Mechanism

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ACAT inhibition

Pactimibe

cardiovascular prevention, in all type of patients

Endpoint	TE [95% CI]	p val	I2	n	k
Coronary revascularization	no data
Carotid revascularization	no data
cardiovascular events including revascularization	no data
cardiovascular events	no data
Cardiovascular death	no data
stroke (fatal and non fatal)	no data
Coronary event	no data
Coronary death	no data
Non fatal MI	no data
All cause death	no data
Non fatal stroke	no data

Trial	Studied treatment	Control	Patients
CAPTIVATE, 2009	pactimibe 100mg daily	placebo	patients with familial hypercholesterolemia and carotid atherosclerosis
ACTIVATE, 2006	pactimibe 100 mg daily	placebo	patients with angiographicallydocumented coronary disease

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