Atrial fibrillation

All type of patients:  13 trials  - A4 (Jais) - Wazni - RESOLVE-AF - MANTRA-PAF - APAF (Pappone) - CAFCOAF (Stabile) - Krittayaphong - ThermoCool AF - Oral - Forleo - Lakkireddy - CABANA - STOP-AF

catheter ablation vs control

No demonstrated result

suggested death or hospitalization for cardiac causes by 17% (not demonstrated)

suggested Atrial fibrillation recurrence by 47% (not demonstrated)

suggested atrial tachyarrhythmia recurrence free survival by 253% (not demonstrated)

suggested Freedom from arrhythmia at 12 months per protocol by 299% (not demonstrated)

suggested freedom from arrhythmia at 12 months - worst case by 275% (not demonstrated)

suggested Freedom from arrhythmia at 12 months - ITT by 155% (not demonstrated)

suggested Symptomatic Atrial Arrhythmia recurrence by 76% (not demonstrated)

suggested Any Atrial Arrhythmia Recurrence by 71% (not demonstrated)

suggested Adverse events by 52% (not demonstrated)

Patients with implantable cardioverter defibrillators

All type of patients:  2 trials  - VTACH - SMASH-VT

catheter ablation before ICD vs no ablation

No demonstrated result

suggested VT or VF by 39% (not demonstrated)

suggested hospitalisation for cardiovascular causes by 45% (not demonstrated)

suggested Appropriate ICD shock by 49% (not demonstrated)

suggested ICD events by 62% (not demonstrated)

Ventricular tachycardia in patients with structural heart disease

All type of patients:  2 trials  - VTACH - SMASH-VT

catheter ablation before ICD vs no ablation

No demonstrated result

suggested VT or VF by 39% (not demonstrated)

suggested hospitalisation for cardiovascular causes by 45% (not demonstrated)

suggested Appropriate ICD shock by 49% (not demonstrated)

suggested ICD events by 62% (not demonstrated)