new version V2017

Evolocumab PCSK9 Inhibitors
Description Results

Repatha - AMG-145 - evolocumab - AMG 145      

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

cardiovascular prevention

MENDEl 2evolocumab - NCT01763827
GAUSS 2evolocumabezetimibe aloneNegative NCT01763905
LAPLACE-TIMI 57evolocumabplacebo (on top statins) - NCT01380730
RUTHERFORD-1evolocumabplacebo (on top statins)NegativeNCT01375751
Mendel 1, 2012evolocumab - NCT01375777
GAUSS 1, 2012evolocumabplaceboNegativeNCT01375764
YUKAWA-1, 2014evolocumab -
DESCARTES, 2014evolocumabplacebo (on top statins)NegativeNCT01516879
LAPLACE 2, 2014evolocumabplacebo (on top statins)NegativeNCT01763866
RUTHERFORD-2, 2015evolocumabplacebo (on top statins)NegativeNCT01763918
FOURIER, 2017evolocumabplacebo (on top statins) Low risk of bias ConclusiveNCT01764633



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