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transcatheter aortic-valve implantation (TAVI)

TAVI

aortic stenosis, in all type of patients

vs standard therapy

stroke or TIA by 138% suggested

All cause death by 38% suggested

Endpoint	TE [95% CI]	p val	I2	n	k
Death from any cause or major stroke	0.66 [0.43 1.01]	p=1.00	0	358	1	PARTNER,
major stroke	2.00 [0.79 5.08]	p=1.00	0	358	1	PARTNER,
stroke or TIA	2.38 [1.01 5.58]	p=0.04	0	358	1	PARTNER,
All cause death	0.62 [0.40 0.95]	p=0.04	0	358	1	PARTNER,

Trial	Studied treatment	Control	Patients
PARTNER, 2010	transcatheter aortic-valve implantation (TAVI)with Edwards SAPIEN Transcatheter Heart Valve	standard therapy	patients with severe aortic stenosis considered not to be suitable candidates for surgery

TAVI

vs surgical valve replacement

Endpoint	TE [95% CI]	p val	I2	n	k
Death from any cause or major stroke	no data
major stroke	no data
stroke or TIA	no data
All cause death	no data

Trial	Studied treatment	Control	Patients
PARTNER cohort A, 2011	percutaneous valve implantation (Sapien device)	surgical valve replacement	high risk, symptomatic patients with severe aortic stenosis

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