alectinib vs chemotherapy | No demonstrated result suggested progression or death (progression free survival PFS) by 85% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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death (overall survival) | no data | progression or death (progression free survival PFS) | 0.15 [0.08 0.29] | p=0.04 | 0 | -18 | 1 | ALUR, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
alectinib vs crizotinib | progression or death (progression free survival PFS) by 53% (fully demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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death (overall survival) | 0.76 [0.48 1.20] | p=1.00 | 0 | 303 | 1 | ALEX, | progression or death (progression free survival PFS) | 0.47 [0.34 0.65] | p=0.04 | 0 | 303 | 1 | ALEX, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
alectinib vs premetrexed or docetaxel | No demonstrated result | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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death (overall survival) | no data | progression or death (progression free survival PFS) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |