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Description Results

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All pathologies
hypertension

all type of patient 13 - 5
elderly (60 years and more) 9 - 5
uncomplicated hypertension 685 - 5

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pathology

Benefit (demonstrated or suggested) and harm

hypertension

All results are NS for efficacy

Trial	control	p<0.05	harm	NS
ELSA, 2002	vs atenolol
SHELL, 2003	vs atenolol

Trial

Treatments

Patients

Method

ELSA, 2002

Lacidipine (n=1177)

vs.

atenolol (n=1157)

patients with hypertension

Double blind

Parallel groups

Sample size: 1177/1157

Primary endpoint: intima-media thicknesses

FU duration: 4·0y

SHELL, 2003

lacidipine 4 mg/d (n=-9)

vs.

chlorthalidone 12.5 mg/d (n=-9)

elderly patients with isolated systolic hypertension > or = 60 years

Sample size: -9/-9

Primary endpoint: cardiovascular and cerebrovascular events

FU duration: 3·6?y

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