| torcetrapib vs placebo | No demonstrated result suggested Coronary revascularization by 25% (not demonstrated) suggested All cause death by 53% (not demonstrated) | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
|---|
| Coronary revascularization | 1.25 [1.10 1.41] | p=0.04 | 0 | 16255 | 2 | ILLUMINATE,ILLUSTRATE, | | Carotid revascularization | no data | | cardiovascular events including revascularization | no data | | cardiovascular events | 1.16 [0.95 1.41] | p=1.00 | 0 | 15067 | 1 | ILLUMINATE, | | Cardiovascular death | 1.36 [0.89 2.10] | p=1.00 | 0 | 15971 | 2 | RADIANCE 1,ILLUMINATE, | | stroke (fatal and non fatal) | 0.97 [0.64 1.47] | p=1.00 | 0 | 16255 | 2 | ILLUMINATE,ILLUSTRATE, | | Coronary event | 1.22 [0.98 1.52] | p=1.00 | 0 | 15067 | 1 | ILLUMINATE, | | Coronary death | 1.21 [0.76 1.90] | p=1.00 | 0 | 16255 | 2 | ILLUMINATE,ILLUSTRATE, | | Non fatal MI | 1.17 [0.93 1.48] | p=1.00 | 0 | 17159 | 3 | RADIANCE 1,ILLUMINATE,ILLUSTRATE, | | All cause death | 1.53 [1.12 2.09] | p=0.04 | 0 | 17159 | 3 | RADIANCE 1,ILLUMINATE,ILLUSTRATE, | | Non fatal stroke | 1.01 [0.06 16.18] | p=1.00 | 0 | 904 | 1 | RADIANCE 1, |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
