dronedarone vs amiodarone | No demonstrated result suggested Adverse events leading to treatment discontinuation by 52% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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death or hospitalization for cardiac causes | no data | cardiovascular events | no data | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | Atrial fibrillation recurrence | 1.34 [0.92 1.95] | p=1.00 | 0 | 504 | 1 | DIONISOS, | Cardiac nonarrhythmic death | no data | Cardiac arrhythmic death | no data | Vascular noncardiac death | no data | hospitalization for AF | no data | hospitalisation for heart failure | no data | Pro-arrhythmia | no data | All cause death | 0.41 [0.08 2.13] | p=1.00 | 0 | 504 | 1 | DIONISOS, | non cardiovascular death | no data | Adverse events leading to treatment discontinuation | 0.48 [0.24 0.94] | p=0.04 | 0 | 504 | 1 | DIONISOS, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
dronedarone vs placebo | No demonstrated result suggested death or hospitalization for cardiac causes by 15% (not demonstrated) suggested cardiovascular events by 16% (not demonstrated) suggested Cardiovascular death by 29% (not demonstrated) suggested stroke (fatal and non fatal) by 135% (not demonstrated) suggested Atrial fibrillation recurrence by 29% (not demonstrated) suggested Cardiac arrhythmic death by 45% (not demonstrated) suggested hospitalization for AF by 34% (not demonstrated) suggested Adverse events leading to treatment discontinuation by 55% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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death or hospitalization for cardiac causes | 0.85 [0.77 0.94] | p=0.04 | 0 | 9014 | 4 | EURIDIS,ADONIS,ATHENA,PALLAS, | cardiovascular events | 0.84 [0.75 0.95] | p=0.04 | 0 | 7777 | 2 | ATHENA,PALLAS, | Cardiovascular death | 0.71 [0.51 0.98] | p=0.04 | 0 | 4628 | 1 | ATHENA, | myocardial infarction (fatal and non fatal) | 1.00 [0.20 4.95] | p=1.00 | 0 | 3149 | 1 | PALLAS, | stroke (fatal and non fatal) | 2.35 [1.04 5.34] | p=0.04 | 0 | 4386 | 2 | EURIDIS ADONIS (pooled analysis),PALLAS, | Atrial fibrillation recurrence | 0.71 [0.64 0.79] | p=0.04 | 0 | 6064 | 4 | EURIDIS,ADONIS,DAFNE,ATHENA, | Cardiac nonarrhythmic death | 0.96 [0.49 1.86] | p=1.00 | 0 | 4628 | 1 | ATHENA, | Cardiac arrhythmic death | 0.55 [0.34 0.89] | p=0.04 | 0 | 4628 | 1 | ATHENA, | Vascular noncardiac death | 0.84 [0.46 1.53] | p=1.00 | 0 | 4628 | 1 | ATHENA, | hospitalization for AF | 0.66 [0.57 0.77] | p=0.04 | 0 | 4628 | 1 | ATHENA, | hospitalisation for heart failure | 0.99 [0.78 1.26] | p=1.00 | 0 | 7777 | 2 | ATHENA,PALLAS, | Pro-arrhythmia | 0.32 [0.01 16.24] | p=1.00 | 0 | 199 | 1 | DAFNE, | All cause death | 0.92 [0.72 1.17] | p=1.00 | 0 | 9213 | 4 | DAFNE,EURIDIS ADONIS (pooled analysis),ATHENA,PALLAS, | non cardiovascular death | 1.09 [0.74 1.62] | p=1.00 | 0 | 4628 | 1 | ATHENA, | Adverse events leading to treatment discontinuation | 1.55 [1.30 1.85] | p=0.04 | 0 | 6064 | 3 | DAFNE,EURIDIS ADONIS (pooled analysis),ATHENA, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |