Evolocumab PCSK9 Inhibitors

Repatha - AMG-145 - evolocumab - AMG 145

Cardiovascular prevention

All type of patients:  11 trials  - MENDEl 2 - DESCARTES - Mendel 1 - LAPLACE-TIMI 57 - GAUSS 1 - RUTHERFORD-1 - YUKAWA-1 - LAPLACE 2 - GAUSS 2 - RUTHERFORD-2 - FOURIER

evolocumab vs

No demonstrated result

evolocumab vs ezetimibe alone

No demonstrated result

evolocumab vs placebo

No demonstrated result

evolocumab vs placebo (on top statins)

cardiovascular events by 20% (fully demonstrated)

suggested myocardial infarction (fatal and non fatal) by 27% (not demonstrated)

suggested stroke (fatal and non fatal) by 21% (not demonstrated)