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Acebutolol beta-blockers

Neptal - Rhotral - Monitan - Sectral

Acute myocardial infarction

Immediate beta-blockers: 1 trials - Azancot

Acebutolol vs placebo

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
All cause death	0.86 [0.02 46.71]	p=1.00	0	26	1	Azancot,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

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Long term beta-blockers: 1 trials - APSI

Acebutolol vs placebo

No demonstrated result

suggested Cardiovascular death by 59% (not demonstrated)

suggested All cause death by 48% (not demonstrated)

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiac event (fatal and non fatal )	no data
reinfarction	no data
Sudden death	0.69 [0.24 1.97]	p=1.00	0	607	1	APSI,
cardiovascular events	no data
Cardiovascular death	0.41 [0.21 0.83]	p=0.04	0	607	1	APSI,
myocardial infarction (fatal and non fatal)	0.85 [0.35 2.08]	p=1.00	0	607	1	APSI,
cardiac death	no data
All cause death	0.52 [0.28 0.95]	p=0.04	0	607	1	APSI,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

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