Ceritinib ALK inhibitors

LDK378 - Zykadia - ceritinib



Trial Studied treatment Control Patients Size Study type Results NCT

Advanced breast cancer (metastatic) - angiogenesis inhibitors in all type of patients

Hyamscediranib + fulvestrantfulvestrantNA NCT00454805

Lung cancer (metastatic) - ALK inhibitors in ALK positive patients - angiogenesis inhibitors in all type of patients

Laurie, 2014cediranib carboplatin and paclitaxel NA
Goss, 2010cediranib carboplatin and paclitaxel NA
Dy, 2013cediranib gemcitabine and carboplatin NA
ASCEND-4, 2017ceritinibchemotherapy1L376 (189/187) Confirmatory - NCT01828099
ASCEND 5, 2017ceritinibpemetrexed or docetaxel2L after crizotinib failureNA NCT01828112