beta carotene vs placebo | No demonstrated result suggested cardiovascular events by 31% (not demonstrated) suggested Cardiovascular death by 28% (not demonstrated) suggested stroke (fatal and non fatal) by 74% (not demonstrated) suggested Coronary event by 80% (not demonstrated) suggested All cause death by 15% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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cardiovascular events | 0.69 [0.62 0.78] | p=0.04 | 0 | 60118 | 3 | PHS beta carotene,WHS beta carotene,WACS beta-caroten, | Cardiovascular death | 0.72 [0.67 0.77] | p=0.04 | 0 | 109186 | 6 | ATBC beta carotene,CARET beta carotene,NSCP (Green) beta carotene,PHS beta carotene,WHS beta carotene,WACS beta-caroten, | stroke (fatal and non fatal) | 0.26 [0.23 0.29] | p=0.04 | 0 | 60118 | 3 | PHS beta carotene,WHS beta carotene,WACS beta-caroten, | ischemic stroke | 1.12 [0.88 1.42] | p=1.00 | 0 | 8171 | 1 | WACS beta-caroten, | Coronary event | 0.20 [0.18 0.23] | p=0.04 | 0 | 60118 | 3 | PHS beta carotene,WHS beta carotene,WACS beta-caroten, | Coronary death | no data | Non fatal MI | 1.09 [0.84 1.41] | p=1.00 | 0 | 8171 | 1 | WACS beta-caroten, | All cause death | 0.85 [0.78 0.92] | p=0.04 | 0 | 81858 | 6 | CARET beta carotene,SCP beta carotene,NSCP (Green) beta carotene,PHS beta carotene,WHS beta carotene,WACS beta-caroten, | Non fatal stroke | 1.10 [0.86 1.41] | p=1.00 | 0 | 8171 | 1 | WACS beta-caroten, | Haemmorhagic stroke | 2.13 [0.92 4.93] | p=1.00 | 0 | 8171 | 1 | WACS beta-caroten, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |