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Anacetrapib CEPT inhibition

MK-0859 - MK0859 - MK 0859

Cardiovascular prevention

All type of patients: 2 trials - DEFINE - REALIZE

anacetrapib vs placebo

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
Coronary revascularization	no data
Carotid revascularization	no data
cardiovascular events including revascularization	0.83 [0.44 1.58]	p=1.00	0	1928	2	DEFINE,REALIZE,
cardiovascular events	0.76 [0.40 1.47]	p=1.00	0	1623	1	DEFINE,
Cardiovascular death	4.00 [0.45 35.91]	p=1.00	0	1623	1	DEFINE,
stroke (fatal and non fatal)	no data
Coronary event	no data
Coronary death	no data
Non fatal MI	0.67 [0.24 1.88]	p=1.00	0	1623	1	DEFINE,
All cause death	1.38 [0.55 3.44]	p=1.00	0	1623	1	DEFINE,
Non fatal stroke	1.00 [0.29 3.47]	p=1.00	0	1623	1	DEFINE,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

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