.10 [0.96 1.27] | p=1.00 | 0 | 16492 | 1 | SAVOR-TIMI 53, | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
SAVOR-TIMI 53, 2013 | Saxagliptin 5 mg or 2.5 mg once daily
| Placebo | Patients With Type 2 Diabetes |
| |
Saxagliptin | | vs placebo (add on current treatment) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
saxgliptin, renal study, | saxagliptin | placebo added to patients’ current diabetes treatment | patients with moderate to severe renal impairment or end-stage renal disease |
| |
Saxagliptin | | vs placebo (add on insulin) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
CV181-057, | Saxagliptin, 5 mg | placebo (on top insulin) | Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control on Insulin Alone or on Insulin in Combination With Metformin |
| |
Saxagliptin | | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
DeFronzo, 2009 | saxagliptin (2.5, 5, or 10 mg once daily) | placebo | Patients With Inadequately Controlled
Type 2 Diabetes With Metformin Alone | Jadzinsky, 2009 | saxagliptin | placebo | treatment-naïve patients with type 2 diabetes (T2D) and inadequate glycaemic control | CV181-066, | Saxagliptin | placebo | Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control With Diet And Exercise And A Stable Dose Of Metformin ¡Ý1500 mg/Day | CV181-080, | 2.5 mg Saxagliptin, Twice Daily | placebo | Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin IR Alone |
| |
Saxagliptin | | vs placebo (add on TZD) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Hollander, | saxagliptin (2.5 or 5 mg) | placebo | patients with type 2 diabetes and inadequate control on thiazolidinedione alone |
| |
Saxagliptin | | vs placebo (monotherapy) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock, 2008 | saxagliptin 2.5, 5, 10, 20 or 40 mg once daily | placebo | drug-naive patients with T2DM and inadequate glycaemic control | CV181-011, | oral saxagliptin 2.5, 5, or 10 mg once daily | placebo | | CV181-038, | Saxagliptin monotherapy | placebo | type 2 diabetic subjects who are not controlled with diet and exercise | CV181-041, | Saxagliptin | placebo | Subjects With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise |
| |
Saxagliptin | | vs sitagliptin (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
saxagliptin vs sitagliptin, | saxagliptin 5 mg once daily add on metformin | sitagliptin 100 mg onece daily add on metformin | adults with type 2 diabetes who did not attain adequate glycemic control on metformin therapy alone |
| |
Saxagliptin | | vs glipizide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
saxagliptin, | saxagliptin | titrated glipizide plus metformin | adult patients with type 2 diabetes and inadequate glycemic control |
| |
Sitagliptin | diabetes type 2, in all types of patients | vs | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Stafford , 2011 | | | older adults with type 2 diabetes mellitus |
| |
Sitagliptin | | vs control (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Reasner, 2011 | sitagliptin/metformin 50/500 mg bid uptitrated over 4 weeks to achieve maximum doses of sitagliptin/metformin 50/1000 mg bid | metformin monotherapy | drug-naive patients with type 2 diabetes |
| |
Sitagliptin | | vs rosiglitazone (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Rigby , 2010 | sitagliptin phosphate, 100 mg daily | rosiglitazone maleate, 4 mg daily | type 2 diabetes mellitus inadequately controlled by metformin monotherapy |
| |
Sitagliptin | | vs voglibose | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Iwamoto , 2010 | sitagliptin 50 mg once daily monotherapy | voglibose 0.2 mg thrice daily before meals | Japanese patients with type 2 diabetes |
| |
Sitagliptin | | vs metformin+pio | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Derosa , 2010 | pioglitazone 30 mg plus sitagliptin 100 mg once a day | pioglitazone 15 mg plus metformin 850 mg twice a day | poorly controlled type 2 diabetes mellitus patients |
| |
Sitagliptin | | vs placebo | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 0.83 [0.50 1.38] | p=1.00 | 0 | 1781 | 6 | Aschner, Goldstein, Hanefeld, Nonaka, Raz, Scott* (sit vs pbo), |
Trial | Studied treatment | Control | Patients |
---|
