Trastuzumab emtansine HER2 inhibitors

Kadcyla - huN901-DM1 - trastuzumab emtansine - T-DM1 cpd - trastuzumab-DM1 conjugate - trastuzumab-DM1 - ado-trastuzumab emtansine

Advanced breast cancer (metastatic)

All type of patients:  2 trials  - EMILIA - TH3RESA

trastuzumab emtansine vs lapatinib plus capecitabine

No demonstrated result

suggested death (overall survival) by 32% (not demonstrated)

suggested progression or death (progression free survival PFS) by 35% (not demonstrated)

trastuzumab emtansine vs usual care

No demonstrated result

suggested progression or death (progression free survival PFS) by 47% (not demonstrated)

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HER2 positive patients:  2 trials  - EMILIA - TH3RESA

trastuzumab emtansine vs lapatinib plus capecitabine

No demonstrated result

suggested death (overall survival) by 32% (not demonstrated)

suggested progression or death (progression free survival PFS) by 35% (not demonstrated)

trastuzumab emtansine vs usual care

No demonstrated result

suggested progression or death (progression free survival PFS) by 47% (not demonstrated)