Milrinone vs placebo | No demonstrated result suggested Sudden death by 57% (not demonstrated) suggested Vertigo by 91% (not demonstrated) suggested myocardial infarction (fatal and non fatal) by 492% (not demonstrated) suggested cardiac death by 33% (not demonstrated) suggested All cause death by 30% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
Sudden death | 1.57 [1.09 2.27] | p=0.04 | 0 | 1088 | 1 | PROMISE, | Worsening heart failure | 1.04 [0.62 1.74] | p=1.00 | 0 | 1318 | 2 | PROMISE,MMTG, | Transplantation | 0.63 [0.10 3.76] | p=1.00 | 0 | 1088 | 1 | PROMISE, | Arrhythmia | 1.28 [0.97 1.71] | p=1.00 | 0 | 1318 | 2 | PROMISE,MMTG, | Vertigo | 1.91 [1.37 2.67] | p=0.04 | 0 | 1318 | 2 | PROMISE,MMTG, | Death from any cause or hospitalization for heart failure | no data | myocardial infarction (fatal and non fatal) | 5.92 [1.05 33.30] | p=0.04 | 0 | 1318 | 2 | PROMISE,MMTG, | cardiac death | 1.33 [1.02 1.74] | p=0.04 | 0 | 1318 | 2 | PROMISE,MMTG, | All cause death | 1.30 [1.00 1.68] | p=0.04 | 0 | 1318 | 2 | PROMISE,MMTG, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |