trial summary

Patient with history of atrial fibrillation: 1 trials - ANTIPAF

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
myocardial infarction (fatal and non fatal)	no data
stroke (fatal and non fatal)	no data
Vascular death	no data
atrial fibrillation recurrence	no data
more than one AF recurrence	no data
Vascular events	no data
hospitalisation for heart failure	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

All type of patients: 2 trials - ROADMAP - ORIENT

No demonstrated result

suggested Cardiovascular death by 312% (not demonstrated)

Endpoint	TE [95% CI]	p val	n	k	trials
macrovascular events	0.88 [0.62 1.24]	p=1.00	4447	1	ROADMAP,
Cardiovascular death	4.12 [1.68 10.11]	p=0.04	5013	2	ROADMAP,ORIENT,
Non fatal MI	0.61 [0.35 1.06]	p=1.00	5013	2	ROADMAP,ORIENT,
All cause death	1.29 [0.82 2.03]	p=1.00	5013	2	ROADMAP,ORIENT,
Non fatal stroke	1.16 [0.61 2.18]	p=1.00	5013	2	ROADMAP,ORIENT,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Patients with or without hypertension: 2 trials - ROADMAP - ORIENT

No demonstrated result

suggested Cardiovascular death by 312% (not demonstrated)

Endpoint	TE [95% CI]	p val	n	k	trials
macrovascular events	0.88 [0.62 1.24]	p=1.00	4447	1	ROADMAP,
Cardiovascular death	4.12 [1.68 10.11]	p=0.04	5013	2	ROADMAP,ORIENT,
Non fatal MI	0.61 [0.35 1.06]	p=1.00	5013	2	ROADMAP,ORIENT,
All cause death	1.29 [0.82 2.03]	p=1.00	5013	2	ROADMAP,ORIENT,
Non fatal stroke	1.16 [0.61 2.18]	p=1.00	5013	2	ROADMAP,ORIENT,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

All type of patients: 1 trials - ORIENT

No demonstrated result

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

All type of patients: 2 trials - ROADMAP - ORIENT

No demonstrated result

suggested Cardiovascular death by 312% (not demonstrated)

Endpoint	TE [95% CI]	p val	n	k	trials
macrovascular events	0.88 [0.62 1.24]	p=1.00	4447	1	ROADMAP,
Cardiovascular death	4.12 [1.68 10.11]	p=0.04	5013	2	ROADMAP,ORIENT,
Non fatal MI	0.61 [0.35 1.06]	p=1.00	5013	2	ROADMAP,ORIENT,
All cause death	1.29 [0.82 2.03]	p=1.00	5013	2	ROADMAP,ORIENT,
Non fatal stroke	1.16 [0.61 2.18]	p=1.00	5013	2	ROADMAP,ORIENT,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients