Ivabradine HR-slowing agents

S-16257 - S 16257 - S 16260-2 - S-16260-2 - S-16257-2 - S 16257-2 - Procorolan - Corlanor - ivabradine



Trial Studied treatment Control Patients Size Study type Results NCT

Heart failure - HR-slowing agents in all type of patients

SHIFT, 2010ivabradineplacebo6505 (3241/3264) Confirmatory ISRCTN70429960
BEAUTIFUL, 2008ivabradine 15mgplacebo10917 (5479/5438) Confirmatory NCT00143507

Stable angina - HR-slowing agents in all type of patients - HR-slowing agents in patients with left ventricular dysfunction

CL3-023 (15mg)ivabradineamlodipine779 (381/398) Confirmatory
CL3-023 (20mg)ivabradineamlodipine774 (376/398) Confirmatory
Borer (CL2-009) 10mg, 2003ivabradine 10mgplacebo182 (91/91)
CL3-018 10mgivabradine 10mgplacebo on top of amlodipine484 (232/252)
Ruzyllo (CL3-023) 15mg, 2007ivabradine 15mgamlodipine804 (400/404) Confirmatory
INITIATIVE (CL3-017, Tardif) 15mg, 2005ivabradine 15mgatenolol622 (315/307)
BEAUTIFUL, 2008ivabradine 15mgplacebo10917 (5479/5438) Confirmatory NCT00143507
BEAUTIFUL (angina subgroup)ivabradine 15mgplacebo (on top standard treatment)1507 (734/773) Exploratory
CL3-018 15mgivabradine 15mgplacebo on top of amlodipine496 (244/252)
ASSOCIATE (Tardif), 2009ivabradine 15mgplacebo on top of atenolol889 (449/440) Confirmatory NCT00202566
Ruzyllo (CL3-023) 20mg, 2007ivabradine 20mgamlodipine795 (391/404) Confirmatory
INITIATIVE (CL3-017, Tardif) 20mg, 2005ivabradine 20mgatenolol624 (317/307) Confirmatory
SIGNIFY, 2014ivabradine 20mgplacebo19102 (9550/9552) ISRCTN61576291
Borer (CL2-009) 20mg, 2003ivabradine 20mgplacebo179 (88/91)
Borer (CL2-009) 5mg, 2003ivabradine 5mgplacebo181 (90/91)



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