High-dose diuretics vs beta-blockers | No demonstrated result suggested stroke (fatal and non fatal) by 56% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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cardiovascular events | 0.98 [0.78 1.24] | p=1.00 | 0 | 8699 | 1 | MRC (diu vs BB), | Cardiovascular death | no data | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | 0.44 [0.25 0.76] | p=0.04 | 0 | 8699 | 1 | MRC (diu vs BB), | Coronary event | 1.18 [0.91 1.55] | p=1.00 | 0 | 8699 | 1 | MRC (diu vs BB), | Heart failure | no data | All cause death | 1.09 [0.85 1.41] | p=1.00 | 0 | 8699 | 1 | MRC (diu vs BB), | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
High-dose diuretics vs control | No demonstrated result suggested cardiovascular events by 22% (not demonstrated) suggested Cardiovascular death by 19% (not demonstrated) suggested stroke (fatal and non fatal) by 36% (not demonstrated) suggested All cause death by 17% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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cardiovascular events | 0.78 [0.66 0.92] | p=0.04 | 0 | 10940 | 1 | HDFP, | Cardiovascular death | 0.81 [0.67 0.98] | p=0.04 | 0 | 10940 | 1 | HDFP, | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | 0.64 [0.50 0.83] | p=0.04 | 0 | 10940 | 1 | HDFP, | Coronary event | 0.90 [0.73 1.11] | p=1.00 | 0 | 10940 | 1 | HDFP, | Heart failure | no data | All cause death | 0.83 [0.71 0.96] | p=0.04 | 0 | 10940 | 1 | HDFP, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
High-dose diuretics vs placebo | No demonstrated result suggested cardiovascular events by 67% (not demonstrated) suggested Cardiovascular death by 61% (not demonstrated) suggested stroke (fatal and non fatal) by 71% (not demonstrated) suggested Heart failure by 89% (not demonstrated) suggested All cause death by 56% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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cardiovascular events | 0.33 [0.19 0.59] | p=0.04 | 0 | 639 | 3 | VA-I,VA II,Barraclough, | Cardiovascular death | 0.39 [0.18 0.86] | p=0.04 | 0 | 639 | 3 | VA-I,VA II,Barraclough, | myocardial infarction (fatal and non fatal) | no data | stroke (fatal and non fatal) | 0.29 [0.12 0.70] | p=0.04 | 0 | 639 | 3 | VA-I,VA II,Barraclough, | Coronary event | 0.82 [0.46 1.48] | p=1.00 | 0 | 639 | 3 | VA-I,VA II,Barraclough, | Heart failure | 0.11 [0.02 0.60] | p=0.04 | 0 | 639 | 3 | VA-I,VA II,Barraclough, | All cause death | 0.44 [0.21 0.89] | p=0.04 | 0 | 639 | 3 | VA-I,VA II,Barraclough, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |