Flosequinan vs placebo | No demonstrated result suggested Arrhythmia by 236% (not demonstrated) suggested Vertigo by 99% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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Sudden death | 1.23 [0.34 4.50] | p=1.00 | 0 | 650 | 3 | Cowley,FACET,REFLECT, | Worsening heart failure | 0.90 [0.52 1.57] | p=1.00 | 0 | 650 | 3 | Cowley,FACET,REFLECT, | Transplantation | no data | Arrhythmia | 3.36 [1.06 10.65] | p=0.04 | 0 | 515 | 2 | FACET,REFLECT, | Vertigo | 1.99 [1.03 3.84] | p=0.04 | 0 | 515 | 2 | FACET,REFLECT, | Death from any cause or hospitalization for heart failure | no data | myocardial infarction (fatal and non fatal) | 1.61 [0.26 9.87] | p=1.00 | 0 | 193 | 1 | REFLECT, | cardiac death | no data | All cause death | 1.36 [0.71 2.61] | p=1.00 | 0 | 961 | 4 | Cowley,FACET,REFLECT,REFLECT II, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |