Aspirin antiplatelets drug



Trial Studied treatment Control Patients Size Study type Results NCT

Acute coronary syndrome - antithrombotics in all type of patients - antiplatelets drug in ACS (excluding AMI) - antiplatelets drug in all type of patients - antiplatelets drug in STEMI patients

Huddinge, 1988aspirincontrol20 (10/10)
ATACS-pilot, 1990aspirincontrol61 (37/24)
Frankfurt, 1976aspirincontrol53 (25/28)
VA-main, 1983aspirinplacebo1338 (661/677)
ISIS-pilot, 1987aspirinplacebo619 (313/306)
ISIS-2, 1988aspirinplacebo17187 (8587/8600)
VA-pilotaspirinplacebo50 (26/24)
RISC, 1990aspirinplacebo945 (474/471)
Canadian (Aspirin vs PBO), 1985aspirinplaceboNA
ALDUSA-pilotaspirinplacebo84 (56/28)
Dutch-aspirin, 1990aspirinplacebo100 (50/50)
Théroux, 1988aspirinplacebo239 (121/118)
APRICOT, 1993aspirinplacebo202 (107/95)
Canadian (Aspirin + sulfinpyrazone), 1985aspirin + sulfinpyrazoneplacebo555 (416/139)

Acute myocardial infarction - antiplatelets drug in all type of patients

Huddinge, 1988aspirincontrol20 (10/10)
Frankfurt, 1976aspirincontrol53 (25/28)
ISIS-pilot, 1987aspirinplacebo619 (313/306)
ISIS-2, 1988aspirinplacebo17187 (8587/8600)
Dutch-aspirin, 1990aspirinplacebo100 (50/50)
APRICOT, 1993aspirinplacebo202 (107/95)

Atrial fibrillation - antithrombotics in primary prevention of thromboembolic events - antithrombotics in patients ineligible for warfarin - antithrombotics in secondary prevention of thromboembolic events

LASAF(aspirin vs no treatment), 1999aspirincontrolNA
PATAF (vs coumadin low dose), 1999aspirincoumadin low dose598 (319/279) Confirmatory -
PATAF (vs coumadin standard dose), 1999aspirincoumadin standard dose272 (141/131) Confirmatory -
EAFT, 1993aspirinplacebo782 (404/378)
AFASAK (aspirin vs placebo), 1989aspirinplacebo672 (336/336) Confirmatory
SPAF (aspirin , warfarin eligible arm), 1991aspirinplacebo417 (206/211) Confirmatory
SPAF (aspirin,warfarin ineligible arm), 1991aspirinplaceboineligible for VKA703 (346/357) Confirmatory
FFAACS , 2001aspirinplacebo (on top fluidione)157 (76/81)
AFASAK II (aspirin vs warfarin low dose), 1998aspirinwarfarin low dose336 (169/167) Confirmatory -
AFASAK (aspirin vs warfarin standard dose), 1989aspirinwarfarin standard dose671 (336/335) Confirmatory -
AFASAK II (aspirin vs warfarin standard dose), 1998aspirinwarfarin standard dose339 (169/170) Confirmatory -
BAFTA (aspirin vs warfarin standard dose) ongoing aspirinwarfarin standard doseNA
SPAF II (aspirin vs warfarin standard dose, age<75), 1994aspirinwarfarin standard dose715 (357/358) Confirmatory -
SPAF II (aspirin vs warfarin standard dose, age>75), 1994aspirinwarfarin standard dose385 (188/197) Confirmatory -

CABG surgery - antiplatelets drug in all type of patients

McEnany, 1982aspirinplacebo148 (71/77)
Lorenz, 1984aspirinplacebo60 (29/31)
GESIC (aspirin), 1990aspirinplacebo744 (373/371)
Sydney, 1991aspirinplacebo237 (127/110)
Hockings, 1993aspirinplacebo144 (72/72)

Cardiovascular prevention - antiplatelets drug in secondary prevention in patients with CAD - antiplatelets drug in secondary prevention in patients with intermittent claudication - antiplatelets drug in all type of patients - antiplatelets drug in primary prevention - antiplatelets drug in patients without established disease - antiplatelets drug in diabetic patients

