Dronedarone antiarrythmic drugs

Multaq

Atrial fibrillation

Maintaining sinus rhythm after cardioversion:  7 trials  - EURIDIS - ADONIS - DAFNE - EURIDIS ADONIS (pooled analysis) - ATHENA - DIONISOS - PALLAS

dronedarone vs amiodarone

No demonstrated result

suggested Adverse events leading to treatment discontinuation by 52% (not demonstrated)

dronedarone vs placebo

No demonstrated result

suggested death or hospitalization for cardiac causes by 15% (not demonstrated)

suggested cardiovascular events by 16% (not demonstrated)

suggested Cardiovascular death by 29% (not demonstrated)

suggested stroke (fatal and non fatal) by 135% (not demonstrated)

suggested Atrial fibrillation recurrence by 29% (not demonstrated)

suggested Cardiac arrhythmic death by 45% (not demonstrated)

suggested hospitalization for AF by 34% (not demonstrated)

suggested Adverse events leading to treatment discontinuation by 55% (not demonstrated)

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Prevention of cardiovascular events:  1 trials  - PALLAS

dronedarone vs placebo

No demonstrated result

suggested death or hospitalization for cardiac causes by 45% (not demonstrated)

suggested cardiovascular events by 128% (not demonstrated)

suggested stroke (fatal and non fatal) by 142% (not demonstrated)

suggested hospitalisation for heart failure by 126% (not demonstrated)

Rate control:  1 trials  - ERATO

dronedarone vs placebo

No demonstrated result

Heart failure

All type of heart failure:  1 trials  - ANDROMEDA

dronedarone vs placebo

No demonstrated result

suggested All cause death by 113% (not demonstrated)