Trandolapril angiotensin-Converting Enzyme Inhibitors

Description Results

Trandolapril 1 mg daily initial dose, up to 4 mg daily (n=876)

vs.

placebo (n=873)

Double blind

Parallel groups

Sample size: 876/873

Primary endpoint: death from any cause

FU duration: 3 y

Trandolapril 1 mg daily initial dose, up to 4 mg daily (n=876)

vs.

placebo (n=873)

Double blind

Parallel groups

Sample size: 876/873

Primary endpoint: death from any cause

FU duration: 3 y

trandolapril titrated up to 4mg/d (n=144)

vs.

placebo (n=148)

double blind

Sample size: 144/148

Primary endpoint: Exercise tolerance

FU duration: 16 weeks

nouveau diabète 0.83 [0.73; 0.96]

Crit principaux 0.97 [0.90; 1.05]

EUROPA endpoint 0.97 [0.84; 1.11]

PEACE endpoint 0.99 [0.92; 1.06]

Mortalité totale 0.89 [0.77; 1.03]

Ev. coronariens 0.97 [0.90; 1.05]

Décès cardiovasculaires 0.95 [0.76; 1.19]

revascularisation 0.92 [0.78; 1.07]

Infarctus non mortel 1.00 [0.84; 1.20]

AVC mortels et non mortels 0.77 [0.56; 1.04]

Ev. cardiovasculaires 0.97 [0.84; 1.12]

HOPE endpoint 0.94 [0.82; 1.07]

Trandolapril at a target dose of 4 mg per day (n=4158)

vs.

Placebo (n=4132)

In February 2002, given the increasing evidence of the benefit of ACE inhibitors or angiotensinreceptor blockers in patients with diabetes mellitus and renal disease, the investigators were adviced to substitute open-label ACE inhibitors for the masked study treatment in patients with diabetes and either overt proteinuria or hypertension and microalbuminuria.

Double blind

Parallel groups

Sample size: 4158/4132

Primary endpoint: death from cardiovascular causes, nonfatal myocardial infarction, or coronary revascularization

FU duration: median 4.8 y