Clinical trials of lifestyle intervention

Trial	Studied treatment	Control treatment	patients	ROB	Result	NCT
cardiovascular prevention
diet
Rose, 1965	diet	usual diet		Exploratory	Negative
MRC low fat, 1965	diet	usual diet		Risk of bias	Negative
Woodhill, 1966	diet	usual diet		Low risk of bias	Negative
Oslo Diet Heart Study (Leren), 1966	diet	usual diet		Risk of bias	Suggesting
MRC Soya, 1968	diet	usual diet		Risk of bias	Negative
Veterans Ad. (Dayton), 1969	diet	usual diet		Low risk of bias	Suggesting
Los Angeles VA (Dayton), 1969	diet	usual diet		Risk of bias	-
Minnesota coronary survey (Frantz), 1975	diet	usual diet		Exploratory	Negative
Kallio, 1979	diet	usual diet		Exploratory	-
Hjermann, 1981	diet	usual diet		Risk of bias	-
MRFIT, 1982	diet	usual diet		Risk of bias	-
Finnish Mental Hospital (Miettinen), 1985	diet	usual diet	primary prevention	Exploratory	-
Göteborg (Wilhelmsen), 1986	diet	usual diet		Low risk of bias	Negative
Goteborg, 1986	diet	usual diet		Risk of bias	-
Ornish, 1990	diet	usual diet		Exploratory	Negative
Singh, 1992	diet	usual diet		Risk of bias	-
STARS (St Thomas, diet), 1992	diet	usual diet		Exploratory	Negative
Black, 1994	diet	usual diet		Risk of bias	Negative
WHI low fat, 2005	diet	usual diet		Exploratory	Negative	NCT00000611
Tuttle, 2008	low fat diet	mediterranean-style diet		Risk of bias	-

lifestyle intervention Description Results