heart failure | All results are NS for efficacy inferior to placebo in terms of Total mortality in PROMISE, 1991 inferior to placebo in terms of Sudden death in PROMISE, 1991 inferior to placebo in terms of Cardiac death in PROMISE, 1991 inferior to placebo in terms of Vertigo in PROMISE, 1991 | meta-analysis | | Trial | control | p<0.05 | harm | NS |
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PROMISE, 1991 | vs placebo | | Total mortality 1.24 [1.02; 1.51] Sudden death 1.57 [1.14; 2.17] Cardiac death 1.30 [1.06; 1.60] Vertigo 1.90 [1.40; 2.57] | Myocardial infarction (fatal & non fatal) 5.64 [0.68; 46.66] Worsening heart failure (requiring intervention) 1.88 [0.65; 5.46] Transplantation 0.63 [0.11; 3.73] Arrhythmia 1.22 [0.95; 1.56] | MMTG, 1989 | vs placebo | | | Total mortality 2.33 [0.94; 5.80] Myocardial infarction (fatal & non fatal) ∞ [NaN; ∞] Cardiac death 1.87 [0.72; 4.80] Worsening heart failure (requiring intervention) 0.87 [0.57; 1.34] Arrhythmia 1.87 [0.91; 3.81] Vertigo 2.05 [0.74; 5.72] |
Trial | Treatments | Patients | Method |
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PROMISE, 1991 | Milrinone 40mg/d (n=561) vs. placebo (n=527) | NYHA III,IV | double blind Parallel groups Sample size: 561/527 Primary endpoint: Total mortality FU duration: 20 months | MMTG, 1989 | Milrinone <40mg/d (n=119) vs. placebo (n=111) | NYHA II-IV | double blind Parallel groups Sample size: 119/111 Primary endpoint: none FU duration: 3 months |
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