Enoxaparin LMWH

Clexane - Lovenox



Trial Studied treatment Control Patients Size Study type Results NCT

Acute coronary syndrome - antithrombotics in all type of patients - heparin (UFH or LMWH) in all type of patients - antithrombotics in unstable angina

EVET, 2005enoxaparintinzaparin438 (220/218)
ESSENCE, 1997enoxaparinUFH (on top of aspirin)3171 (1607/1564)
INTERACT, 2006enoxaparinUFH (on top of aspirin)746 (380/366)
SYNERGY, 2005enoxaparinUFH (on top of aspirin)9978 (4993/4985) NCT00043784
TIMI 11 B (long term), 1998enoxaparinUFH (on top of aspirin)3910 (1953/1957)
TIMI 11 B (short term), 1998enoxaparinUFH (on top of aspirin)3910 (1953/1957)
RESCUEenoxaparinunfractionated heparinNA NCT00077818

Acute myocardial infarction - antithrombotics in all type of patients - heparin (UFH or LMWH) in patients eligible to receive fibrinolytic therapy

AMI-SK, 2002Enoxaparinplacebo496 (253/243)
ASSENT 3 Plus, 2003EnoxaparinUFH1639 (818/821)
ASSENT 3, 2001EnoxaparinUFH4078 (2040/2038)
Baird, 2002EnoxaparinUFH300 (149/151)
ENTIRE-TIMI 2, 2002EnoxaparinUFH242 (160/82)
HART II, 2001EnoxaparinUFH400 (200/200)

Heart failure - antithrombotics in patients hospitalized for heart failure

THE-PRINCE (Kleber), 2003enoxaparinUFH333 (164/169)

Percutaneous coronary intervention - antithrombotics in all type of patients - anticoagulant in all type of patients - antithrombotics in MI patients undergoing primary PCI - anticoagulant in patients undergoing primary PCI

ATOLL, 2010enoxaparinUFH910 (450/460) Confirmatory -
CRUISE, 2003enoxaparinUFH261 (129/132) Exploratory
Drozd, 2001enoxaparinUFH100 (50/50)
Dudek, 2000enoxaparinUFH400 (200/200)
Dudek b (enox alone), 2000enoxaparinUFHNA
Galeote, 2001enoxaparinUFH99 (50/49)
Rabah, 1999enoxaparinUFH60 (30/30) Exploratory
STEEPLE, 2006enoxaparinUFHNA Confirmatory - NCT00077844
STREAM ongoing enoxaparinunfractionated heparinNA NCT00882635
Dubek b (+abciximal), 2001enoxaparin+abciximabUFHNA

Pulmonary embolism - antithrombotics in all type of patients

PREPIC, 1998Enoxaparinunfractionated heparin95 (41/54) Confirmatory -
Merli sub group, 2001Enoxaparinunfractionated heparin287 (199/88) Exploratory

Superficial thrombophlebitis - antithrombotics in superficial thrombophlebitis of the leg

STENOX (enoxaparin 1.5mg/hg), 2003enoxaparinplaceboNA
Stenox (enoxaparin 40mg), 2003enoxaparinplaceboNA

Thrombosis prevention - antithrombotics in urologic surgery - UFH in urologic surgery - antithrombotics in orthopedic surgery - antithrombotics in elective hip replacement - heparin (UFH or LMWH) in orthopedic surgery - LMWH in orthopedic surgery - antithrombotics in elective major knee surgery - antithrombotics in medical patients - LMWH in medical patients - antithrombotics in general surgery - heparin (UFH or LMWH) in general surgery - LMWH in general surgery - antithrombotics in gynaecological surgery - LMWH in gynaecological surgery - antithrombotics in abdominal surgery - LMWH in abdominal surgery - antithrombotics in neurosurgery - heparin (UFH or LMWH) in neurosurgery - LMWH in neurosurgery - antithrombotics in arthroscopy

