evolocumab vs placebo (on top statins) | cardiovascular events by 20% (fully demonstrated) suggested myocardial infarction (fatal and non fatal) by 27% (not demonstrated) suggested stroke (fatal and non fatal) by 21% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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death from all causes as adverse event | 0.61 [0.11 3.44] | p=1.00 | 0 | 3072 | 4 | DESCARTES,RUTHERFORD-1,LAPLACE 2,RUTHERFORD-2, | serious adverse events | 1.03 [0.66 1.59] | p=1.00 | 0 | 3072 | 4 | DESCARTES,RUTHERFORD-1,LAPLACE 2,RUTHERFORD-2, | cardiovascular events as adverse event | 1.55 [0.53 4.53] | p=1.00 | 0 | 2905 | 3 | DESCARTES,LAPLACE 2,RUTHERFORD-2, | neurological SAE | no data | Neurocognitive disorder | 0.96 [0.08 11.52] | p=1.00 | 0 | 2004 | 2 | LAPLACE 2,RUTHERFORD-2, | Muscle-related adverse events | 4.95 [0.63 39.21] | p=1.00 | 0 | 329 | 1 | RUTHERFORD-2, | cardiovascular death as adverse event | no data | myocardial infarction as adverse event | no data | unstable angina as adverse death | no data | cardiovascular events | 0.80 [0.73 0.88] | p=0.04 | 0 | 27564 | 1 | FOURIER, | Cardiovascular death | 1.05 [0.88 1.25] | p=1.00 | 0 | 27564 | 1 | FOURIER, | myocardial infarction (fatal and non fatal) | 0.73 [0.65 0.82] | p=0.04 | 0 | 27564 | 1 | FOURIER, | stroke (fatal and non fatal) | 0.79 [0.66 0.95] | p=0.04 | 0 | 27564 | 1 | FOURIER, | Coronary event | no data | Coronary death | no data | Allergic reactions | no data | All cause death | 1.04 [0.91 1.19] | p=1.00 | 0 | 27564 | 1 | FOURIER, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |