new version V2017

Pravastatin cholesterol lowering intervention
Description Results

Lipostat - Pravasin - Pravacol - Selektine - Elisor - Pravachol - Mevalotin - Prareduct - Lipemol - CS514 - CS 514 - CS-514 - Bristacol - Vasten - SQ31000 - SQ 31000 - SQ-31000 - RMS431 - RMS 431 - RMS-431 - Liplat - Eptastatin - Pravastatin      

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute coronary syndrome

LAMIL, 1997pravastatinplaceboacute coronary syndrome Exploratory Negative
RECIFE, 1999pravastatinplaceboacute coronary syndrome Exploratory Negative
L-CAD, 2000pravastatinusual careacute coronary syndrome Exploratory Suggesting
PAIS, 2001pravastatinplaceboacute coronary syndrome Exploratory Negative
PTT, 2002pravastatinusual careacute coronary syndrome Exploratory Suggesting
PACT, 2004pravastatinplaceboacute coronary syndrome Low risk of bias Suggesting

atrial fibrillation

Tveit, 2004pravastatincontrol Exploratory Negative

cardiovascular prevention

PMSG, 1993pravastatinplaceboprimary prevention Exploratory Negative
KAPS, 1995pravastatinplaceboprimary prevention Exploratory Negative
PLAC I (elderly sub group), 1995Pravastatinplaceboelderly Exploratory Negative
PLAC I, 1995pravastatinplacebosecondary prevention Exploratory Suggesting
PLAC II, 1995pravastatinplacebosecondary prevention Exploratory Negative
REGRESS, 1995pravastatinplacebosecondary prevention Exploratory Suggesting
WOSCOPS, 1995pravastatinplaceboprimary prevention Low risk of bias Conclusive
REGRESS (elderly subgroup), 1995Pravastatinplaceboelderly Exploratory Negative
WOSCOPS (diabetic sub group), 1996pravastatinplacebodiabetic patients Exploratory -
CAIUS, 1996pravastatinplaceboprimary prevention Exploratory Negative
CARE, 1996pravastatinplacebosecondary prevention Low risk of bias Conclusive
LAMIL, 1997pravastatinplaceboacute coronary syndrome Exploratory Negative
LIPID (diabetic sub group), 1998pravastatinplacebodiabetic patients Exploratory Negative
CARE (diabetic sub group), 1998pravastatinplacebodiabetic patients Exploratory Suggesting
CARE (elderly subgroup), 1998Pravastatinplaceboelderly Exploratory Suggesting
LIPID, 1998pravastatinplacebosecondary prevention Low risk of bias Conclusive
RECIFE, 1999pravastatinplaceboacute coronary syndrome Exploratory Negative
KLIS, 2000pravastatinusual careprimary prevention Risk of bias -
GISSI P (diabetic sub group), 2000pravastatinusual carediabetic patients Exploratory -
L-CAD, 2000pravastatinusual careacute coronary syndrome Exploratory Suggesting
GISSI Prevenzione, 2000pravastatinusual caresecondary prevention Risk of bias Negative
LIPID (elderly sub group), 2001Pravastatinplaceboelderly Exploratory Suggesting
PAIS, 2001pravastatinplaceboacute coronary syndrome Exploratory Negative
FAST Fukuoka pravastatin, 2002pravastatincontrolprimary prevention Exploratory -
PROSPER, 2002pravastatinplacebosecondary prevention Low risk of bias Conclusive
PROSPER diabetic (sub group), 2002pravastatinplacebodiabetic patients Exploratory Negative
PROSPER (primary prevention subgroup), 2002pravastatinplaceboprimary prevention Exploratory Negative
ALLHAT (women subgroup) , 2002Pravastatinplacebowomen Exploratory Negative
ALLHAT-LLT (diabetic sub group), 2002pravastatinusual carediabetic patients Exploratory Negative
ALLHAT, 2002pravastatinusual careat risk hypertensive Risk of bias NegativeNCT00000542
PTT, 2002pravastatinusual careacute coronary syndrome Exploratory Suggesting
PACT, 2004pravastatinplacebosecondary prevention Low risk of bias Negative
PACT, 2004pravastatinplaceboacute coronary syndrome Low risk of bias Suggesting
PHYLLIS, 2004pravastatinplacebodiabetic Exploratory -
PREVEND IT, 2004pravastatinplaceborelated disease Low risk of bias Negative
MEGA, 2006pravastatincontrolprimary prevention Risk of bias SuggestingNCT00211705
MEGA (women subgroup) , 2006Pravastatinplacebowomen Exploratory Suggesting
PROVE IT TIMI 22 (diabetic sub group), 2006pravastatin high dosepravastatindiabetic patients Exploratory -

diabetes type 2

WOSCOPS (diabetic sub group), 1996pravastatinplacebodiabetic patients Exploratory -
CARE (diabetic sub group), 1998pravastatinplacebodiabetic patients Exploratory Suggesting
LIPID (diabetic sub group), 1998pravastatinplacebodiabetic patients Exploratory Negative
GISSI P (diabetic sub group), 2000pravastatinusual carediabetic patients Exploratory -
PROSPER diabetic (sub group), 2002pravastatinplacebodiabetic patients Exploratory Negative
ALLHAT-LLT (diabetic sub group), 2002pravastatinusual carediabetic patients Exploratory Negative
PROVE IT TIMI 22 (diabetic sub group), 2006pravastatin high dosepravastatindiabetic patients Exploratory -

percutaneous coronary intervention

PREDICT, 1997pravastatinplaceboNegative

post myocardial infarction

CARE, 1996pravastatinplacebosecondary prevention Low risk of bias Conclusive
LIPID, 1998pravastatinplacebosecondary prevention Low risk of bias Conclusive
PACT, 2004pravastatinplacebosecondary prevention Low risk of bias Negative



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