JPPP ongoing aspirinno aspirinprimary preventionNA Confirmatory - NCT00225849
British Doctor’s Trial, 1988aspirinno treatmentprimary prevention5139 (3429/1710) Confirmatory -
PPP (diabetics sub group), 2003aspirinno treatment1031 (519/512) Exploratory
Primary Prevention Project, 2001aspirinno treatmentprimary prevention4495 (2226/2269) Confirmatory -
JPAD, 2008aspirinno treatment2539 (1262/1277) Confirmatory - NCT00110448
CLIPS, 2007aspirinplacebo366 (185/181) Confirmatory
AAA, 2009aspirinplacebosecondary prevention3350 (1675/1675) Confirmatory ISRCTN66587262
ASPREE, 2018aspirinplaceboNA NCT01038583
ASCEND, 2018aspirinplaceboNA NCT00135226
PHS (diabetics sub group), 1989aspirinplacebo533 (275/258) Confirmatory
Munich B, 1975aspirinplacebo82 (42/40)
Physicians Health Study, 1989aspirinplaceboprimary prevention22071 (11037/11034) Confirmatory NCT00000500
ETDRS, 1992aspirinplacebo3711 (1856/1855) Confirmatory
Thrombosis Prevention Trial, 1998aspirinplaceboprimary prevention5085 (2545/2540) Confirmatory NCT00000614
Cardiff I, 1974aspirinplacebo1239 (615/624)
Cardiff II, 1979aspirinplacebo1682 (832/850)
Vogel, 1979aspirinplacebo1340 (672/668)
AMIS, 1980aspirinplacebo4524 (2267/2257) NCT00000491
GAMIS, 1980aspirinplacebo626 (317/309)
PARIS, 1980aspirinplacebo1216 (810/406)
JAMIS, 1999aspirinplacebo480 (250/230)
Munich A, 1975aspirinplacebo176 (92/84)
ACCEPT-D ongoing aspirinplaceboNA Confirmatory - ISRCTN48110081
HOT, 1998aspirinplaceboprimary prevention18790 (9399/9391) Confirmatory
ASCEND (aspirin) ongoing aspirinplaceboNA NCT00135226
CDPA, 1976aspirinplacebo1529 (758/771)
WHS (diabetics sub group), 2005aspirinplacebo1027 (514/513) Exploratory
POPADAD aspirin, 2008aspirinplacebo1276 (638/638) Confirmatory ISRCTN53295293
Women’s Health Study, 2005aspirinplaceboprimary prevention39876 (19934/19942) Confirmatory
SAPAT, 1992aspirinplacebo2035 (1009/1026) Confirmatory
Schoop, 1983aspirinplacebo200 (100/100)
DAMAD, 1989aspirinplacebo475 (318/157) Confirmatory
Hess, 1985aspirinplacebo160 (80/80)

Coronary artery disease - death and events prevention in all type of patients

CDPA, 1976aspirinplacebo1529 (758/771)
Cardiff I, 1974aspirinplacebo1239 (615/624)
Cardiff II, 1979aspirinplacebo1682 (832/850)
Vogel, 1979aspirinplacebo1340 (672/668)
AMIS, 1980aspirinplacebo4524 (2267/2257) NCT00000491
GAMIS, 1980aspirinplacebo626 (317/309)
PARIS, 1980aspirinplacebo1216 (810/406)
JAMIS, 1999aspirinplacebo480 (250/230)
SAPAT, 1992aspirinplacebo2035 (1009/1026) Confirmatory

Diabetes type 2 - antiplatelets drug in patients without cardiovascular disease - antiplatelets drug in all type of patients

PPP (diabetics sub group), 2003aspirinno treatment1031 (519/512) Exploratory
JPAD, 2008aspirinno treatment2539 (1262/1277) Confirmatory - NCT00110448
PHS (diabetics sub group), 1989aspirinplacebo533 (275/258) Confirmatory
ETDRS, 1992aspirinplacebo3711 (1856/1855) Confirmatory
ASCEND (aspirin) ongoing aspirinplaceboNA NCT00135226
ACCEPT-D ongoing aspirinplaceboNA Confirmatory - ISRCTN48110081
WHS (diabetics sub group), 2005aspirinplacebo1027 (514/513) Exploratory
POPADAD aspirin, 2008aspirinplacebo1276 (638/638) Confirmatory ISRCTN53295293
DAMAD, 1989aspirinplacebo475 (318/157) Confirmatory

Heart failure - antithrombotics in all type of patients

WASH (aspirin), 2004aspirinno treatment190 (91/99)
Barzizza (ASA), 1993aspirinplacebo49 (26/23) Exploratory

Hypertension - antiplatelets drug in all type of patients

HOT, 1998aspirinplaceboprimary prevention18790 (9399/9391) Confirmatory

Percutaneous coronary intervention - antithrombotics in all type of patients

Taylor (Perth), 1991aspirinplacebo252 (124/128)
M-HEART II (aspirin), 1995aspirinplacebo1007 (497/510)

Peripheral vascular diseases - antithrombotics in all type of patients - antiplatelets drug in all type of patient - antithrombotics in after revascularisation

