Captopril angiotensin-Converting Enzyme Inhibitors

Lopirin - Capoten - SQ14225 - SQ 14225 - SQ-14225 - SQ14534 - SQ 14534 - SQ-14534



Trial Studied treatment Control Patients Size Study type Results NCT

Acute myocardial infarction - angiotensin-Converting Enzyme Inhibitors in systematic early treatment (with or without sign of HF) - angiotensin-Converting Enzyme Inhibitors in patients with or without HF - angiotensin-Converting Enzyme Inhibitors in patients with left ventricular dysfunction after MI

Bussmann, 1992captoprilplacebo46 (22/24) Exploratory
SAVE, 1992captoprilplacebo2231 (1115/1116) Confirmatory
CATS, 1996captoprilplacebo298 (149/149) Exploratory
CCS-1, 1995captoprilplacebo13634 Confirmatory
Di Pasquale, 1997captoprilplacebo61 (31/30) Exploratory
Pfeffer, 1988captoprilplacebo38 Exploratory
Di Pasquale, 1994captoprilplacebo371 (188/183) Exploratory
Sogaard, 1994captoprilplacebo58 Exploratory
ECCE, 1997captoprilplacebo208 (104/104) Exploratory
Sharpe, 1988captoprilplacebo60 Exploratory
Mortarino, 1990captoprilplacebo21 (10/11) Exploratory
French, 1999captoprilplacebo493 (243/250) Exploratory
Galcera, 1993captoprilplacebo43 (21/22) Exploratory
Hargreaves, 1992captoprilplacebo72 (36/36) Exploratory
ISIS-4, 1995captoprilplacebo58050 (29028/29022) Confirmatory
Nabel, 1991captoprilplacebo38 (20/18) Exploratory
Ray, 1993captoprilplacebo99 Exploratory
Sharpe, 1991captoprilplacebo100 Exploratory
PRACTICAL (captopril), 1994captopril or enalaprilplacebo225 (150/75) Exploratory

Diabetes type 2 - anti hypertensive agents in patients with hypertension - anti hypertensive agents in patients with or without hypertension - angiotensin renin system blockade in all type of patients

UKPDS 39, 1998captoprilatenolol758 (400/358) Exploratory
CAPP (diabetic subgroup), 1999captoprildiuretic and/or beta-blockers572 (309/263) Exploratory
UKPDS 38, 1998captopril or atenololcontrol1148 (758/390) Exploratory

Heart failure - angiotensin-Converting Enzyme Inhibitors in all type of heart failure - angiotensin-Converting Enzyme Inhibitors in elderly - angiotensin-Converting Enzyme Inhibitors in MI patients with LV dysfunction without clinical evidence of HF

packer, 1986captoprilenalapril42 (21/21) Exploratory
SAVE, 1992captoprilplacebo2231 (1115/1116) Confirmatory
Barabino, 1991captoprilplacebo101 (52/49) Exploratory
Pfeffer, 1988captoprilplacebo38 Exploratory
Bussmann, 1987captoprilplacebo23 (12/11) Exploratory
Sogaard, 1994captoprilplacebo58 Exploratory
Captopril Digoxin Multicenter Research Group, 1988captoprilplacebo204 (104/100) Confirmatory
Sharpe, 1988captoprilplacebo60 Exploratory
Mortarino, 1990captoprilplacebo21 (10/11) Exploratory
Cilazapril-Captopril Multi-centre Group (capt vs pbo), 1995captoprilplacebo222 (108/114) Exploratory
CMRG, 1983captoprilplacebo92 (50/42) Exploratory
Magnani, 1986captoprilplacebo94 (48/46) Exploratory
Magnani, 1990captoprilplacebo32 (16/16) Exploratory
Munich MHFT (Kleber), 1992captoprilplacebo170 (83/87) Confirmatory

Hypertension - anti hypertensive agents in diabetic patients - anti hypertensive agents in all type of patient - angiotensin-receptor blockers in all diseases requiring ACEi (HF, CHD, HT,...)

UKPDS 39, 1998captoprilatenolol758 (400/358) Exploratory
CAPP (diabetic subgroup), 1999captoprildiuretic and/or beta-blockers572 (309/263) Exploratory
CAPPP, 1999captoprildiuretic or beta-blocker10985 (5492/5493) Confirmatory -
UKPDS-HDS, 1998captoprildiuretic or beta-blocker758 (400/358)
UKPDS 38, 1998captopril or atenololcontrol1148 (758/390) Exploratory
VALIANT/Val+Cap, 2003Valsartan + captoprilCaptopril9794 (4885/4909) Confirmatory



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