metformin clinical trials - description and results

Trial	Studied treatment	Control	Size	Study type	NCT
Diabetes type 2 - insulin sensitizer in all type of patients - insulin sensitizer - biguanides in all type of patients - prevention in all type of patients - prevention in people with impaired glucose tolerance
IDDP (Ramachandran), 2006	lifestyle modification + metformin	control	531	Confirmatory -
Jarret, 1979	lifestyle modification + metformin	control	204	Exploratory
James, 2005	metformin	control	20 (10/10)
Campbell, 1994	metformin	Glipizide	48 (24/24)
Baillargeon, 2004	metformin	placebo	64 (32/32)
Bridger, 2006	metformin	placebo	22 (11/11)
Charles, 1998	metformin	placebo	457 (227/230)
Charles, 2000	metformin	placebo	168 (83/85)
Choux, 2003	metformin	placebo	32 (15/17)
Crave, 1995	metformin	placebo	24 (12/12)
EDIT (Holman), 2003	metformin	placebo	631
Fleming, 2002	metformin	placebo	92 (45/47)
Teupe, 1991	metformin	placebo	100 (50/50)
Freemark, 2001	metformin	placebo	32 (16/16)
Gambineri, 2004	metformin	placebo	20 (10/10)
Giugliano, 1993	metformin	placebo	24 (12/12)
Hoeger, 2004	metformin	placebo	38 (18/20)
Kooy (HOME), 2009	metformin	placebo	390 (196/194)	Confirmatory
Kay, 2001	metformin	placebo	24 (12/12)
Kelly, 2002	metformin	placebo	32 (16/16)
Kocak, 2002	metformin	placebo	56 (28/28)
Lehtovirta, 2001	metformin	placebo	40 (20/20)
Li, 1999	metformin	placebo	70 (33/37)	Exploratory
Moghetti, 2000	metformin	placebo	23 (12/11)
Morel, 1999	metformin	placebo	38 (19/19)
Ng, 2001	metformin	placebo	20 (10/10)
Orchard, 2005	metformin	placebo	2155 (1073/1082)
Pasquali, 2000	metformin	placebo	40 (20/20)
Rodriguez, 2004	metformin	placebo	21 (10/11)
Rodriguez-Moctezuma, 2004	metformin	placebo	23 (12/11)
Sirtori, 1984	metformin	placebo	30 (15/15)
Srinivasan, 2006	metformin	placebo	56 (28/28)
Stakos, 2005	metformin	placebo	156 (59/97)
Sturrock, 2002	metformin	placebo	34 (17/17)
Tang, 2006	metformin	placebo	143 (69/74)
US-DPP (metformin) (Knowler), 2002	metformin	placebo	3234	Confirmatory
Vitale, 2005	metformin	placebo	65 (32/33)
UKPDS (vs SU or INS)	metformin	SU/Insulin	1293 (342/951)
CANOE, 2010	rosiglitazone and metformin	placebo	207 (103/104)	Confirmatory	NCT00116932
Impaired fasting glucose - prevention in all type of patients
US-DPP (metformin) (Knowler), 2002	metformin	placebo	3234	Confirmatory
CANOE, 2010	rosiglitazone and metformin	placebo	207 (103/104)	Confirmatory	NCT00116932

Metformin antidiabetic drugs

Glucophage - Dimethylbiguanidine - Dimethylguanylguanidine - Metformin

Diabetes type 2 - insulin sensitizer in all type of patients - insulin sensitizer - biguanides in all type of patients - prevention in all type of patients - prevention in people with impaired glucose tolerance

Impaired fasting glucose - prevention in all type of patients