semaglutide vs placebo | cardiovascular events by 26% (fully demonstrated) suggested nephropathy by 36% (not demonstrated) suggested retinopathy by 76% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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Amputations | no data | nephropathy | 0.64 [0.46 0.89] | p=0.04 | 0 | 3297 | 1 | SUSTAIN 6, | cardiovascular events | 0.74 [0.58 0.95] | p=0.04 | 0 | 3297 | 1 | SUSTAIN 6, | Cardiovascular death | 0.98 [0.65 1.48] | p=1.00 | 0 | 3297 | 1 | SUSTAIN 6, | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | no data | retinopathy | 1.76 [1.11 2.79] | p=0.04 | 0 | 3297 | 1 | SUSTAIN 6, | microvascular events | no data | hospitalisation for heart failure | no data | All cause death | 1.05 [0.74 1.49] | p=1.00 | 0 | 3297 | 1 | SUSTAIN 6, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |