Nadroparin LMWH

LMF CY216 - LMF CY 216 - LMF CY-216 - CY216 - CY-216 - CY 216 - Fraxiparine - Fraxiparin - Nadroparine



Trial Studied treatment Control Patients Size Study type Results NCT

Acute coronary syndrome - antithrombotics in all type of patients - heparin (UFH or LMWH) in all type of patients

FRAXIS (14 days), 1998nadroparinUFH (on top of aspirin)2302 (1151/1151)
FRAXIS (6days), 1998nadroparinUFH (on top of aspirin)2317 (1166/1151) Confirmatory

Pulmonary embolism - antithrombotics in all type of patients

European multicentre study, 1991Nadroparinunfractionated heparin108 (61/47) Confirmatory -
Prandoni sub-group, 1992Nadroparinunfractionated heparin91 (45/46) Exploratory
Thery, 1992Nadroparinunfractionated heparin68 (35/33) Exploratory

Superficial thrombophlebitis - antithrombotics in superficial thrombophlebitis of the leg

Titon (nadroparin 0.6ml vs naproxen), 1994nadroparinnaproxeneNA
Titon (nadroparin 61.5 IU anti-Xa/kg vs naproxen), 1994nadroparinnaproxeneNA
Vesalio, 2005nadroparin fixed-dosenadroparin weight-adjustedNA

Thrombosis prevention - antithrombotics in orthopedic surgery - antithrombotics in elective hip replacement - heparin (UFH or LMWH) in orthopedic surgery - LMWH in orthopedic surgery - antithrombotics in hip Fracture - antithrombotics in medical patients - LMWH in medical patients - antithrombotics in general surgery - heparin (UFH or LMWH) in general surgery - LMWH in general surgery - antithrombotics in abdominal surgery - LMWH in abdominal surgery - antithrombotics in neurosurgery - heparin (UFH or LMWH) in neurosurgery - LMWH in neurosurgery - antithrombotics in patients with immobilization of the lower extremities - antithrombotics in arthroscopy

KANT (7 days), 2008nadroparincontrol1317 (657/660) Confirmatory -
Kujath, 1993nadroparincontrol252 (126/126) Confirmatory -
PROTECT (nadroparin) ongoing nadroparinno treatmentNA NCT00881088
Marassi [41]nadroparinno treatment64 (31/33)
Yoo, 1997nadroparinno treatmenthip surgery100 (50/50)
Bergmann, 1996nadroparinplacebomedical patientsNA
Balas [40]nadroparinplacebo189 (94/95)
Fraisse, 2000Nadroparinplacebomedical patients223 (109/114)
Mahe, 2005Nadroparinplacebomedical patients2474 (1230/1244)
Sourmelis, 1995nadroparinplacebohip surgery150 (72/78)
Nurmohamed, 1996nadroparinplacebo485 (241/244)
Kakkar and Murray, 1985nadroparinunfractionated heparingeneral surgery400 (200/200)
EFS, 1988nadroparinunfractionated heparinabdominal surgery1909 (968/941)
Dahan, 1989nadroparinunfractionated heparinthoracic surgery87 (46/41)
Barbui, 1990nadroparinunfractionated heparingeneral surgery344 (171/173)
Eurin, 1994nadroparinunfractionated heparinabdominal surgery480 (241/239)
KANT (14 days), 2008nadroparin 14dcontrol1104 (444/660) Confirmatory -
NPHDO, 1998out of hospital Nadroparinstandard prophylaxis346 (173/173)

Venous thrombosis - antithrombotics in all type of patients - LMWH in all type of patients - heparin (UFH or LMWH) in all type of patients - antithrombotics in patients with cancer

Lopez Beret, 2001extended nadroparinstandard treatmentNA
Lopez-Beret, 2001Nadroparinacenocoumarol158 (81/77) Confirmatory -
Lopaciuk, 1999Nadroparinacenocoumarol202 (101/101) Confirmatory -
Collaborative European Multicentre, 1991Nadroparinunfractionated heparin136 (70/66)
Prandoni et al , 1992Nadroparinunfractionated heparin170 (85/85)
Lopaciuk et al , 1992Nadroparinunfractionated heparin149 (74/75)
Charbonnier, 1998once daily nadroparintwice daily nadroparin651 (316/335)



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