new version V2017
glucose lowering for cardiovascular prevention
Trial | Studied treatment | Control treatment | patients | ROB | Result | NCT |
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|
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ALEPREVENT | aleglitazar | placebo | | | - | EUDRACT201200067116 |
ALECARDIO, 2014 | aleglitazar | placebo | | Exploratory | Negative | NCT01042769 |
|
EXAMINE, 2013 | alogliptin | placebo | | Exploratory | Negative | NCT00968708 |
|
CANVAS, 2017 | canagliflozin | placebo | | Exploratory | Conclusive | NCT01032629 |
|
DECLARE TIMI 58, 2018 | dapagliflozin | placebo | | Exploratory | - | NCT01730534 |
|
EMPA-REG OUTCOME, 2015 | empagliflozin | placebo | | Low risk of bias | Conclusive | NCT01131676 |
|
VERTIS CV ongoing | ertugliflozin | placebo | | | - | NCT01986881 |
|
EXSCEL, 2017 | exenatide | placebo | | Low risk of bias | Conclusive | NCT01144338 |
|
ORIGINE, 2012 | insulin glargine | control | | | Negative | NCT00069784 |
|
CAROLINA, 2012 | linagliptin | glimepiride | | Exploratory | Suggesting | NCT01243424 |
CARMELINA ongoing | linagliptin | placebo | | | - | NCT01897532 |
|
LEADER, 2016 | liraglutide | placebo | | Exploratory | Conclusive | NCT01179048 |
|
ELIXA | lixisenatide | placebo | | Exploratory | Negative | NCT01147250 |
|
PROACTIVE | pioglitazone | placebo | | | - | NCT00174993 |
IRIS, 2016 | pioglitazone | placebo | | | - | NCT00091949 |
|
SAVOR TIMI, 2013 | saxagliptin | placebo | | Exploratory | Negative | NCT01107886 |
|
SUSTAIN 6, 2016 | semaglutide | placebo | | Exploratory | Conclusive | NCT01720446 |
|
TECOS, 2015 | sitagliptin | placebo | | Exploratory | Negative | NCT00790205 |