trial summary

Pulmonary embolism

All type of patients: 1 trials - Certoparin-Study Group sub group

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
symptomatic venous thromboembolism at the end of treatment	0.35 [0.01 8.87]	p=1.00	0	80	1	Certoparin-Study Group sub group,
recurrent symptomatic venous thromboembolism and death at the end of treatment	no data
Recurrent Symptomatic Venous Thromboembolism or death	no data
fatal pulmonary embolism	no data
All cause death	no data
Minor bleeding	no data
Major bleeding	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Thrombosis prevention

Abdominal surgery: 11 trials - Schmitz-Huebner - Sasahara - Voigt - Welzel - Kakkar - Adolf - Baumgartner - Hoffmann and Largiade - Koppenhagen - Schielke - Koppenhagen

certoparin vs unfractionated heparin

No demonstrated result

Endpoint	TE [95% CI]	p val	n	k	trials
Symptomatic pulmonary embolism	0.30 [0.03 3.19]	p=1.00	771	2	Schielke,Koppenhagen,
asymptomatic DVT	0.88 [0.63 1.22]	p=1.00	2297	9	Schmitz-Huebner,Sasahara,Voigt,Welzel,Kakkar,Adolf,Baumgartner,Koppenhagen,Koppenhagen,
Symptomatic venous thromboembolism (DVT, PE)	0.27 [0.02 3.03]	p=1.00	326	2	Schmitz-Huebner,Voigt,
wound haematoma / infection	2.79 [0.25 30.92]	p=1.00	777	2	Koppenhagen,Koppenhagen,
transfusion	0.98 [0.72 1.33]	p=1.00	879	3	Sasahara,Voigt,Adolf,
All cause death	0.56 [0.26 1.22]	p=1.00	1545	6	Sasahara,Voigt,Baumgartner,Koppenhagen,Schielke,Koppenhagen,
Bleeding	0.83 [0.36 1.93]	p=1.00	379	2	Voigt,Kakkar,
Major bleeding	1.29 [0.65 2.55]	p=1.00	1824	7	Schmitz-Huebner,Voigt,Kakkar,Baumgartner,Hoffmann and Largiade,Koppenhagen,Schielke,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

See more clinical conditions

Elective hip replacement: 2 trials - Haas - Lassen

certoparine + DHE vs Unfractionated heparin

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
total VTE and all-cause mortality	no data
major or clinically relevant non-major bleeding	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

General surgery: 15 trials - Schmitz-Huebner - Sasahara - Voigt - Welzel - Kakkar - Adolf - Heilmann - Baumgartner - Hoffmann and Largiade - Koppenhagen - Schielke - Koppenhagen - Hoffmann and Largiader - Heilmann - Haas

certoparin vs unfractionated heparin

No demonstrated result

suggested Bleeding by 42% (not demonstrated)

Endpoint	TE [95% CI]	p val	n	k	trials
Symptomatic pulmonary embolism	0.97 [0.56 1.68]	p=1.00	24801	5	Schielke,Koppenhagen,Hoffmann and Largiader,Heilmann,Haas,
asymptomatic DVT	0.86 [0.63 1.17]	p=1.00	2921	11	Schmitz-Huebner,Sasahara,Voigt,Welzel,Kakkar,Adolf,Heilmann,Baumgartner,Koppenhagen,Koppenhagen,Heilmann,
Symptomatic venous thromboembolism (DVT, PE)	0.27 [0.02 3.03]	p=1.00	326	2	Schmitz-Huebner,Voigt,
wound haematoma / infection	2.79 [0.25 30.92]	p=1.00	777	2	Koppenhagen,Koppenhagen,
transfusion	0.98 [0.72 1.33]	p=1.00	879	3	Sasahara,Voigt,Adolf,
All cause death	1.07 [0.86 1.32]	p=1.00	24981	8	Sasahara,Voigt,Baumgartner,Koppenhagen,Schielke,Koppenhagen,Heilmann,Haas,
Bleeding	0.58 [0.39 0.87]	p=0.04	737	3	Voigt,Kakkar,Heilmann,
Major bleeding	0.84 [0.58 1.23]	p=1.00	3076	10	Schmitz-Huebner,Voigt,Kakkar,Heilmann,Baumgartner,Hoffmann and Largiade,Koppenhagen,Schielke,Hoffmann and Largiader,Heilmann,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Gynaecological surgery: 2 trials - Heilmann - Heilmann

certoparin vs unfractionated heparin

No demonstrated result

suggested Bleeding by 48% (not demonstrated)

suggested Major bleeding by 42% (not demonstrated)

Endpoint	TE [95% CI]	p val	I2	n	k	trials
Symptomatic pulmonary embolism	1.75 [0.50 6.09]	p=1.00	0	358	1	Heilmann,
asymptomatic DVT	0.78 [0.36 1.73]	p=1.00	0	624	2	Heilmann,Heilmann,
Symptomatic venous thromboembolism (DVT, PE)	no data
wound haematoma / infection	no data
transfusion	no data
All cause death	1.67 [0.39 7.08]	p=1.00	0	358	1	Heilmann,
Bleeding	0.52 [0.33 0.83]	p=0.04	0	358	1	Heilmann,
Major bleeding	0.58 [0.35 0.96]	p=0.04	0	658	2	Heilmann,Heilmann,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Hip Fracture: 1 trials - Lassen

certoparine + DHE vs Unfractionated heparin

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
total VTE and all-cause mortality	no data
major or clinically relevant non-major bleeding	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Medical patients: 1 trials - CERTIFY

certoparin vs UFH

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
Symptomatic deep-vein thrombosis	no data
Symptomatic pulmonary embolism	no data
Deep vein thrombosis	no data
proximal deep-vein thrombosis	no data
Venous thromboembolism or death	no data
asymptomatic DVT	no data
pulmonary embolism (symptomatic and asymptomatic)	no data
fatal pulmonary embolism	no data
Venous thromboembolism	no data
All cause death	no data
Major bleeding	no data
net benefit	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Orthopedic surgery: 3 trials - Haas - Lassen - Lassen

certoparine + DHE vs Unfractionated heparin

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
total VTE and all-cause mortality	no data
major or clinically relevant non-major bleeding	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Patients with immobilization of the lower extremities: 1 trials - Kock

certoparin vs control

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
Venous thromboembolism	0.06 [0.00 1.09]	p=1.00	0	339	1	Kock,
Symptomatic venous thromboembolism (DVT, PE)	0.10 [0.01 1.93]	p=1.00	0	339	1	Kock,
total VTE and all-cause mortality	no data
major or clinically relevant non-major bleeding	no data
Minor bleeding	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients