new version V2017

insulin secretagogues - DPP-4 inhibitors
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TrialStudied treatmentControl treatmentpatientsROBResultNCT

diabetes type 2

alogliptin
DeFronzo , 2008alogliptin - NCT00286455
Rosenstock, 2009alogliptin - NCT00286429
Pratley, 2009alogliptin - NCT00286494
Pratley, 2009alogliptin - NCT00286468
Nauck, 2009alogliptinplacebo (add on MET) Exploratory Negative NCT00286442
Rosenstock, 2010alogliptin - NCT00395512
Seino, 2011alogliptin - NCT01263509
Seino, 2011alogliptin -
Bosi , 2011alogliptin - NCT00432276
Kaku, 2011alogliptin -
EXAMINE, 2011alogliptinplaceboNegativeNCT00968708
linagliptin
OwenslinagliptinMetformin + sulfonylurea - NCT00602472
Del Pratolinagliptinplacebo - NCT00621140
Taskinenlinagliptinplacebo (add on MET) - NCT00601250
Forst, 2010linagliptin - NCT00309608
Lewin, 2010linagliptinplacebo (add on SU) - NCT00819091
Gomis, 2011linagliptinplacebo (add on pioglitazone) - NCT00641043
CAROLINA, 2012linagliptinglimepiride Exploratory SuggestingNCT01243424
Gallwitz, 2012linagliptinglimepiride (add on MET) - NCT00622284
linagliptin 1218.62 ongoing linagliptin low doselinagliptin - NCT01012037
linagliptine 1218.50 ongoing linagliptinplacebo - NCT00740051
linagliptin1218.5 ongoing linagliptinplacebo - NCT00328172
linagliptin 1218.46 ongoing linagliptinplacebo - NCT00798161
linagliptin 1218.65 ongoing linagliptinplacebo (add on MET) - NCT01215097
linagliptin 1218.61 ongoing linagliptinplacebo (add on MET+TZD) - NCT00996658
pioglitazone
linagliptin 1264.3 ongoing linagliptin + pioglitazonepioglitazone - NCT01183013
saxagliptin
saxagliptinsaxagliptinglipizide -
CV181-040saxagliptin + glyburideglyburide uptitration - NCT00313313
CV181-085saxagliptin plus metformin XR 1500mgmetformin up to 2000mg - NCT00918138
saxgliptin, renal studysaxagliptinplacebo (add on current treatment) -
CV181-057saxagliptinplacebo (add on insulin) - NCT00757588
CV181-066saxagliptinplacebo (add on MET) - NCT00683657
CV181-080saxagliptinplacebo (add on MET) - NCT00885378
Hollandersaxagliptinplacebo (add on TZD) - NCT00295633
CV181-011saxagliptinplacebo (monotherapy) - NCT00121641
CV181-038saxagliptinplacebo (monotherapy) - NCT00316082
CV181-041saxagliptinplacebo (monotherapy) - NCT00374907
saxagliptin vs sitagliptinsaxagliptinsitagliptin (add on MET) -
Rosenstock, 2008saxagliptinplacebo (monotherapy) - NCT00950599
DeFronzo, 2009saxagliptinplacebo (add on MET)Negative NCT00121667
Jadzinsky, 2009saxagliptinplacebo (add on MET) - NCT00327015
Göke, 2010saxagliptin -
Scheen , 2010saxagliptin -
Stenlöf , 2010Saxagliptin -
Forst, 2011Saxagliptin -
Nowicki, 2011saxagliptin - NCT00614939
Yang, 2011saxagliptin - NCT00661362
Nowicki, 2011saxagliptin - NCT00614939
Kawamori, 2012saxagliptin - NCT00654381
Fonseca, 2012saxagliptin - NCT00960076
SAVOR-TIMI 53, 2013saxagliptinplaceboNegative NCT01107886
sitagliptin
Aschner, 2006sitagliptin monotherapyplaceboNegativeNCT00087516
Raz, 2006sitagliptin monotherapyplaceboNegative
Charbonnel, 2006sitagliptinplacebo (add on MET)NegativeNCT0086515
Rosenstock , 2006sitagliptinplacebo (add on PIO) - NCT00086502
Rosenstock (sit on top pio vs pbo), 2006sitagliptinplacebo (on top PIO)SuggestingNCT00086502
Scott* (sit vs glipi), 2007sitagliptin 50mg bid monotherapyglipizide -
Goldstein (sit vs met), 2007sitagliptinmetformin -
Goldstein (sit+met vs met), 2007sitagliptinmetformin -
Goldstein, 2007sitagliptinplaceboNegativeNCT00103857
Hanefeld, 2007sitagliptinplaceboNegative
Scott* (sit vs pbo), 2007sitagliptin 50mg bid monotherapyplaceboNegative
Nauck, 2007sitagliptinplacebo (add on MET)NegativeNCT00094770
