bisoprolol vs placebo | No demonstrated result suggested Death from any cause or hospitalization for any reason by 18% (not demonstrated) suggested Sudden death by 42% (not demonstrated) suggested hospitalisation for heart failure by 34% (not demonstrated) suggested All cause death by 29% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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Death from any cause or hospitalization for any reason | 0.82 [0.71 0.95] | p=0.04 | 0 | 3288 | 2 | CIBIS,CIBIS II, | Sudden death | 0.58 [0.40 0.83] | p=0.04 | 0 | 2647 | 1 | CIBIS II, | NYHA class improvement | 1.42 [0.95 2.14] | p=1.00 | 0 | 641 | 1 | CIBIS, | cardiovascular events | no data | Cardiovascular death | 0.68 [0.44 1.05] | p=1.00 | 0 | 641 | 1 | CIBIS, | Coronary event | no data | Coronary death | no data | hospitalisation for heart failure | 0.66 [0.45 0.97] | p=0.04 | 0 | 641 | 1 | CIBIS, | All cause death | 0.71 [0.58 0.86] | p=0.04 | 0 | 3288 | 2 | CIBIS,CIBIS II, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |