Alectinib ALK inhibitors

RO5424802 - alectinib - CH5424802

Lung cancer (metastatic)

ALK positive patients:  5 trials  - ALEX - YO29449 - MO29750 - J-ALEX - ALUR

alectinib vs chemotherapy

No demonstrated result

suggested progression or death (progression free survival PFS) by 85% (not demonstrated)

alectinib vs crizotinib

progression or death (progression free survival PFS) by 53% (fully demonstrated)

alectinib vs premetrexed or docetaxel

No demonstrated result