Canata, 2003enoxaparincontrol36 (18/18) Exploratory
DES Group , 1991enoxaparinDextranhip surgery246 (120/126)
Ho [43]enoxaparinno treatment303 (134/169)
Warwick, 1995enoxaparinno treatmenthip surgery156 (78/78)
LIFENOX, 2011enoxaparinplacebomedical patients8307 (4171/4136) Confirmatory NCT00622648
Lederle, 2006Enoxaparinplacebomedical patients280 (140/140)
MEDENOX, 1999Enoxaparinplacebomedical patients579 (291/288) Confirmatory
Kalodiki, 1996enoxaparinplacebohip surgery27 (13/14)
LeGagneux , 1987enoxaparinplacebo89 (44/45)
Leclerc, 1991enoxaparinplaceboknee surgery129 (65/64)
Samama, 1997enoxaparinplacebohip surgery170 (85/85)
Turpie, 1986enoxaparinplacebohip surgery100 (50/50)
Agnelli, 1998enoxaparinplacebo307 (153/154)
Melon, 1987enoxaparinplacebo130 (67/63)
Bergmann and Neuhart, 1996enoxaparinUFHmedical patientsNA
Lechler, 1996enoxaparinUFHmedical patientsNA
Kleber, 2003enoxaparinUFHmedical patientsNA
Samama 2, 1988enoxaparinunfractionated heparingeneral surgery250 (127/123)
Samama 1, 1988enoxaparinunfractionated heparingeneral surgery335 (168/167)
Levine , 1991enoxaparinUnfractionated heparinhip surgery665 (333/332)
Samama 3, 1988enoxaparinunfractionated heparingeneral surgery307 (160/147)
Planes , 1988enoxaparinUnfractionated heparinhip surgery237 (124/113)
Kaaja, 1992enoxaparinunfractionated heparingynaecological surgery68 (37/31)
Gazzaniga (ISG), 1993enoxaparinunfractionated heparingeneral surgery1122 (561/561)
Nurmohamed, 1995enoxaparinunfractionated heparingeneral surgery1471 (737/734)
McLeod (Canadian), 1995enoxaparinunfractionated heparinabdominal surgery1349 (674/675)
Gonzalez, 1996enoxaparinunfractionated heparinabdominal surgery166 (84/82)
ENOXACAN, 1997enoxaparinunfractionated heparinabdominal surgery1115 (555/560)
Bergqvist, 1996out of hospital Enoxaparinstandard prophylaxis233 (117/116)
Planes, 1996out of hospital Enoxaparinstandard prophylaxis179 (90/89)
Comp, 2001out of hospital Enoxaparinstandard prophylaxis873 (441/432)

Venous thrombosis - antithrombotics in all type of patients - LMWH in all type of patients - heparin (UFH or LMWH) in all type of patients - antithrombotics in patients with cancer

Veiga, 2000Enoxaparinacenocoumarol100 (50/50) Confirmatory -
González-Fajardo, 2008Enoxaparincoumarin165 (85/80) Confirmatory -
Simonneau et al , 1993Enoxaparinunfractionated heparin134 (67/67)
Deitcher, 2003Enoxaparinwarfarin81 (51/30) Confirmatory -
Meyer, 2002Enoxaparinwarfarin129 (71/58) Confirmatory -
Gonzalez-Fajardo, 1999Enoxaparinwarfarin185 (93/92) Confirmatory -
Pini, 1994Enoxaparinwarfarin187 (93/94) Confirmatory -
Cesarone, 2003extended enoxaparinstandard treatmentNA
Deitcher, 2006extended enoxaparinstandard treatmentNA
Meyer, 2002extended enoxaparinstandard treatmentNA
Merli, 2001once daily enoxaparintwice daily enoxaparin610 (298/312)
Merli (once daily vs UFH), 2001once daily enoxaparinUFH588 (298/290) Confirmatory



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