indapamide trial summary

All type of patient: 3 trials - PATS - HYVET - HYVET pilot

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiovascular events	no data
Cardiovascular death	no data
myocardial infarction (fatal and non fatal)	no data
stroke (fatal and non fatal)	no data
Coronary event	no data
Heart failure	no data
All cause death	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

No demonstrated result

suggested Heart failure by 62% (not demonstrated)

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiovascular events	0.99 [0.86 1.15]	p=1.00	0	9527	2	PATS,HYVET,
Cardiovascular death	0.83 [0.68 1.02]	p=1.00	0	9527	2	PATS,HYVET,
myocardial infarction (fatal and non fatal)	no data
stroke (fatal and non fatal)	0.73 [0.61 0.88]	p=0.04	0	9527	2	PATS,HYVET,
Coronary event	1.03 [0.63 1.67]	p=1.00	0	9527	2	PATS,HYVET,
Heart failure	0.38 [0.23 0.63]	p=0.04	0	3845	1	HYVET,
All cause death	0.87 [0.74 1.01]	p=1.00	0	9527	2	PATS,HYVET,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Elderly (60 years and more): 2 trials - HYVET - HYVET pilot

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiovascular events	no data
Cardiovascular death	no data
myocardial infarction (fatal and non fatal)	no data
stroke (fatal and non fatal)	no data
Coronary event	no data
Heart failure	no data
All cause death	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

No demonstrated result

suggested cardiovascular events by 29% (not demonstrated)

suggested Heart failure by 62% (not demonstrated)

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiovascular events	0.71 [0.56 0.89]	p=0.04	0	3845	1	HYVET,
Cardiovascular death	0.81 [0.62 1.06]	p=1.00	0	3845	1	HYVET,
myocardial infarction (fatal and non fatal)	no data
stroke (fatal and non fatal)	0.73 [0.51 1.06]	p=1.00	0	3845	1	HYVET,
Coronary event	0.74 [0.31 1.76]	p=1.00	0	3845	1	HYVET,
Heart failure	0.38 [0.23 0.63]	p=0.04	0	3845	1	HYVET,
All cause death	0.82 [0.67 1.01]	p=1.00	0	3845	1	HYVET,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Post stroke: 1 trials - PATS

No demonstrated result

suggested cardiovascular events by 27% (not demonstrated)

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiovascular events	1.27 [1.05 1.55]	p=0.04	0	5682	1	PATS,
Cardiovascular death	0.86 [0.64 1.15]	p=1.00	0	5682	1	PATS,
myocardial infarction (fatal and non fatal)	no data
stroke (fatal and non fatal)	0.73 [0.59 0.91]	p=0.04	0	5682	1	PATS,
Coronary event	1.19 [0.66 2.13]	p=1.00	0	5682	1	PATS,
Heart failure	no data
All cause death	0.92 [0.73 1.16]	p=1.00	0	5682	1	PATS,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Uncomplicated hypertension: 1 trials - HAPPY

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiovascular events	0.98 [0.80 1.21]	p=1.00	0	6569	1	HAPPY,
Cardiovascular death	no data
myocardial infarction (fatal and non fatal)	no data
stroke (fatal and non fatal)	1.29 [0.81 2.06]	p=1.00	0	6569	1	HAPPY,
Coronary event	0.89 [0.69 1.14]	p=1.00	0	6569	1	HAPPY,
Heart failure	0.69 [0.40 1.19]	p=1.00	0	6569	1	HAPPY,
All cause death	1.06 [0.80 1.41]	p=1.00	0	6569	1	HAPPY,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Very ederly (80 and more): 2 trials - HYVET - HYVET pilot

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiovascular events	no data
Cardiovascular death	no data
myocardial infarction (fatal and non fatal)	no data
stroke (fatal and non fatal)	no data
Coronary event	no data
Heart failure	no data
All cause death	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

No demonstrated result

suggested cardiovascular events by 29% (not demonstrated)

suggested Heart failure by 62% (not demonstrated)

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiovascular events	0.71 [0.56 0.89]	p=0.04	0	3845	1	HYVET,
Cardiovascular death	0.81 [0.62 1.06]	p=1.00	0	3845	1	HYVET,
myocardial infarction (fatal and non fatal)	no data
stroke (fatal and non fatal)	0.73 [0.51 1.06]	p=1.00	0	3845	1	HYVET,
Coronary event	0.74 [0.31 1.76]	p=1.00	0	3845	1	HYVET,
Heart failure	0.38 [0.23 0.63]	p=0.04	0	3845	1	HYVET,
All cause death	0.82 [0.67 1.01]	p=1.00	0	3845	1	HYVET,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Indapamide diuretics