new version V2017

Bevacizumab angiogenesis inhibitors

Avastin      

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

advanced breast cancer (metastatic)

AVF2119g (Miller) cape, 2005bevacizumab + capecitabinecapecitabine Risk of bias Suggesting
Burstein, 2005bevacizumab + methotrexatemethotrexateNegative
E2100 (Miller), 2007bevacizumab + taxanestaxanes Risk of bias SuggestingNCT00028990
RIBBON-I (Robert) on top capecitabine, 2009bevacizumab + capecitabinecapecitabineSuggesting
RIBBON-2 (Brufsky), 2009bevacizumav + CTCT aloneSuggesting
AVADO (Miles) 15mg , 2009bevacizumab + docetaxeldocetaxelSuggesting
RIBBON-I (Robert) on top Tax or anthra, 2009bevacizumab + taxanestaxanesSuggesting
AVADO (Miles) 7.5mg, 2010bevacizumab + docetaxeldocetaxelNegative
Martin bevacizumab, 2011bevacizumab + paclitaxelpaclitaxelNegative

lung cancer (metastatic)

Johnson, 2004bevacizumabplatinum based CT -
Sandler, 2006bevacizumabplatinum based CT -
Herbst, 2007bevacizumabplatinum based CT -
Nishio, 2009bevacizumabplatinum based CT -
Reck, 2010bevacizumab -
Herbst, 2011bevacizumab + erlotiniberlotinib alone -

renal-cell carcinoma (advanced)

Yang, 2003bevacizumabplacebo Exploratory -
AVOREN, 2007bevacizumab plus interferon alfainterferon alphaSuggesting
CALGB 90206, 2010bevacizumab plus interferon alfainterferon alphaSuggesting