BOA, 2000aspirin2690 (1351/1339)
Lassila R, 1991aspirincontrôle144 (72/72)
CLIPS, 2007aspirinplacebo366 (185/181) Confirmatory
Munich B, 1975aspirinplacebo82 (42/40)
Munich A, 1975aspirinplacebo176 (92/84)
Schoop, 1983aspirinplacebo200 (100/100)
Hess, 1985aspirinplacebo160 (80/80)

Post myocardial infarction - antiplatelets drug in all type of patient - secondary prevention in all type of patients

CDPA, 1976aspirinplacebo1529 (758/771)
Cardiff I, 1974aspirinplacebo1239 (615/624)
Cardiff II, 1979aspirinplacebo1682 (832/850)
Vogel, 1979aspirinplacebo1340 (672/668)
AMIS, 1980aspirinplacebo4524 (2267/2257) NCT00000491
GAMIS, 1980aspirinplacebo626 (317/309)
PARIS, 1980aspirinplacebo1216 (810/406)
JAMIS, 1999aspirinplacebo480 (250/230)

Post stroke - antiplatelets drug in all type of patients

Canadian study (CCSG), 1978aspirinplacebo283 (144/139)
Swedish study , 1987aspirinplacebo505 (253/252)
UK-TIA low dose , 1988aspirinplacebo1620 (806/814)
UK-TIA high dose , 1988aspirinplacebo1629 (815/814)
SALT , 1991aspirinplacebo1360 (676/684)
Reuther , 1976aspirinplacebo60 (30/30)
AITA, 1975aspirinplacebo319 (162/157)
DCS, 1980aspirinplacebo203 (101/102)
AICLA, 1981aspirinplacebo402 (198/204)
Lindblad , 1991aspirinplacebo232 (117/115)
Danish low-dose, 1986aspirinplacebo301 (150/151)
ESPS 2 , 1996aspirinplacebo3298 (1649/1649)

Stable angina - antithrombotics in all type of patient

SAPAT, 1992aspirinplacebo2035 (1009/1026) Confirmatory

Thrombosis prevention - antithrombotics in orthopedic surgery - antithrombotics in hip Fracture - antithrombotics in general surgery - antiplatelets drug in general surgery - antiplatelets drug in all type of patients - antithrombotics in elective hip replacement - antiplatelets drug in orthopedic surgery - antiplatelets drug in elective orthopedic surgery - antithrombotics in elective major knee surgery - mechanical devices for thromboprophylaxis in all type of patients

Clagett, 1975aspirincontrol105 (56/49) Confirmatory -
Zekert VI, 1982aspirincontrol100 (50/50) Confirmatory -
Pasteyer, 1977Aspirinno treatment40 (20/20) Exploratory
Rocha, 1986Aspirinno treatment90 (60/30) Exploratory
MRC, 1972aspirinplacebo303 (153/150) Confirmatory
Loew DVT, 1974aspirinplacebo1381 (702/679) Confirmatory
Erfurt-A, 1979aspirinplacebo714 (357/357) Confirmatory
Zekert V, 1980aspirinplacebo99 (50/49) Confirmatory
Vinazzer I, 1980aspirinplacebo806 (402/404) Confirmatory
Vinazzer II, 1977aspirinplacebo124 (62/62) Confirmatory
Zekert-I , 1974Aspirinplacebo278 (138/140) Exploratory
Powers , 1976Aspirinplacebo129 (66/63) Exploratory
Erfurt-B , 1979Aspirinplacebo88 (44/44) Exploratory
PEP hip-fracture, 2000aspirinplacebo13356 (6679/6677) Confirmatory
PEP elective arthroplasty, 2000aspirinplacebo4088 (2047/2041) Confirmatory
Stockholm-I, 1975Aspirinplacebo51 (26/25) Exploratory
Harris-I, 1977Aspirinplacebo117 (58/59) Confirmatory
McKenna-I, 1980Aspirinplacebo36 (24/12) Exploratory
Sautter, 1983Aspirinplacebo145 (68/77) Exploratory
McBride, 1983Aspirinplacebo43 (21/22) Exploratory
Gelfer, 2006CECT + aspirinLMWHNA
Hull 2 (+asp), 1979IPC + aspirinaspirinNA
Hull (+asp), 1979IPC + aspirinaspirinNA
Lieberman (A), 1994IPC + aspirinaspirin260 (130/130)

Venous thrombosis - antithrombotics in secondary prevention of VTE

WARFASA, 2012aspirindiscontinuation402 (205/197) NCT00222677
ASPIRE, 2012aspirindiscontinuation822 (411/411) ACTRN12605000004662



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