new version V2017

aromatase inhibitors

Aminoglutethimide - Anastrozole - Exemestane - Fadrozole - Formestane - Letrozole      

TrialStudied treatmentControl treatmentpatientsROBResultNCT

advanced breast cancer (metastatic)

aminoglutethimide
Powles, 1984combination of hormone therapiestamoxifenNegative
Ingle, 1986aminoglutethimide + tamoxifentamoxifenNegative
Canney, 1988aminoglutethimidemedroxyprogesterone acetateSuggesting
Alonso-Munoz, 1988aminoglutethimidetamoxifenNegative
Lundgren, 1989aminoglutethimidemegestrol acetateNegative
Garcia-Giralt, 1992aminoglutethimidemedroxyprogesterone acetateNegative
Mercer, 1993aminoglutethimidehydrocortisoneNegative
Samonis, 1994aminoglutethimidemedroxyprogesterone acetateNegative
Gale, 1994aminoglutethimidetamoxifenNegative
Russell, 1997aminoglutethimidemegestrol acetateNegative
anastrozole
Buzdar a, 1996anastrozolemegestrol acetateNegative
TARGET (Bonneterre), 2001anastrozoletamoxifenSuggesting
Mauriac, 2003anastrozolefulvestrantNegative
Milla-Santos, 2003anastrozoletamoxifenNegative
exemestane
Kaufmann, 2000exemestanemegestrol acetateNegative
Paridaens, 2003exemestanetamoxifenNegative
Chia, 2008exemestanefulvestrantNegative
fadrozole
Buzdar b, 1996fadrozolemegestrol acetateNegative
Buzdar c, 1996fadrozolemegestrol acetateNegative
Thuerlimann, 1996fadrozoletamoxifenNegative
Falkson, 1996fadrozoletamoxifenNegative
Bezwoda, 1998fadrozolemegestrol acetateNegative
formestane
Perez Carrion, 1994formestanetamoxifenNegative
Kleeberg, 1997formestaneanastrozoleNegative
Thuerlimann, 1997formestanemegestrol acetateNegative
Freue, 2000formestanemegestrol acetateSuggesting
letrozole
Gershanovich, 1998letrozoleaminoglutethimideNegative
Dombernowsky, 1998letrozolemegestrol acetateNegative
Buzdar, 2001letrozolemegestrol acetateSuggesting
Mourisden, 2001letrozoletamoxifenNegative
Rose, 2003letrozoleanastrozoleNegative
Tominaga, 2003letrozolefadrozoleNegative
Goss, 2007letrozoleatamestane + toremifeneNegative