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Ardeparin LMWH

Thrombosis prevention

Elective major knee surgery : 1 trials - Levine

ardeparin vs placebo

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
total VTE and all-cause mortality	no data
major or clinically relevant non-major bleeding	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

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General surgery: 1 trials - Godwin

ardeparin vs unfractionated heparin

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
Symptomatic pulmonary embolism	0.52 [0.03 8.33]	p=1.00	0	904	1	Godwin,
asymptomatic DVT	0.07 [0.00 1.44]	p=1.00	0	904	1	Godwin,
Symptomatic venous thromboembolism (DVT, PE)	no data
wound haematoma / infection	no data
transfusion	no data
All cause death	no data
Bleeding	1.38 [0.82 2.33]	p=1.00	0	904	1	Godwin,
Major bleeding	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Orthopedic surgery: 2 trials - Levine - Heit

ardeparin vs placebo

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
total VTE and all-cause mortality	no data
major or clinically relevant non-major bleeding	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

out of hospital Ardeparin vs standard prophylaxis

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
Symptomatic pulmonary embolism	1.45 [0.24 8.73]	p=1.00	0	1195	1	Heit,
Symptomatic deep-vein thrombosis	0.48 [0.15 1.62]	p=1.00	0	1195	1	Heit,
Symptomatic venous thromboembolism (DVT, PE)	0.68 [0.26 1.79]	p=1.00	0	1195	1	Heit,
asymptomatic DVT	no data
distal DVT	no data
proximal DVT	no data
All cause death	0.97 [0.14 6.90]	p=1.00	0	1195	1	Heit,
Minor bleeding	1.58 [0.84 2.97]	p=1.00	0	1161	1	Heit,
Major bleeding	0.65 [0.11 3.89]	p=1.00	0	1161	1	Heit,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

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