Scott** (sit vs pbo on top met), 2007sitagliptinplacebo (add on MET)Negative
Hermansen, 2007sitagliptinplacebo (on-top glimepiride+/- metformine)Negative
Nonaka, 2008sitagliptin monotherapyplaceboNegativeNCT00371007
Chan, 2008sitagliptin monotherapyplacebo -
raz, 2008sitagliptinplacebo (add on MET) - NCT00337610
Mohan , 2009sitagliptin monotherapyplacebo -
Aschner, 2010sitagliptin monotherapymetformin - NCT00449930
Derosa , 2010sitagliptin+piometformin+pio -
Vilsbøll, 2010sitagliptinplacebo (add on insulin+/-MET) - NCT00395343
Rigby , 2010sitagliptinrosiglitazone (add on MET) -
Iwamoto , 2010sitagliptin monotherapyvoglibose -
Stafford , 2011sitagliptin - NCT00451113
Reasner, 2011sitagliptincontrol (add on MET) - NCT00482729)
Arechavaleta, 2011sitagliptinglimepiride (add on MET) - NCT00701090
Pérez-Monteverde, 2011sitagliptinpioglitazone - NCT00541450
Barzilai, 2011sitagliptin monotherapyplacebo - NCT00305604
Al Sifri, 2011sitagliptinSulphonylurea (on top MET) -
vildagliptin
NCT00101673vildagliptin - NCT00101673
CLAF237A 23104vildagliptin + METMET - NCT00396357
NCT00351832vildagliptinplacebo - NCT00351832
NCT00728351vildagliptinplacebo (add on MET) - NCT00728351
NCT00822211vildagliptinplacebo (add on MET) - NCT00822211
NCT00494884 (Wollmer)vildagliptinplacebo (add on MET) - NCT00494884
NCT00396071vildagliptinplacebo (add on MET) - NCT00396071
NCT00368134vildagliptinvoglibose - NCT00368134
Ahren, 2004vildagliptinplacebo (add on MET)Negative
Ristic, 2005vildagliptin monotherapyplaceboNegative
Mimori, 2006vildagliptinplacebo -
Pratley, 2006vildagliptin monotherapyplaceboNegative
Schweizer, 2007vildagliptinmetforminNegativeNCT00099866
Rosenstock** (vilda vs pio), 2007vildagliptin monotherapypioglitazone - NCT00101803
Dejager [1], 2007vildagliptin monotherapyplaceboNegativeNCT00099905
Pi-Sunyer, 2007vildagliptin monotherapyplaceboSuggestingNCT00120536
Fonseca, 2007vildagliptinplacebo (add on insulin)SuggestingNCT00099931
Bosi, 2007vildagliptinplacebo (add on MET)NegativeNCT00099892
Rosenstock** (vilda + pio vs pio), 2007vildagliptinplacebo (add on TZD)NegativeNCT00101803
Garber, 2007vildagliptinplacebo (on top pioglitazone)NegativeNCT00099853
Rosenstock* (vilda vs rosi), 2007vildagliptinrosiglitazone - NCT00099918
Pan, 2008vildagliptin monotherapyacarbose - NCT00110240
Goke, 2008vildagliptinmetformin -
Bolli, 2008vildagliptinpioglitazone (add on MET)NegativeNCT00237237
Scherbaum [2], 2008vildagliptinplaceboNegativeNCT00101712
Rosenstock, 2008vildagliptinplacebo - NCT00237250
Fonseca , 2008vildagliptinplacebo (add on insulin) -
Garber, 2008vildagliptinplacebo (add on SU) - NCT00099944
Foley, 2009vildagliptin monotherapygliclazide - NCT00102388
Filozof, 2009vildagliptingliclazide (add on MET) - NCT00102466
Schweizer, 2009vildagliptinmetformin - NCT00246619
Kikuchi, 2009vildagliptin monotherapyplacebo -
Ahren, 2009vildagliptin monotherapyplacebo - NCT00390520
Goodman, 2009vildagliptinplacebo (add on MET) Exploratory Negative
Bosi, 2009vildagliptinplacebo (add on MET) - NCT00382096
Rosenstock, 2009vildagliptinrosiglitazone - NCT00138619
Ferrannini, 2009vildagliptinSulfonylurea (add on to MET) Exploratory SuggestingNCT00106340
GALIANT (Blonde), 2009vildagliptinTZD (add on MET) - NCT00396227
Matthews , 2010vildagliptinglimepiride (add on MET) -
Kikuchi, 2010vildagliptinplacebo (add on glimepiride) - NCT00325117
Iwamoto, 2010vildagliptinvoglibose - NA
Foley, 2011vildagliptin monotherapyplacebo - NCT00260156
Lukashevich , 2011vildagliptinplacebo (add on current therapy) - NA



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