ACS (excluding AMI): 2 trials - PLATO - DISPERSE-2 (90mg)
ticagrelor vs clopidogrel | No demonstrated result suggested all cause death, MI, stroke by 16% (not demonstrated) suggested cardiovascular events by 15% (not demonstrated) suggested myocardial infarction (fatal and non fatal) by 16% (not demonstrated) suggested Vascular death by 20% (not demonstrated) suggested All cause death by 21% (not demonstrated) |
All type of patients: 2 trials - PEGASUS 60mg - PEGASUS 90mg
ticagrelor vs placebo (on top aspirin) | No demonstrated result Major bleeding by 126% (harmful effect) suggested cardiovascular events by 15% (not demonstrated) suggested Cardiovascular death by 15% (not demonstrated) suggested myocardial infarction (fatal and non fatal) by 17% (not demonstrated) suggested stroke (fatal and non fatal) by 21% (not demonstrated) suggested Coronary death by 23% (not demonstrated) suggested cardiovascular death, MI, stroke by 15% (not demonstrated) |
All type of patient: 1 trials - EUCLID
ticagrelor vs clopidogrel | No demonstrated result |
All type of patient: 2 trials - PEGASUS 60mg - PEGASUS 90mg
ticagrelor vs placebo (on top aspirin) | No demonstrated result Major bleeding by 126% (harmful effect) suggested cardiovascular events by 15% (not demonstrated) suggested Cardiovascular death by 15% (not demonstrated) suggested myocardial infarction (fatal and non fatal) by 17% (not demonstrated) suggested stroke (fatal and non fatal) by 21% (not demonstrated) suggested Coronary death by 23% (not demonstrated) suggested cardiovascular death, MI, stroke by 15% (not demonstrated) |