Clinical trials in obesity and overweight

Trial	Studied treatment	Control treatment	ROB	Result	NCT
cannabinoid-1 receptor blocker
rimonabant
RIO europe 20mg, 2005	rimonabant 20mg	placebo		Suggesting
Rio-lipid 20 mg, 2005	rimonabant 20mg	placebo		Suggesting
RIO europe 5mg, 2005	rimonabant 5mg	placebo	Exploratory	-
RIO europe (20 vs 5 mg), 2005	rimonabant 20mg	rimonabant 5mg		-
RIO-North America 20 mg, 2006	rimonabant 20mg	placebo		Suggesting	NCT00029861
CRESCENDO, 2010	rimonabant	placebo	Low risk of bias	Negative	NCT00263042
AUDITOR ongoing	rimonabant	placebo		-
weight-loss drugs
Bupropion
Anderson, 2002	Bupropion	placebo		-
Croft, 2002	Bupropion	placebo		-
Jain, 2002	Bupropion	placebo		-
liraglutide
Astrup (NN8022-1807 ), 2009	liraglutide	placebo		-	NCT00422058
lorcaserin
BLOOM-DM (10mg bid)	lorcaserin	placebo		-	NCT00603291
BLOSSOM (10mg bid), 2009	lorcaserin	placebo		-	NCT00603902
BLOOM, 2010	lorcaserin	placebo		-	NCT00395135
orlistat
Sjostrom, 1998	Orlistat	placebo		-
Hollander, 1998	Orlistat	placebo		-
Davidson, 1999	Orlistat	placebo		-
Micic, 1999	Orlistat	placebo		-
Vidgren, 1999	Orlistat	placebo		-
Hill, 1999	Orlistat	placebo		-
Lindgarde, 2000	Orlistat	placebo		-
Rossner, 2000	Orlistat	placebo		-
Hauptman, 2000	Orlistat	placebo		-
Karhunen, 2000	Orlistat	placebo		-
Broom,, 2001	Orlistat	placebo		-
Deerochanawong,, 2001	Orlistat	placebo		-
Gotfredsen, 2001	Orlistat	placebo		-
Reaven, 2001	Orlistat	placebo		-
Muls, 2001	Orlistat	placebo		-
Rissanen, 2001	Orlistat	placebo		-
Shi Yi, 2001	Orlistat	placebo		-
Bakris, 2002	Orlistat	placebo		-
Broom, 2002	Orlistat	placebo		-
Hanefeld, 2002	Orlistat	placebo		-
Kelley, 2002	Orlistat	placebo		-
Miles, 2002	Orlistat	placebo		-
Naumov, 2002	Orlistat	placebo		-
Rosenfalck, 2002	Orlistat	placebo		-
Derosa, 2003	Orlistat	placebo		-
Halpern, 2003	Orlistat	placebo		-
Lucas, 2003	Orlistat	placebo		-
Krempf, 2005	Orlistat	placebo		-
phentermine and topiramate
CONQUER (mid-dose) (OB 303)	PHEN/TPM mid-dose	placebo		-	NCT00553787
OB 302 (low-dose)	PHEN/TPM low-dose	placebo		-
OB 301 (mid-dose)	PHEN/TPM mid-dose	placebo		-
OB 301 (high-dose)	PHEN/TPM high dose	placebo		-
CONQUER (high-dose) (OB 303)	PHEN/TPM high dose	placebo		-	NCT00553787
OB 302 (high-dose)	PHEN/TPM high dose	placebo		-
Sibutramine
McMahon, 2000	Sibutramine	placebo		-
Smith, 2001	Sibutramine	placebo		-
McMahon, 2002	Sibutramine	placebo		-
SCOUT, 2010	sibutramine	placebo	Low risk of bias	-	NCT00234832
topiramate
Bray, 2003	Topiramate	placebo		-
Caterson, 2003	Topiramate	placebo		-
Pud’homme, 2003	Topiramate	placebo		-
Rissanen, 2003	Topiramate	placebo		-
Stenlof, 2003	Topiramate	placebo		-
Tonstad, 2003	Topiramate	placebo		-

obesity and overweight Description Results

Group by...

obesity and overweight
Description Results