Exenatide antidiabetic drugs

AC 2993 - Byetta - AC 2993 LAR - exendin 4 - Ex4 peptide - exendin-4 - bydureon - exenatide



Trial Studied treatment Control Patients Size Study type Results NCT

Diabetes type 2 - insulin secretagogues peptides (incretins) in all type of patients - antidiabetic drugs in patients with insufficient glycaemic control with bitherapy - antidiabetic drugs in patients inadequately controlled with insulin - antidiabetic drugs in Patients inadequately controlled on MET+SU therapy - antidiabetic drugs in patients inadequately controlled on metformin - antidiabetic drugs in patients inadequately controlled on monotherapy - glucose lowering for cardiovascular prevention in all type of patients

NCT00360334exenatideglargine234 (118/116) NCT00360334
EXSCEL, 2017exenatideplacebo14752 (7356/7396) Confirmatory NCT01144338
Liutkus, 2010exenatideplacebo165 (111/54)
LEAD 6 (Buse) exe vs lira, 2009exenatide 10µg twice dailyliraglutide 1.8mgNA
H8O-MC-GWBJ, 9698, 10µg/d, 2008exenatide 10µg/dplaceboNA
DeFronzo 10µg/d, 2005exenatide 10µg/dplacebo (add on MET)223 (110/113) Confirmatory NCT00039013
Buse 10µg/d, 2004exenatide 10µg/dplacebo (add on SU)248 (125/123) NCT00039026
Kadowaki (trial 8683), 2009exenatide 10µg/dplacebo (add on SU+/-MET/TZD)151 (111/40) Exploratory
Kendall 10µg/d, 2005exenatide 10µg/dplacebo (add on SU+MET)492 (245/247) Confirmatory NCT00035984
Gill, 2010exenatide 10µg/dplacebo add on MET+/-TZD54 (28/26) Exploratory
Derosa, 2010exenatide 20µgglibenclamide128 (63/65)
Bergenstal (once daily), 2009exenatide 20µg/dBIAsp 30 dailyNA Confirmatory -
Bergenstal (twice daily), 2009exenatide 20µg/dBIAsp 30 twice dailyNA Confirmatory -
Heine, 2005exenatide 20µg/dinsulin (add on SU+MET)549 (282/267)
Barnett, 2007exenatide 20µg/dinsulin (add on SU/MET)263 (136/127) Exploratory NCT00099619
Davis, 2007exenatide 20µg/dinsulin (add on SU/MET)49 (33/16) Confirmatory - NCT00099333
Nauck, 2007exenatide 20µg/dinsulin BIAsp twice daily add on SU+MET501 (253/248) Confirmatory - NCT00082407
Bunck, 2009exenatide 20µg/dinsulin glargine (add on MET)69 (36/33) Exploratory NCT00097500
Apovian, 2010exenatide 20µg/dplacebo194 (96/98)
H8O-MC-GWBJ, 9698, 20µg/d, 2008exenatide 20µg/dplacebo156 (78/78) Confirmatory
Buse, 2011exenatide 20µg/dplacebo (add on insulin)261 (138/123) Confirmatory NCT00765817
DeFronzo 20µg/d, 2005exenatide 20µg/dplacebo (add on MET)NA NCT00039013
Gao, 2009exenatide 20µg/dplacebo (add on MET+/-SU)466 (234/232) Confirmatory NCT00324363
Buse 20µg/d, 2004exenatide 20µg/dplacebo (add on SU)252 (129/123)
Kendall 20µg/d, 2005exenatide 20µg/dplacebo (add on SU+MET)488 (241/247) Confirmatory NCT00035984
Zinman 20µg/j, 2007exenatide 20µg/dplacebo (add on TZD+/-MET)233 (121/112) NCT00099320
Zinman 20µg/j A MODIFIER, 2007exenatide 20µg/dplacebo (add on TZD+/-MET)233 (121/112)
DeFronzo (EXE vs ROSI), 2010exenatide 20µg/drosiglitazone add on MET90 (45/45) Exploratory
DeFronzo, 2008exenatide 20µg/dsitagliptin (add on MET)NA Exploratory NCT00477581
Drucker, 2008exenatide 20µg/dweekly exenatideNA NCT00308139
Exenatide Trial 10749exenatide before lunch and dinnerexenatide before breakfast and dinner377 (187/190) Confirmatory -
phase 2 exenatide once monthlyexenatide once monthlyweekly exenatide121
HEELA (Davies), 2009exenatide other dosesglargineNA
Trial 8078exenatide other dosesinsulin glargine (add on MET/SU)NA
Moretto (DOUBLONS avec druker), 2008exenatide other dosesplacebo233 (155/78) NCT00381342
NCT00085969exenatide other dosesplacebo99 Exploratory NCT00085969
Poon, 2005exenatide other dosesplaceboNA Exploratory NCT00044694
Fineman, 2003exenatide other dosesplacebo (add on MER+/-SU)109 Exploratory
DURATION-3 (Diamant), 2010exenatide weeklyinsulin glargine456 (233/223) Confirmatory - NCT00641056
H8O-MC-GWDE ongoing exenatide weeklyliraglutideNA NCT01029886
DURATION-2 (Bergenstal) (vs pioglitazone), 2010exenatide weeklypioglitazone342 (170/172) NCT00637273
Kim, 2007exenatide weeklyplacebo (add on MET)45 (30/15) Exploratory NCT00103935
DURATION-2 (Bergenstal) (vs sitagliptin), 2010exenatide weeklysitagliptinNA Exploratory NCT00637273



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