Ticagrelor antiplatelets drug

AZD-6140 - AZD6140 - AZD 6140 - Brilinta - Brilique

Acute coronary syndrome

ACS (excluding AMI):  2 trials  - PLATO - DISPERSE-2 (90mg)

ticagrelor vs clopidogrel

No demonstrated result

suggested all cause death, MI, stroke by 16% (not demonstrated)

suggested cardiovascular events by 15% (not demonstrated)

suggested myocardial infarction (fatal and non fatal) by 16% (not demonstrated)

suggested Vascular death by 20% (not demonstrated)

suggested All cause death by 21% (not demonstrated)

See more clinical conditions

All type of patients:  2 trials  - PLATO - DISPERSE-2 (90mg)

ticagrelor vs clopidogrel

No demonstrated result

suggested all cause death, MI, stroke by 16% (not demonstrated)

suggested cardiovascular events by 15% (not demonstrated)

suggested myocardial infarction (fatal and non fatal) by 16% (not demonstrated)

suggested Vascular death by 20% (not demonstrated)

suggested All cause death by 21% (not demonstrated)

Cardiovascular prevention

All type of patients:  2 trials  - PEGASUS 60mg - PEGASUS 90mg

ticagrelor vs placebo (on top aspirin)

No demonstrated result

Major bleeding by 126% (harmful effect)

suggested cardiovascular events by 15% (not demonstrated)

suggested Cardiovascular death by 15% (not demonstrated)

suggested myocardial infarction (fatal and non fatal) by 17% (not demonstrated)

suggested stroke (fatal and non fatal) by 21% (not demonstrated)

suggested Coronary death by 23% (not demonstrated)

suggested cardiovascular death, MI, stroke by 15% (not demonstrated)

See more clinical conditions

Secondary prevention in patients with CAD:  2 trials  - PEGASUS 60mg - PEGASUS 90mg

ticagrelor vs placebo (on top aspirin)

No demonstrated result

Major bleeding by 126% (harmful effect)

suggested cardiovascular events by 15% (not demonstrated)

suggested Cardiovascular death by 15% (not demonstrated)

suggested myocardial infarction (fatal and non fatal) by 17% (not demonstrated)

suggested stroke (fatal and non fatal) by 21% (not demonstrated)

suggested Coronary death by 23% (not demonstrated)

suggested cardiovascular death, MI, stroke by 15% (not demonstrated)

Secondary prevention:  2 trials  - PEGASUS 60mg - PEGASUS 90mg

ticagrelor vs placebo (on top aspirin)

No demonstrated result

Major bleeding by 126% (harmful effect)

suggested cardiovascular events by 15% (not demonstrated)

suggested Cardiovascular death by 15% (not demonstrated)

suggested myocardial infarction (fatal and non fatal) by 17% (not demonstrated)

suggested stroke (fatal and non fatal) by 21% (not demonstrated)

suggested Coronary death by 23% (not demonstrated)

suggested cardiovascular death, MI, stroke by 15% (not demonstrated)

Secondary prevention in patients with intermittent claudication:  1 trials  - EUCLID

ticagrelor vs clopidogrel

No demonstrated result

Coronary artery disease

Peripheral vascular diseases

All type of patient:  1 trials  - EUCLID

ticagrelor vs clopidogrel

No demonstrated result

Post myocardial infarction

All type of patient:  2 trials  - PEGASUS 60mg - PEGASUS 90mg

ticagrelor vs placebo (on top aspirin)

No demonstrated result

Major bleeding by 126% (harmful effect)

suggested cardiovascular events by 15% (not demonstrated)

suggested Cardiovascular death by 15% (not demonstrated)

suggested myocardial infarction (fatal and non fatal) by 17% (not demonstrated)

suggested stroke (fatal and non fatal) by 21% (not demonstrated)

suggested Coronary death by 23% (not demonstrated)

suggested cardiovascular death, MI, stroke by 15% (not demonstrated)