Aschner, 2006 | sitagliptin 100 or 200 mg dailym | placebo | patients with type 2 diabetes | Goldstein, 2007 | sitagliptin 100 mg daily | placebo | | Hanefeld, 2007 | sitagliptin 25 mg or 50 mg or 100 mg dailyi | placebo | | Nonaka, 2008 | sitagliptin 100 mg daily monotherapy | placebo | Japanese patients with type 2 diabetes | Raz, 2006 | sitagliptin 100 mg (or 200 mg) daily | placebo | patients with type 2 diabetes mellitus and inadequate glycaemic control | Scott* (sit vs pbo), 2007 | sitagliptin 50 mg b.i.d | placebo | | Barzilai, 2011 | once-daily sitagliptin (100 or 50 mg, depending on renal function) | placebo | elderly patients with type 2 diabetes | Mohan , 2009 | sitagliptin 100mg once daily monotherapy | placebo | Chinese, Indian, and Korean patients with type 2 diabetes inadequately controlled by diet and exercise. | Chan, 2008 | sitagliptin | placebo | patients with type 2 diabetes and chronic renal insufficiency |
| |
Sitagliptin | | vs placebo (add on insulin+/-MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Vilsbøll, 2010 | once-daily sitagliptin 100 mg | placebo | patients with type 2 diabetes inadequately controlled on long-acting, intermediate-acting or premixed insulin |
| |
Sitagliptin | | vs placebo (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 1.02 [0.61 1.68] | p=1.00 | 0 | 2058 | 3 | Charbonnel, Nauck, Scott** (sit vs pbo on top met), |
Trial | Studied treatment | Control | Patients |
---|
Charbonnel, 2006 | sitagliptin 100 mg daily (add-on to metformin therapy)j | placebo (add-on tometformin therapy); | | Nauck, 2007 | sitagliptin 100 mg daily (add-on to metformin therapy)j | placebo (add-on to metformin therapy); | | Scott** (sit vs pbo on top met), 2007 | sitagliptin 100 mg daily (add-on to metformin therapy)j | placebo (add-on to metformin therapy). | patients with type 2 diabetes who were inadequately on mET monotherapy | raz, 2008 | sitagliptin 100 mg once daily | placebo | patients with type 2 diabetes |
| |
Sitagliptin | | vs placebo (add on PIO) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock , 2006 | sitagliptin 100 mg once daily | placebo | patients with type 2 diabetes and inadequate glycemic control |
| |
Sitagliptin | | vs placebo (on top PIO) | Adverse events leading to treatment discontinuation by 459% adverse event | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 5.59 [1.22 25.62] | p=0.04 | 0 | 353 | 1 | Rosenstock (sit on top pio vs pbo), |
Trial | Studied treatment | Control | Patients |
---|
Rosenstock (sit on top pio vs pbo), 2006 | sitagliptin 100 mg daily (add-on to pioglitazone therapy)sl˜ðõØ | placebo (add-on to pioglitazone therapy); | |
| |
Sitagliptin | | vs placebo (on-top glimepiride+/- metformine) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | 2.74 [0.28 26.77] | p=1.00 | 0 | 222 | 1 | Hermansen, |
Trial | Studied treatment | Control | Patients |
---|
Hermansen, 2007 | sitagliptin 100 mg daily (add-on to ongoing stable doses of glimepiride, alone or in combination with metformin)ocumen | placebo (add-on to ongoing stable doses of glimepiride, alone or in combination with metformin); | |
| |
Sitagliptin | | vs glimepiride (add on MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Arechavaleta, 2011 | sitagliptin 100 mg daily | glimepiride (starting dose 1 mg/day and up-titrated, based upon patients self-monitoring of blood glucose results, to a maximum dose of up to 6 mg/day) | patients with type 2 diabetes inadequately controlled on metformin monotherapy |
| |
Sitagliptin | | vs Sulphonylurea (on top MET) | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Al Sifri, 2011 | sitagliptin 100 mg qd | prestudy sulphonylurea | Muslim patients with type 2 diabetes who were treated with a stable dose of a sulphonylurea with or without metformin for at least 3 months |
| |
Sitagliptin | | vs metformin | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Goldstein (sit vs met), 2007 | sitagliptin 100 dailyily | metformin 1000 mg or 2000 mg daily;imag | | Goldstein (sit+met vs met), 2007 | sitagliptin 50 mg daily plus metformin 1000 or 2000 mg dailyç$4 | metformin 1000 or 2000 mg daily | | Aschner, 2010 | once-daily sitagliptin 100 mg | twice-daily metformin 1000 mg | treatment-naïve patients with type 2 diabetes |
| |
Sitagliptin | | vs glipizide | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Scott* (sit vs glipi), 2007 | sitagliptin 50mg bid | glipizide 5mg to 20 mg dailyitm | patients with type 2 diabetes who have inadequate glycaemic control on diet and exercise |
| |
Sitagliptin | | vs pioglitazone | all NS | Endpoint | TE [95% CI] | p val | I2 | n | k | |
---|
cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | All cause death | no data | Adverse events leading to treatment discontinuation | no data |
Trial | Studied treatment | Control | Patients |
---|
Pérez-Monteverde, 2011 | sitagliptin100 mg qd | pioglitazone 15 mg qd, up-titrated to 30 mg after 6 weeks | drug-naïve patients with type 2 diabetes |
| |