Trial Studied treatment Control Patients Size Study type Results NCT

Cardiovascular prevention - plasma homocysteine lowering intervention in all type of patients - plasma homocysteine lowering intervention in patients with chronic kidney disease

FOLARDA (Liem), 2004folic acidcontrol283 (140/143) Exploratory
GOES (Liem), 2003folic acidcontrol593 (300/293) Confirmatory -
CSPPT, 2015folic acidplacebo20702 (10348/10354) Confirmatory NCT00794885
CHAOS-2, 2002folic acidplacebo1882 (942/940)
NORVIT (folic acid + B12) (Bonaa), 2006folic acid, B12control3749 (1872/1877) Confirmatory NCT00266487
WENBIT (folic ac,B12), 2008folic acid, B12placebo1552 (772/780) Confirmatory NCT00354081
SEARCH, 2007folic acid, B12placebo12064 (6033/6031) Confirmatory NCT00124072
NORVIT (folic acid, B12 and vit B6) (Bonaa), 2006folic acid, vit B12 and vit B6control1880 (937/943) Confirmatory NCT00266487
VITATOPS, 2010folic acid, vit B12 and vit B6placebo8164 (4089/4075) Confirmatory NCT00097669ÐX&
SU.FOL.OM3folic acid, vit B12 and vit B6placebo2501 (1242/1259) ISRCTN41926726
HOPE-2 (Lonn), 2006folic acid, vit B12 and vit B6placebo5522 (2758/2764) Confirmatory NCT00106886
WAFACS, 2008folic acid, vit B12 and vit B6placebo5442 (2721/2721) Confirmatory NCT00000541
VISP (Toole), 2004high dose - folic acid, vit B12 and vit B6low dose - folic acid, vit B12 and vit B63680 (1827/1853) Confirmatory

Post stroke - prevention in patients with prior stroke or TIA

VITATOPS, 2010folic acid, vit B12 and vit B6placebo8164 (4089/4075) Confirmatory NCT00097669ÐX&
VISP (Toole), 2004high dose - folic acid, vit B12 and vit B6low dose - folic acid, vit B12 and vit B63680 (1827/1853) Confirmatory



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